Heat shock induces neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway

Content Provider	Semantic Scholar
Author	Kano, Yoshio Nakagiri, Sachiko Nohno, Tsutomu Hiragami, Fukumi Furuta, Tomohisa
Copyright Year	2004
Abstract	We investigated the role of the p38 mitogen-activated protein kinase (MAPK) pathway in heat-shock-induced neurite outgrowth of PC12 mutant cells in which nerve growth factor (NGF)-induced neurite outgrowth is impaired. When cultures of the PC12 mutant (PC12m3) cells were exposed to heat stress at 44 degrees C for 10 min, activity of p38 MAPK increased and neurite outgrowth was greatly enhanced. The neurite extension was inhibited by the p38 MAPK inhibitor BS203580. Longer heat treatment of PC12m3 cells provoked cell death, which was enhanced by SB203580. These findings suggest that heat-induced activation of p38 MAPK is responsible for the neurite outgrowth and survival of PC12m3 cells.
Starting Page	302
Ending Page	306
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.brainres.2004.07.053
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899304012181
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899304012181?dgcid=api_sd_search-api-endpoint
PubMed reference number	15488493
Alternate Webpage(s)	https://doi.org/10.1016/j.brainres.2004.07.053
Journal	Medline
Volume Number	1026
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article