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The storage mite Tyrophagus putrescentiae induces greater lung inflammation than house dust mites in mice.
| Content Provider | Europe PMC |
|---|---|
| Author | Kim, Eun-Min Kim, Ju Yeong Kwak, You Shine Yi, Myung-Hee Yong, Tai-Soon |
| Copyright Year | 2024 |
| Abstract | Exposure to storage mite (SM) and house dust mite (HDM) allergens is a risk factor for sensitization and asthma development; however, the related immune responses and their pathology have not been fully investigated. The HDMs Dermatophagoides farinae and Dermatophagoides pteronyssinus and SM Tyrophagus putrescentiae are potent allergens that induce asthma. Most SM-related studies have focused on the allergic reactions of individuals by measuring their immunoglobulin (Ig)E expression. Considering the limited research on this topic, the present study aims to investigate the differences in the immune responses induced by HDMs and SMs and histologically analyze lung tissues in a mouse asthma model to understand the differential effects of HDM and SM. The results revealed that all mite species induced airway inflammation. Mice challenged with T. putrescentiae had the highest airway resistance and total cell, eosinophil, and neutrophil counts in the bronchoalveolar lavage fluid (BALF). The SM-sensitized groups showed more severe lesions and mucus hypersecretions than the HDM-sensitized groups. Although the degree of HDM and SM exposure was the same, the damage to the respiratory lung tissue was more severe in SM-exposed mice, which resulted in excessive mucin secretion and increased fibrosis. Furthermore, these findings suggest that SM sensitization induces a more significant hypersensitivity response in mucosal immunity than HDM sensitization in asthma models. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC11366546&blobtype=pdf |
| ISSN | 29825164 |
| Volume Number | 62 |
| PubMed Central reference number | PMC11366546 |
| Issue Number | 3 |
| PubMed reference number | 39218635 |
| Journal | Parasites, Hosts and Diseases [Parasites Hosts Dis] |
| e-ISSN | 29826799 |
| DOI | 10.3347/phd.24032 |
| Language | English |
| Publisher | The Korean Society for Parasitology and Tropical Medicine |
| Publisher Date | 2024-08-26 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2024 The Korean Society for Parasitology and Tropical Medicine |
| Subject Keyword | Dermatophagoides farinae Dermatophagoides pteronyssinus Tyrophagus putrescentiae house dust mite storage mite asthma lung inflammation mucin 5AC |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology |
