NDLI: NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

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Year: 2022, Volume: 11

Invariant representation of physical stability in the human brain

Conduction velocity along a key white matter tract is associated with autobiographical memory recall ability

Expansion and contraction of resource allocation in sensory bottlenecks

A mechano-osmotic feedback couples cell volume to the rate of cell deformation

Heritability and cross-species comparisons of human cortical functional organization asymmetry

Extrachromosomal circular DNA: Current status and future prospects

Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses

The unmitigated profile of COVID-19 infectiousness

Functional visualization of NK cell-mediated killing of metastatic single tumor cells

Glypican-1 drives unconventional secretion of fibroblast growth factor 2

Proximal CA1 20–40 Hz power dynamics reflect trial-specific information processing supporting nonspatial sequence memory

Putting perception into action with inverse optimal control for continuous psychophysics

Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

Physiological TLR4 regulation in human fetal membranes as an explicative mechanism of a pathological preterm case

Non-rapid eye movement sleep determines resilience to social stress

Partial response electromyography as a marker of action stopping

DNA circles promote yeast ageing in part through stimulating the reorganization of nuclear pore complexes

Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells

Diversity on location

Left hemisphere dominance for bilateral kinematic encoding in the human brain

Estimation and worldwide monitoring of the effective reproductive number of SARS-CoV-2

Multistep loading of a DNA sliding clamp onto DNA by replication factor C

Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

Sparse genetically defined neurons refine the canonical role of periaqueductal gray columnar organization

Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging

Descending neuron population dynamics during odor-evoked and spontaneous limb-dependent behaviors

Wolbachia action in the sperm produces developmentally deferred chromosome segregation defects during the Drosophila mid-blastula transition

Prefrontal-amygdalar oscillations related to social behavior in mice

Quantitative MRI reveals differences in striatal myelin in children with DLD

Early stage NSCLS patients' prognostic prediction with multi-information using transformer and graph neural network model

Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load

Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

Role of anterior insula cortex in context-induced relapse of nicotine-seeking

A dysmorphic mouse model reveals developmental interactions of chondrocranium and dermatocranium

p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation

Correction: Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development

Generation of functional hepatocytes by forward programming with nuclear receptors

Deciphering a hexameric protein complex with Angstrom optical resolution

An intestinally secreted host factor promotes microsporidia invasion of C. elegans

Parallel processing in speech perception with local and global representations of linguistic context

A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers

Locally adaptive temperature response of vegetative growth in Arabidopsis thaliana

Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia

Monkey plays Pac-Man with compositional strategies and hierarchical decision-making

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in C. elegans oocyte meiosis

Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

Influence of sensory modality and control dynamics on human path integration

Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex

Evolving new ways to secure a mate

Unifying the known and unknown microbial coding sequence space

Multiple timescales of sensory-evidence accumulation across the dorsal cortex

Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

Correction: ACE2 pathway regulates thermogenesis and energy metabolism

Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism

Microglia shape the embryonic development of mammalian respiratory networks

Correction: mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking

Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state

Promoting constructive feedback on preprints with the FAST principles

Controllability boosts neural and cognitive signatures of changes-of-mind in uncertain environments

FSH-blocking therapeutic for osteoporosis

Chemogenetics defines a short-chain fatty acid receptor gut–brain axis

Novel insights from a multiomics dissection of the Hayflick limit

Getting the right cells

Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus

The giant staphylococcal protein Embp facilitates colonization of surfaces through Velcro-like attachment to fibrillated fibronectin

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

A biophysical threshold for biofilm formation

The relative binding position of Nck and Grb2 adaptors impacts actin-based motility of Vaccinia virus

A single-cell atlas of the cycling murine ovary

Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria

Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function

Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans

Eviction notice served on Toxoplasma

Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons

Structural basis for cytoplasmic dynein-1 regulation by Lis1

State-dependent activity dynamics of hypothalamic stress effector neurons

Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics

Paraxial mesoderm organoids model development of human somites

Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish

A dynamic clamp protocol to artificially modify cell capacitance

Genetic dissection of the RNA polymerase II transcription cycle

Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite

Rethinking the representation of sound

Correction: NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells

Digital restoration of the pectoral girdles of two Early Cretaceous birds and implications for early-flight evolution

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

Transcriptional regulation of neural stem cell expansion in the adult hippocampus

A meta-analysis of the association between male dimorphism and fitness outcomes in humans

On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members

Serum RNAs can predict lung cancer up to 10 years prior to diagnosis

Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity

Inference of the SARS-CoV-2 generation time using UK household data

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response in breast cancer by regulating the EGF/RAD51 axis

Role of Nrp1 in controlling cortical inter-hemispheric circuits

Early lock-in of structured and specialised information flows during neural development

Decoding the activated stem cell phenotype of the neonatally maturing pituitary

Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos

Hydrodynamic model of fish orientation in a channel flow

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity

Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition

Surveying the experience of postdocs in the United States before and during the COVID-19 pandemic

Tackling variants with antibodies

Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing

Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing

Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms

Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes

Robust cone-mediated signaling persists late into rod photoreceptor degeneration

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

Virtual mouse brain histology from multi-contrast MRI via deep learning

Humans perseverate on punishment avoidance goals in multigoal reinforcement learning

Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

XAB2 dynamics during DNA damage-dependent transcription inhibition

Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice

Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

Peer review without gatekeeping

Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

Investigating the relationship of COVID-19 related stress and media consumption with schizotypy, depression, and anxiety in cross-sectional surveys repeated throughout the pandemic in Germany and the UK

Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification

Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease

Recognition of discrete export signals in early flagellar subunits during bacterial type III secretion

How to assemble a scale-invariant gradient

Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate

Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth

Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity

A squash and a squeeze

When dreams don't come true

Intrinsic excitability mechanisms of neuronal ensemble formation

Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies

Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells

LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration

Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase

How parenthood contributes to gender gaps in academia

Exposing the invader

A novel lineage-tracing mouse model for studying early MmuPV1 infections

Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning

Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors

Towards a unified model of naive T cell dynamics across the lifespan

Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters

Fishing for drugs

Different computations over the same inputs produce selective behavior in algorithmic brain networks

A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech

DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness

A single cell transcriptional roadmap of human pacemaker cell differentiation

Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes

The skeletal muscle circadian clock regulates titin splicing through RBM20

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

Intrinsic mechanical sensitivity of mammalian auditory neurons as a contributor to sound-driven neural activity

