NDLI: Salidroside induces apoptosis and autophagy in gastric cancer cells via regulation of mitogen-activated protein kinases signaling pathway

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Salidroside induces apoptosis and autophagy in gastric cancer cells via regulation of mitogen-activated protein kinases signaling pathway

Content Provider	Scilit
Author	Huo, Jiege Fang, Zhijun Hu, Canhong Xiang, Shao Li, Lingchang Qin, Feng Xia Wei, Guoli Huang, Xiaofei Ding, Rong
Copyright Year	2021
Abstract	Background: Salidroside, an active ingredient of Rhodiola rosea, exhibits antiproliferative effect in gastric cancer (GC) cells. However, the involvement of salidroside in apoptosis and autophagy of GC cells has not been elucidated. Materials and Methods: Cell viability of BGC-823 cells was assessed by CCK-8 assay, and apoptosis was analyzed with terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling assay and flow cytometry. The apoptosis- and autophagy-associated proteins and mitogen-activated protein kinases (MAPKs) were determined by Western blot analysis. Autophagy was evaluated by green fluorescent protein-fused LC3 punctate formation. Results: Salidroside inhibited proliferation and promoted apoptosis and autophagy of BGC-823 cells in a dose-dependent manner. In addition, salidroside enhanced the phosphorylation of p38 MAPK, ERK1/2, and JNK. Furthermore, inhibition of MAPKs significantly abolished the effects of salidroside in BGC-823 cells. Conclusion: Salidroside induced apoptosis and autophagy of BGC-823 cells via activation of MAPK signaling pathway.
Related Links	http://www.phcog.com/article.asp?issn=0973-1296;year=2021;volume=17;issue=73;spage=179;epage=185;aulast=Hu;type=2
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/pm.pm_119_20
Journal	Pharmacognosy Magazine
Issue Number	73
Volume Number	17
Language	English
Publisher	Medknow
Publisher Date	2021-01-01
Access Restriction	Open
Subject Keyword	Toxicology Apoptosis Autophagy Gastric Cancer Mitogen-activated Protein Kinase Salidroside Pharmacognosy Magazine, Volume 17, Issue 73
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science

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