The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse

Corticofugal regulation of predictive coding

A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates

Plant SYP12 syntaxins mediate an evolutionarily conserved general immunity to filamentous pathogens

Stereotyped behavioral maturation and rhythmic quiescence in C. elegans embryos

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

Closely related type II-C Cas9 orthologs recognize diverse PAMs

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

Understanding drivers of phylogenetic clustering and terminal branch lengths distribution in epidemics of Mycobacterium tuberculosis

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve

Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair

Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion

Architecture and evolution of the cis-regulatory system of the echinoderm kirrelL gene

KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization

Genomic epidemiology of the first two waves of SARS-CoV-2 in Canada

Under the hood of a moving cell

Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

Mathematical relationships between spinal motoneuron properties

Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound

Identification of electroporation sites in the complex lipid organization of the plasma membrane

Boosting targeted genome editing using the hei-tag

The MIDAS domain of AAA mechanoenzyme Mdn1 forms catch bonds with two different substrates

A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour

Differences in local immune cell landscape between Q fever and atherosclerotic abdominal aortic aneurysms identified by multiplex immunohistochemistry

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal

Bayesian inference of kinetic schemes for ion channels by Kalman filtering

Correction: Drp1 is required for AgRP neuronal activity and feeding

Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells

A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics

Tom70-based transcriptional regulation of mitochondrial biogenesis and aging

Impact of energy limitations on function and resilience in long-wavelength Photosystem II

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

Xbp1 and Brachyury establish an evolutionarily conserved subcircuit of the notochord gene regulatory network

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

Automated systematic evaluation of cryo-EM specimens with SmartScope

Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration

Self-organization of kinetochore-fibers in human mitotic spindles

Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion

Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains

DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells

Phylogenomic analyses of echinoid diversification prompt a re-evaluation of their fossil record

Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells

Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs

Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior

An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination

Poor eyesight reveals a new vision gene

Nuclear hormone receptor NHR-49 acts in parallel with HIF-1 to promote hypoxia adaptation in Caenorhabditis elegans

MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

Control of nuclear size by osmotic forces in Schizosaccharomyces pombe

Using aquatic animals as partners to increase yield and maintain soil nitrogen in the paddy ecosystems

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

Independent and interacting value systems for reward and information in the human brain

Young domestic chicks spontaneously represent the absence of objects

The devil is in the task structure

Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons

What sharks and mammals share

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

A life LINE for large viruses

Ligand-induced shifts in conformational ensembles that describe transcriptional activation

Neuroscout, a unified platform for generalizable and reproducible fMRI research

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

Intravital deep-tumor single-beam 3-photon, 4-photon, and harmonic microscopy

Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

Gene expression phylogenies and ancestral transcriptome reconstruction resolves major transitions in the origins of pregnancy

Fuzzy supertertiary interactions within PSD-95 enable ligand binding

Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

Transmission networks of SARS-CoV-2 in Coastal Kenya during the first two waves: A retrospective genomic study

Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics

Feeling like a 'real' scientist

Lighting up protein design

US women screen at low rates for both cervical and colorectal cancers than a single cancer: a cross-sectional population-based observational study

Cortical microtubule pulling forces contribute to the union of the parental genomes in the Caenorhabditis elegans zygote

Oxytocin neurons mediate the effect of social isolation via the VTA circuits

Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells

Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner

Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

A low-tech, cost-effective and efficient method for safeguarding genetic diversity by direct cryopreservation of poultry embryonic reproductive cells

Admixture of evolutionary rates across a butterfly hybrid zone

PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells

Common coupling map advances GPCR-G protein selectivity

Late-life fitness gains and reproductive death in Cardiocondyla obscurior ants

In situ single particle classification reveals distinct 60S maturation intermediates in cells

Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex

Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases

Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

Meta-research: justifying career disruption in funding applications, a survey of Australian researchers

Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption

Cortical waves mediate the cellular response to electric fields

Waveform detection by deep learning reveals multi-area spindles that are selectively modulated by memory load

Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer

Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis

Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis

Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3

Three-dimensional multi-site random access photostimulation (3D-MAP)

Taste quality and hunger interactions in a feeding sensorimotor circuit

From Gondwana to the Yellow Sea, evolutionary diversifications of true toads Bufo sp. in the Eastern Palearctic and a revisit of species boundaries for Asian lineages

A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer

Minimal requirements for a neuron to coregulate many properties and the implications for ion channel correlations and robustness

Stress diminishes outcome but enhances response representations during instrumental learning

Aging is associated with increased brain iron through cortex-derived hepcidin expression

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells

A native chemical chaperone in the human eye lens

Using positional information to provide context for biological image analysis with MorphoGraphX 2.0

A computational account of why more valuable goals seem to require more effortful actions

AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner

Connecting the lines after a stroke

The TFIIH complex is required to establish and maintain mitotic chromosome structure

Crowding-induced phase separation of nuclear transport receptors in FG nucleoporin assemblies

Intrinsic mechanisms in the gating of resurgent Na+ currents

Distinct architectural requirements for the parS centromeric sequence of the pSM19035 plasmid partition machinery

Early detection of cerebrovascular pathology and protective antiviral immunity by MRI

Balance between breadth and depth in human many-alternative decisions

The ACF chromatin-remodeling complex is essential for Polycomb repression

EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

Complex fitness landscape shapes variation in a hyperpolymorphic species

Ecological and social pressures interfere with homeostatic sleep regulation in the wild

Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children's blood

Microplankton life histories revealed by holographic microscopy and deep learning

Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model

A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

Charting brain growth and aging at high spatial precision

Vaccine-induced COVID-19 mimicry syndrome

Target-specific control of olfactory bulb periglomerular cells by GABAergic and cholinergic basal forebrain inputs

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome

Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows

Pinpointing the tumor-specific T cells via TCR clusters

Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy

Emergence of behaviour in a self-organized living matter network

SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients

Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of resistance to a last-resort antibiotic

A unified view of low complexity regions (LCRs) across species

Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

Shallow neural networks trained to detect collisions recover features of visual loom-selective neurons

Targeted depletion of uterine glandular Foxa2 induces embryonic diapause in mice

Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation

BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking

The role of surface adhesion on the macroscopic wrinkling of biofilms

Development, validation, and application of a machine learning model to estimate salt consumption in 54 countries

Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment

Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets

Neuronal origins of reduced accuracy and biases in economic choices under sequential offers

Authorship then and now

Telomere length regulation by Rif1 protein from Hansenula polymorpha

A Permian fish reveals widespread distribution of neopterygian-like jaw suspension

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits

Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study

Neural effects of continuous theta-burst stimulation in macaque parietal neurons

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

Hybridization alters the shape of the genotypic fitness landscape, increasing access to novel fitness peaks during adaptive radiation

AP-2α and AP-2β cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development

Dendritic branch structure compartmentalizes voltage-dependent calcium influx in cortical layer 2/3 pyramidal cells

Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

Mountain gorillas maintain strong affiliative biases for maternal siblings despite high male reproductive skew and extensive exposure to paternal kin

Gill developmental program in the teleost mandibular arch

Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF

Long-term transverse imaging of the hippocampus with glass microperiscopes

Connectomic analysis of the Drosophila lateral neuron clock cells reveals the synaptic basis of functional pacemaker classes

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study

Dividing communication, at the nanoscale

Putting the theory into 'burstlet theory' with a biophysical model of burstlets and bursts in the respiratory preBötzinger complex

Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice

Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study

Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case–control study

Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

Fat body phospholipid state dictates hunger-driven feeding behavior

An entropic safety catch controls hepatitis C virus entry and antibody resistance

Overwriting the past with supervised plasticity

Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA

Free spermidine evokes superoxide radicals that manifest toxicity

Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon

Correction: Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e

Epithelial-to-mesenchymal transition proceeds through directional destabilization of multidimensional attractor

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

Developing evolution-resistant drugs for COVID-19

Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

Correction: Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

Generation of a CRF1-Cre transgenic rat and the role of central amygdala CRF1 cells in nociception and anxiety-like behavior

Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation

A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes

The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast

Aspirin's effect on kinetic parameters of cells contributes to its role in reducing incidence of advanced colorectal adenomas, shown by a multiscale computational study

Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression

Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence

Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans

A new early branching armored dinosaur from the Lower Jurassic of southwestern China

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation

Experimental evidence that uniformly white sclera enhances the visibility of eye-gaze direction in humans and chimpanzees

Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity

A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules

Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration

Evidence accumulation, not 'self-control', explains dorsolateral prefrontal activation during normative choice

How the brain regulates alcohol intake

Disruption of PIKFYVE causes congenital cataract in human and zebrafish

Automated annotation of birdsong with a neural network that segments spectrograms

A conditional gene-based association framework integrating isoform-level eQTL data reveals new susceptibility genes for schizophrenia

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia

Chronic neurotransmission increases the susceptibility of lateral-line hair cells to ototoxic insults

Structure of the IL-27 quaternary receptor signaling complex

Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression

Environmentally sensitive hotspots in the methylome of the early human embryo

SMAD4 and TGFβ are architects of inverse genetic programs during fate determination of antiviral CTLs

Correction: Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract

Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants

Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

Author-level data confirm the widening gender gap in publishing rates during COVID-19

Connexins evolved after early chordates lost innexin diversity

Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye

Regulation of Nodal signaling propagation by receptor interactions and positive feedback

Laminar microcircuitry of visual cortex producing attention-associated electric fields

Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

Uncovering natural variation in root system architecture and growth dynamics using a robotics-assisted phenomics platform

Environmental response in gene expression and DNA methylation reveals factors influencing the adaptive potential of Arabidopsis lyrata

A novel rhesus macaque model of Huntington's disease recapitulates key neuropathological changes along with motor and cognitive decline

Structural organization and dynamics of FCHo2 docking on membranes

A model-based analysis of the health impacts of COVID-19 disruptions to primary cervical screening by time since last screen for current and future disruptions

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair

STIMulating blood pressure

How collagen becomes 'stiff'

The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress

Machine learning-assisted elucidation of CD81–CD44 interactions in promoting cancer stemness and extracellular vesicle integrity

Personalized computational heart models with T1-mapped fibrotic remodeling predict sudden death risk in patients with hypertrophic cardiomyopathy

Expanding codon size

Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19

Projected resurgence of COVID-19 in the United States in July—December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

Transcription elongation is finely tuned by dozens of regulatory factors

Emergence of a geometric pattern of cell fates from tissue-scale mechanics in the Drosophila eye

Capturing intermediate filament networks

Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions

CASP microdomain formation requires cross cell wall stabilization of domains and non-cell autonomous action of LOTR1

The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice

Ligand binding remodels protein side-chain conformational heterogeneity

Application of ATAC-Seq for genome-wide analysis of the chromatin state at single myofiber resolution

Global organization of neuronal activity only requires unstructured local connectivity

Tropical land use alters functional diversity of soil food webs and leads to monopolization of the detrital energy channel

Genetic integration of behavioural and endocrine components of the stress response

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx

Maintaining naivety of T cells

Retraction: Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

Tissue-specific modifier alleles determine Mertk loss-of-function traits

Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis

The E3 ubiquitin ligase mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation

Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response

Dopaminergic challenge dissociates learning from primary versus secondary sources of information

Airway basal cells show regionally distinct potential to undergo metaplastic differentiation

Satellite glia modulate sympathetic neuron survival, activity, and autonomic function

Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection

Ait1 regulates TORC1 signaling and localization in budding yeast

The orphan ligand, activin C, signals through activin receptor-like kinase 7

Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'

Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

A persistent behavioral state enables sustained predation of humans by mosquitoes

Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock

An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae

Activation of the EGFR/MAPK pathway drives transdifferentiation of quiescent niche cells to stem cells in the Drosophila testis niche

Filamentation modulates allosteric regulation of PRPS

Notch controls the cell cycle to define leader versus follower identities during collective cell migration

A dynamic rhizosphere interplay between tree roots and soil bacteria under drought stress

Ion-ing out the genetic variants of Kir2.1

Correction: The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells

The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function

Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases

Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke

Correction: Structural characterization of NrnC identifies unifying features of dinucleases

Cooperation among c-subunits of FoF1-ATP synthase in rotation-coupled proton translocation

Contingency and selection in mitochondrial genome dynamics

The ellipse of insignificance, a refined fragility index for ascertaining robustness of results in dichotomous outcome trials

A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4

Correction: Adult-born neurons modify excitatory synaptic transmission to existing neurons

Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's

Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors

Structural basis of dynamic P5CS filaments

Conformist social learning leads to self-organised prevention against adverse bias in risky decision making

Hyperreactivity to uncertainty is a key feature of subjective cognitive impairment

Association analyses of host genetics, root-colonizing microbes, and plant phenotypes under different nitrogen conditions in maize

Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase

Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

Cd59 and inflammation regulate Schwann cell development

Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

Visualizing synaptic dopamine efflux with a 2D composite nanofilm

Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment

To biofilm or not to biofilm

NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning

The SPARC complex defines RNAPII promoters in Trypanosoma brucei

RNA-binding proteins direct myogenic cell fate decisions

Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via enhancement of dopamine release

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

A cellular and molecular atlas reveals the basis of chytrid development

Valence biases in reinforcement learning shift across adolescence and modulate subsequent memory

P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells

Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

Estimating the potential to prevent locally acquired HIV infections in a UNAIDS Fast-Track City, Amsterdam

Why do sunflowers have invisible colors?

De novo-designed transmembrane domains tune engineered receptor functions

Molecular determinants of complexin clamping and activation function

A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition

VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

Altered regulation of Ia afferent input during voluntary contraction in humans with spinal cord injury

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation

Distance estimation from monocular cues in an ethological visuomotor task

The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord

Bringing cells to the edge

De novo apical domain formation inside the Drosophila adult midgut epithelium

Competition between parallel sensorimotor learning systems

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis

Highly efficient generation of isogenic pluripotent stem cell models using prime editing

Inferring characteristics of bacterial swimming in biofilm matrix from time-lapse confocal laser scanning microscopy

Mapping circuit dynamics during function and dysfunction

Oligogenic heterozygous inheritance of sperm abnormalities in mouse

Unmasking a two-faced protein

Exploring the conformational diversity of proteins

A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

Humans actively sample evidence to support prior beliefs

Predicting bacterial promoter function and evolution from random sequences

Quantitative mapping of keratin networks in 3D

Motor planning brings human primary somatosensory cortex into action-specific preparatory states

Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies

A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat

Correction: Functional profiling of long intergenic non-coding RNAs in fission yeast

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations

The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

Vinculin recruitment to α-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine

Redoxing PTPN22 activity

Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes

Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3

trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans

Parent-of-origin effects propagate through networks to shape metabolic traits

The geometry of robustness in spiking neural networks

Assessing the effects of stress on feeding behaviors in laboratory mice

Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice

Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification

C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

Multiphoton imaging of neural structure and activity in Drosophila through the intact cuticle

Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome

Juxtacellular opto-tagging of hippocampal CA1 neurons in freely moving mice

The LOTUS initiative for open knowledge management in natural products research

Higher-order olfactory neurons in the lateral horn support odor valence and odor identity coding in Drosophila

Natural-gradient learning for spiking neurons

Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish

Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease

Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection

Life history predicts global population responses to the weather in terrestrial mammals

When your PhD (almost) falls apart

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

Correction: The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

T cells discriminate between groups C1 and C2 HLA-C

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents

Nomograms of human hippocampal volume shifted by polygenic scores

Artificial selection methods from evolutionary computing show promise for directed evolution of microbes

Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming

A visual sense of number emerges from divisive normalization in a simple center-surround convolutional network

Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for intraflagellar transport of radial spokes

Minian, an open-source miniscope analysis pipeline

Octopamine drives honeybee thermogenesis

The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus

Comprehensive machine-learning survival framework develops a consensus model in large-scale multicenter cohorts for pancreatic cancer

Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

Consequences of PDGFRα+ fibroblast reduction in adult murine hearts

Structure of the human ATM kinase and mechanism of Nbs1 binding

Male rat leukocyte population dynamics predict a window for intervention in aging

GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

Genome-wide association study in quinoa reveals selection pattern typical for crops with a short breeding history

Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy

Task-related hemodynamic responses in human early visual cortex are modulated by task difficulty and behavioral performance

Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels

Schema representations in distinct brain networks support narrative memory during encoding and retrieval

Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF–PI3K pathway

Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans

Combining hypothesis- and data-driven neuroscience modeling in FAIR workflows

Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans

BIRC6 modifies risk of invasive bacterial infection in Kenyan children

3D optogenetic control of arteriole diameter in vivo

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

Olfactory responses of Drosophila are encoded in the organization of projection neurons

Correction: Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway

PBN-PVT projections modulate negative affective states in mice

Insights from full-text analyses of the Journal of the American Medical Association and the New England Journal of Medicine

Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34

Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading

Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing

Reverse engineering of metacognition

Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents

Pathway-specific effects of ADSL deficiency on neurodevelopment

Residual force enhancement is affected more by quadriceps muscle length than stretch amplitude

A novel monocyte differentiation pattern in pristane-induced lupus with diffuse alveolar hemorrhage

Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma

Humans optimally anticipate and compensate for an uneven step during walking

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation

Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis

Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays

Mars, a molecule archive suite for reproducible analysis and reporting of single-molecule properties from bioimages

Mechanisms of distributed working memory in a large-scale network of macaque neocortex

Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

Delineating the transcriptional landscape and clonal diversity of virus-specific CD4+ T cells during chronic viral infection

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

Evolutionary conservation of centriole rotational asymmetry in the human centrosome

Teaming up to make kombucha

The Arabidopsis SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the plasma membrane

Group II truncated haemoglobin YjbI prevents reactive oxygen species-induced protein aggregation in Bacillus subtilis

Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography

STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

A novel mechanism of bulk cytoplasmic transport by cortical dynein in Drosophila ovary

Shared mechanisms of auditory and non-auditory vocal learning in the songbird brain

The compliment sandwich

HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling

A frameshift in time

A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

What is next in African neuroscience?

Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing

Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

Enhanced C/EBPβ function promotes hyperplastic versus hypertrophic fat tissue growth and prevents steatosis in response to high-fat diet feeding

Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2

Inhibitory control of frontal metastability sets the temporal signature of cognition

Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice

Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx)

Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians

Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

Visualizing molecules of functional human profilin

Migraine monoclonal antibodies against CGRP change brain activity depending on ligand or receptor target – an fMRI study

Distinct regions of H. pylori's bactofilin CcmA regulate protein–protein interactions to control helical cell shape

RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

Gene age shapes the transcriptional landscape of sexual morphogenesis in mushroom-forming fungi (Agaricomycetes)

Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation

Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling

Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops

Correction: Mapping brain-behavior space relationships along the psychosis spectrum

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability

Evolution of host-microbe cell adherence by receptor domain shuffling

Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

DNA passes through cohesin's hinge as well as its Smc3–kleisin interface

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

Mental health in medical and biomedical doctoral students during the 2020 COVID-19 pandemic and racial protests

Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

Robotic search for optimal cell culture in regenerative medicine

Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

Body mass index and adipose distribution have opposing genetic impacts on human blood traits

Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation

Getting closer to the clinic

Exploring the expression patterns of palmitoylating and de-palmitoylating enzymes in the mouse brain using the curated RNA-seq database BrainPalmSeq

Distinguishing between recruitment and spread of silent chromatin structures in Saccharomyces cerevisiae

Rolling circle RNA synthesis catalyzed by RNA

Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro

More than just an inert dense region

Distinct responses to rare codons in select Drosophila tissues

Reconstitution of surface lipoprotein translocation through the Slam translocon

Interplay of surface interaction and magnetic torque in single-cell motion of magnetotactic bacteria in microfluidic confinement

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

The aging epigenome

Large-scale orientational order in bacterial colonies during inward growth

Impairing one sensory modality enhances another by reconfiguring peptidergic signalling in Caenorhabditis elegans

Rapid, Reference-Free human genotype imputation with denoising autoencoders

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria

Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels

The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress

Squamation and scale morphology at the root of jawed vertebrates

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status

Molecular mechanism of active Cas7-11 in processing CRISPR RNA and interfering target RNA

Information flows from hippocampus to auditory cortex during replay of verbal working memory items

Aberrant causal inference and presence of a compensatory mechanism in autism spectrum disorder

High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

Response to comment on 'SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung'

Nanoscale binding site localization by molecular distance estimation on native cell surfaces using topological image averaging

Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors

Correction: Individual variations in 'Brain Age' relate to early-life factors more than to longitudinal brain change

Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4

Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala

Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure

Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

Variable paralog expression underlies phenotype variation

Perception is associated with the brain's metabolic response to sensory stimulation

Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images

An Archaea-specific c-type cytochrome maturation machinery is crucial for methanogenesis in Methanosarcina acetivorans

Bumblebees retrieve only the ordinal ranking of foraging options when comparing memories obtained in distinct settings

Topoisomerase VI is a chirally-selective, preferential DNA decatenase

Systematic investigation of the link between enzyme catalysis and cold adaptation

Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration

Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming

Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma

A guanosine tetraphosphate (ppGpp) mediated brake on photosynthesis is required for acclimation to nitrogen limitation in Arabidopsis

Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

Open-source, Python-based, hardware and software for controlling behavioural neuroscience experiments

Recovering mixtures of fast-diffusing states from short single-particle trajectories

Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer's disease transgenic mice

DetecDiv, a generalist deep-learning platform for automated cell division tracking and survival analysis

Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity

N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia

Adding a One Health approach to a research framework for minority health and health disparities

The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials

IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer's disease mouse model

Single-cell monitoring of dry mass and dry mass density reveals exocytosis of cellular dry contents in mitosis

Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity

Controlling SARS-CoV-2 in schools using repetitive testing strategies

Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription

Context-dependent relationships between locus coeruleus firing patterns and coordinated neural activity in the anterior cingulate cortex

Alternative splicing of apoptosis genes promotes human T cell survival

Taking on SARS-CoV-2

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

Tradeoff breaking as a model of evolutionary transitions in individuality and limits of the fitness-decoupling metaphor

Lactoferricins impair the cytosolic membrane of Escherichia coli within a few seconds and accumulate inside the cell

Lung evolution in vertebrates and the water-to-land transition

Genetic basis and dual adaptive role of floral pigmentation in sunflowers

Label-free imaging of M1 and M2 macrophage phenotypes in the human dermis in vivo using two-photon excited FLIM

NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes

Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries

Impact of long- and short-range fibre depletion on the cognitive deficits of fronto-temporal dementia

Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments

METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

Gatekeeping astrocyte identity

Speed variations of bacterial replisomes

Machine learning-assisted fluoroscopy of bladder function in awake mice

SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

Protein evidence of unannotated ORFs in Drosophila reveals diversity in the evolution and properties of young proteins

Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism

Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non-primates, but rare in monkey and human

Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection

The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals

Impact of the COVID-19 pandemic on breast cancer screening indicators in a Spanish population-based program: a cohort study

Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain

Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation

SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels

The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

Independent regulation of mitochondrial DNA quantity and quality in Caenorhabditis elegans primordial germ cells

Depletion or cleavage of cohesin during anaphase differentially affects chromatin structure and segregation

Lead-OR: A multimodal platform for deep brain stimulation surgery

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

Humanization of wildlife gut microbiota in urban environments

On the flexibility of the cellular amination network in E coli

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus

Green fluorescent protein-like pigments optimise the internal light environment in symbiotic reef-building corals

Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions

Alternation emerges as a multi-modal strategy for turbulent odor navigation

The extraordinary metabolism of vitamin D

Correction: Humans actively sample evidence to support prior beliefs

Functional characterization of a 'plant-like' HYL1 homolog in the cnidarian Nematostella vectensis indicates a conserved involvement in microRNA biogenesis

Interactions between strains govern the eco-evolutionary dynamics of microbial communities

Most cancers carry a substantial deleterious load due to Hill-Robertson interference

Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3

Correction: Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence

Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina

Focal seizures are organized by feedback between neural activity and ion concentration changes

An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells

CompoundRay, an open-source tool for high-speed and high-fidelity rendering of compound eyes

Cross-modality synthesis of EM time series and live fluorescence imaging

Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

Evolutionary convergence of a neural mechanism in the cavefish lateral line system

Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling

Chemotactic smoothing of collective migration

An empirical energy landscape reveals mechanism of proteasome in polypeptide translocation

CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies

Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock

Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously

The balance of the sexes

A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins

Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms

Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

To breathe or not to breathe?

Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 –tubulin complex

Allosteric modulation of the adenosine A2A receptor by cholesterol

A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease

Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous pre-messenger RNA structure probing

Cohesin-dependence of neuronal gene expression relates to chromatin loop length

PH domain-mediated autoinhibition and oncogenic activation of Akt

Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species

Network design principle for robust oscillatory behaviors with respect to biological noise

Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins

Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

Septin7 is indispensable for proper skeletal muscle architecture and function

Where is that smell coming from?

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection

Foveal vision anticipates defining features of eye movement targets

Macrophage network dynamics depend on haptokinesis for optimal local surveillance

Regional importation and asymmetric within-country spread of SARS-CoV-2 variants of concern in the Netherlands

Nup98-dependent transcriptional memory is established independently of transcription

Mechanism of the cadherin–catenin F-actin catch bond interaction

3D single cell migration driven by temporal correlation between oscillating force dipoles

Correction: Standardized and reproducible measurement of decision-making in mice

Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial

A test of the pioneer factor hypothesis using ectopic liver gene activation

Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

Functional profiling of long intergenic non-coding RNAs in fission yeast

Double NPY motifs at the N-terminus of the yeast t-SNARE Sso2 synergistically bind Sec3 to promote membrane fusion

Microscopic colitis: Etiopathology, diagnosis, and rational management

Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling

In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish

Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice

TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

A neural network model of when to retrieve and encode episodic memories

Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike

It is time for open access in clinical care

Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia

Social-affective features drive human representations of observed actions

Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN

A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

What happens in the brain?

Stability of motor representations after paralysis

Innervation modulates the functional connectivity between pancreatic endocrine cells

Predictors of human-infective RNA virus discovery in the United States, China, and Africa, an ecological study

Automatically tracking feeding behavior in populations of foraging C. elegans

Multi-tract multi-symptom relationships in pediatric concussion

Mammals adjust diel activity across gradients of urbanization

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli

Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity

Disrupted-in-schizophrenia-1 is required for normal pyramidal cell–interneuron communication and assembly dynamics in the prefrontal cortex

Prefrontal cortex supports speech perception in listeners with cochlear implants

Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers

An increase of inhibition drives the developmental decorrelation of neural activity

Nanoscale resolution of microbial fiber degradation in action

A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine

Selenocyanate derived Se-incorporation into the nitrogenase Fe protein cluster

Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses

Evolution of binding preferences among whole-genome duplicated transcription factors

Computational modeling and quantitative physiology reveal central parameters for brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root

Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Experimental evidence that chronic outgroup conflict reduces reproductive success in a cooperatively breeding fish

Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline

Coding of chromatic spatial contrast by macaque V1 neurons

Amygdala-cortical collaboration in reward learning and decision making

Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses

Mutual interaction between visual homeostatic plasticity and sleep in adult humans

Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer's disease continuum

Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis

Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity

Mapping odorant sensitivities reveals a sparse but structured representation of olfactory chemical space by sensory input to the mouse olfactory bulb

Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

Transition to siblinghood causes a substantial and long-lasting increase in urinary cortisol levels in wild bonobos

Genetic loci and metabolic states associated with murine epigenetic aging

Cold protection allows local cryotherapy in a clinical-relevant model of traumatic optic neuropathy

Comparison of freshly cultured versus cryopreserved mesenchymal stem cells in animal models of inflammation: A pre-clinical systematic review

Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4/NF-kB signaling and microglial activation

An image reconstruction framework for characterizing initial visual encoding

Self-assembly of pericentriolar material in interphase cells lacking centrioles

High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast

Little skate genome provides insights into genetic programs essential for limb-based locomotion

Modeling the consequences of the dikaryotic life cycle of mushroom-forming fungi on genomic conflict

Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells

Associating the old with the new

Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson's disease

Most primary olfactory neurons have individually neutral effects on behavior

Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis

Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation

Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice

Implementing robotics and artificial intelligence

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

A new route to the nucleus

Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites

Short-term plasticity in the human visual thalamus

The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation toward the kidney lineage

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

The Neurodata Without Borders ecosystem for neurophysiological data science

The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

Sulforaphane reduces obesity by reversing leptin resistance

Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

Accelerometer-based analyses of animal sleep patterns

Cognitive experience alters cortical involvement in goal-directed navigation

Volume growth in animal cells is cell cycle dependent and shows additive fluctuations

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and Ageing-Related metabolites

Cre/lox regulated conditional rescue and inactivation with zebrafish UFlip alleles generated by CRISPR-Cas9 targeted integration

Fast and slow feedforward inhibitory circuits for cortical odor processing

SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study

Lowland plant arrival in alpine ecosystems facilitates a decrease in soil carbon content under experimental climate warming

Conditional and unconditional components of aversively motivated freezing, flight and darting in mice

Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development

Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking

Reciprocally inhibitory circuits operating with distinct mechanisms are differently robust to perturbation and modulation

Unbiased proteomic and forward genetic screens reveal that mechanosensitive ion channel MSL10 functions at ER–plasma membrane contact sites in Arabidopsis thaliana

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study

Sensing complementary temporal features of odor signals enhances navigation of diverse turbulent plumes

Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

Time encoding migrates from prefrontal cortex to dorsal striatum during learning of a self-timed response duration task

Unique neural coding of crucial versus irrelevant plant odors in a hawkmoth

Coordination of two opposite flagella allows high-speed swimming and active turning of individual zoospores

scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of PirtEGFPf mice in neuropathic pain condition

Three-dimensional structure of kinetochore-fibers in human mitotic spindles

C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

Testosterone pulses paired with a location induce a place preference to the nest of a monogamous mouse under field conditions

Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

A DCL3 dicing code within Pol IV-RDR2 transcripts diversifies the siRNA pool guiding RNA-directed DNA methylation

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model

Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer's disease

The number of cytokinesis nodes in mitotic fission yeast scales with cell size

Environmental selection overturns the decay relationship of soil prokaryotic community over geographic distance across grassland biotas

Neural synchronization is strongest to the spectral flux of slow music and depends on familiarity and beat salience

Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans

Where functional MRI stops, metabolism starts

Prenatal development of neonatal vocalizations

Increased signal-to-noise ratios within experimental field trials by regressing spatially distributed soil properties as principal components

Creation of photocyclic vertebrate rhodopsin by single amino acid substitution

Binary outcomes of enhancer activity underlie stable random monoallelic expression

Colicin E1 opens its hinge to plug TolC

A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

A viral toolbox for conditional and transneuronal gene expression in zebrafish

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

Machine learning sequence prioritization for cell type-specific enhancer design

Muscle systems and motility of early animals highlighted by cnidarians from the basal Cambrian

GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

Structural differences in adolescent brains can predict alcohol misuse

Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome

Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation

The Na+/K+ pump dominates control of glycolysis in hippocampal dentate granule cells

Epigenetic scores for the circulating proteome as tools for disease prediction

Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors

Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads

How the brain processes negative emotions

BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models

Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs

Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals

The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion

Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

Alone, in the dark: The extraordinary neuroethology of the solitary blind mole rat

Novel fast pathogen diagnosis method for severe pneumonia patients in the intensive care unit: randomized clinical trial

The pupillary light response as a physiological index of aphantasia, sensory and phenomenological imagery strength

Parallel processing, hierarchical transformations, and sensorimotor associations along the 'where' pathway

Elevated brain-derived cell-free DNA among patients with first psychotic episode – a proof-of-concept study

Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

Contractile force assessment methods for in vitro skeletal muscle tissues

CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation

A LAMP sequencing approach for high-throughput co-detection of SARS-CoV-2 and influenza virus in human saliva

Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

Increasing stimulus similarity drives nonmonotonic representational change in hippocampus

Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation

Single-molecule analysis of the entire perfringolysin O pore formation pathway

Temporal and thermal profiling of the Toxoplasma proteome implicates parasite Protein Phosphatase 1 in the regulation of Ca2+-responsive pathways

Invariant neural subspaces maintained by feedback modulation

A nucleation barrier spring-loads the CBM signalosome for binary activation

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

Species clustering, climate effects, and introduced species in 5 million city trees across 63 US cities

Semantic relatedness retroactively boosts memory and promotes memory interdependence across episodes

Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice

Accounting for diet and age

Unfolding and identification of membrane proteins in situ

Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance

The big potential of the small frog Eleutherodactylus coqui

Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

The spatiotemporal patterns of major human admixture events during the European Holocene

Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses

Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2

Repeated origins, widespread gene flow, and allelic interactions of target-site herbicide resistance mutations

Stability and asynchrony of local communities but less so diversity increase regional stability of Inner Mongolian grassland

Regional opportunities for tundra conservation in the next 1000 years

Analysis of allelic cross-reactivity of monoclonal IgG antibodies by a multiplexed reverse FluoroSpot assay

Neural defensive circuits underlie helping under threat in humans

Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation

Noisy metabolism can promote microbial cross-feeding

Correction: A dedicated diribonuclease resolves a key bottleneck for the terminal step of RNA degradation

Pneumococcal genetic variability in age-dependent bacterial carriage

iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade

Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

β2-subunit alternative splicing stabilizes Cav2.3 Ca2+ channel activity during continuous midbrain dopamine neuron-like activity

Novel protein markers of androgen activity in humans: proteomic study of plasma from young chemically castrated men

Subcellular proteomics of dopamine neurons in the mouse brain

A specific role for importin-5 and NASP in the import and nuclear hand-off of monomeric H3

A systematic, complexity-reduction approach to dissect the kombucha tea microbiome

Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia

Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

Female fertility and the zona pellucida

Non-canonical function of an Hif-1α splice variant contributes to the sustained flight of locusts

Neural signatures of auditory hypersensitivity following acoustic trauma

Unbiased mosaic variant assessment in sperm: a cohort study to test predictability of transmission

Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types

Slow oscillation–spindle coupling strength predicts real-life gross-motor learning in adolescents and adults

Dithiothreitol causes toxicity in C. elegans by modulating the methionine–homocysteine cycle

Prediction of type 2 diabetes mellitus onset using logistic regression-based scorecards

Core genes can have higher recombination rates than accessory genes within global microbial populations

Neural mechanisms underlying the temporal organization of naturalistic animal behavior

Flexible utilization of spatial- and motor-based codes for the storage of visuo-spatial information

Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial

Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses

Circadian programming of the ellipsoid body sleep homeostat in Drosophila

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

Effect of cancer on outcome of COVID-19 patients: a systematic review and meta-analysis of studies of unvaccinated patients

Correction: Generation of stress fibers through myosin-driven reorganization of the actin cortex

The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression

Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

A generalized cortical activity pattern at internally generated mental context boundaries during unguided narrative recall

Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice

A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

One master to rule them all

MicroRNA-138 controls hippocampal interneuron function and short-term memory in mice

A general decoding strategy explains the relationship between behavior and correlated variability

The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer

Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

In vivo intraoral waterflow quantification reveals hidden mechanisms of suction feeding in fish

Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism

Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice

Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome

Selection for infectivity profiles in slow and fast epidemics, and the rise of SARS-CoV-2 variants

Distinct representations of body and head motion are dynamically encoded by Purkinje cell populations in the macaque cerebellum

Photonic hyperthermia of malignant peripheral nerve sheath tumors at the third near-infrared biowindow

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

Both consumptive and non-consumptive effects of predators impact mosquito populations and have implications for disease transmission

Learning to predict target location with turbulent odor plumes

Particle foraging strategies promote microbial diversity in marine environments

Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells

Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil

Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands

Magnetic stimulation allows focal activation of the mouse cochlea

Full spectrum flow cytometry reveals mesenchymal heterogeneity in first trimester placentae and phenotypic convergence in culture, providing insight into the origins of placental mesenchymal stromal cells

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function

Palatal morphology predicts the paleobiology of early salamanders

m6A modifications regulate intestinal immunity and rotavirus infection

H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans

Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9

A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

Integration of visual and antennal mechanosensory feedback during head stabilization in hawkmoths

Uncertainty-based inference of a common cause for body ownership

Poxviruses capture host genes by LINE-1 retrotransposition

Pupil diameter is not an accurate real-time readout of locus coeruleus activity

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

Primate malarias as a model for cross-species parasite transmission

Experimental evidence that group size generates divergent benefits of cooperative breeding for male and female ostriches

Data-driven, participatory characterization of farmer varieties discloses teff breeding potential under current and future climates

Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters

The role of higher-order thalamus during learning and correct performance in goal-directed behavior

Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial

Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development

Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs

A unifying mechanism governing inter-brain neural relationship during social interactions

Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis

Correction: Niche partitioning facilitates coexistence of closely related honey bee gut bacteria

Rate and oscillatory switching dynamics of a multilayer visual microcircuit model

PRC1 sustains the integrity of neural fate in the absence of PRC2 function

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

The proportion of randomized controlled trials that inform clinical practice

Fitness consequences of outgroup conflict

Opioid analgesia alters corticospinal coupling along the descending pain system in healthy participants

Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain

Rapid transgenerational adaptation in response to intercropping reduces competition

Association of egg consumption, metabolic markers, and risk of cardiovascular diseases: A nested case-control study

The C. elegans gonadal sheath Sh1 cells extend asymmetrically over a differentiating germ cell population in the proliferative zone

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

Metabolic arsenal of giant viruses: Host hijack or self-use?

Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base

Maintaining the joy of discovery

A partially nested cortical hierarchy of neural states underlies event segmentation in the human brain

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker

Process- and product-related impurities in the ChAdOx1 nCov-19 vaccine

Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors

Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2

Telocytes regulate macrophages in periodontal disease

Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity

The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp

µ-Theraphotoxin Pn3a inhibition of CaV3.3 channels reveals a novel isoform-selective drug binding site

Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection

Sequence and structural conservation reveal fingerprint residues in TRP channels

Cavefish cope with environmental hypoxia by developing more erythrocytes and overexpression of hypoxia-inducible genes

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

Brain atlas for glycoprotein hormone receptors at single-transcript level

Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models

Quantifying concordant genetic effects of de novo mutations on multiple disorders

Reconstitution of kinetochore motility and microtubule dynamics reveals a role for a kinesin-8 in establishing end-on attachments

How hungry roots get their microbes

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

Inhibitory proteins block substrate access by occupying the active site cleft of Bacillus subtilis intramembrane protease SpoIVFB

Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes

Risk of heart disease following treatment for breast cancer – results from a population-based cohort study

c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

Flagellar energy costs across the tree of life

A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

External validation of a mobile clinical decision support system for diarrhea etiology prediction in children: A multicenter study in Bangladesh and Mali

Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory

Individualized discovery of rare cancer drivers in global network context

Mapping the functional connectivity of ecosystem services supply across a regional landscape

Generation of vascularized brain organoids to study neurovascular interactions

Long-range migration of centrioles to the apical surface of the olfactory epithelium

Correction: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

Lessons from a catalogue of 6674 brain recordings

DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia

Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves

What triggers inflammation in COVID-19?

Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

The Digital Brain Bank, an open access platform for post-mortem imaging datasets

Bayesian machine learning analysis of single-molecule fluorescence colocalization images

A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag

Quantifying dynamic facial expressions under naturalistic conditions

Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis

Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling

A light-gated transcriptional recorder for detecting cell-cell contacts

Windborne migration amplifies insect-mediated pollination services

An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

Probing the segregation of evoked and spontaneous neurotransmission via photobleaching and recovery of a fluorescent glutamate sensor

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla in mice

Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections

Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

Modular, robust, and extendible multicellular circuit design in yeast

Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition

Archerfish number discrimination

How failure to falsify in high-volume science contributes to the replication crisis

Knowing friend from foe

Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development

Putting interactions on the map

Perceptual restoration fails to recover unconscious processing for smooth eye movements after occipital stroke

Computed tomographic analysis of the dental system of three Jurassic ceratopsians and implications for the evolution of tooth replacement pattern and diet in early-diverging ceratopsians

Fibroblast mechanotransduction network predicts targets for mechano-adaptive infarct therapies

DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

Regeneration of the larval sea star nervous system by wounding induced respecification to the Sox2 lineage

Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses

Circadian oscillations in Trichoderma atroviride and the role of core clock components in secondary metabolism, development, and mycoparasitism against the phytopathogen Botrytis cinerea

Intracellular glycosyl hydrolase PslG shapes bacterial cell fate, signaling, and the biofilm development of Pseudomonas aeruginosa

Illuminating a new path to multicellularity

A scalable and modular automated pipeline for stitching of large electron microscopy datasets

Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami

Adverse childhood experiences and resilience among adult women: A population-based study

Cytosolic aspartate aminotransferase moonlights as a ribosome-binding modulator of Gcn2 activity during oxidative stress

Tongue immune compartment analysis reveals spatial macrophage heterogeneity

High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

Higher-order unimodal olfactory sensory preconditioning in Drosophila

High-resolution mapping demonstrates inhibition of DNA excision repair by transcription factors

Disruption in structural–functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness

Tracking cell lineages in 3D by incremental deep learning

Ecological lipidology

Host-parasite coevolution promotes innovation through deformations in fitness landscapes

Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

Earliest evidence for fruit consumption and potential seed dispersal by birds

Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

Evolution of sexual conflict in scorpionflies

Functional and structural segregation of overlapping helices in HIV-1

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel

Dedicated chaperones coordinate co-translational regulation of ribosomal protein production with ribosome assembly to preserve proteostasis

Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity

Powering the formation of alveoli

Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination

Self-organization of in vitro neuronal assemblies drives to complex network topology

Molecular characteristics and laminar distribution of prefrontal neurons projecting to the mesolimbic system

Drosophila TRPγ is required in neuroendocrine cells for post-ingestive food selection

Clp protease and antisense RNA jointly regulate the global regulator CarD to mediate mycobacterial starvation response

Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria

Integration of mouse ovary morphogenesis with developmental dynamics of the oviduct, ovarian ligaments, and rete ovarii

Dopamine D2Rs coordinate cue-evoked changes in striatal acetylcholine levels

Genomic evidence for global ocean plankton biogeography shaped by large-scale current systems

Competition for fluctuating resources reproduces statistics of species abundance over time across wide-ranging microbiotas

STAG2 promotes the myelination transcriptional program in oligodendrocytes

Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium

Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

A gradual path to mortality

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition

When cells get in the flow

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase

Audiovisual task switching rapidly modulates sound encoding in mouse auditory cortex

Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex

Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

Large protein complex interfaces have evolved to promote cotranslational assembly

Deconstructing cold-induced brown adipocyte neogenesis in mice

Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1

The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes

Microglia orchestrate neuroinflammation

An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37

Genomic landscape of lymphatic malformations: a case series and response to the PI3Kα inhibitor alpelisib in an N-of-1 clinical trial

A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors in Drosophila medulla

Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

Unsupervised learning of haptic material properties

Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease

Growing together gives more rice and aquatic food

Bronchus-associated macrophages efficiently capture and present soluble inhaled antigens and are capable of local Th2 cell activation

Looking for the origins of axons

Contextual control of conditioned pain tolerance and endogenous analgesic systems

A CD4+ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections

Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times

Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient in Drosophila

Functional brain reconfiguration during sustained pain

Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs

Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response

Distinct representation of cue-outcome association by D1 and D2 neurons in the ventral striatum's olfactory tubercle

Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

STAT3-mediated allelic imbalance of novel genetic variant Rs1047643 and B-cell-specific super-enhancer in association with systemic lupus erythematosus

Comment on 'Unexpected plasticity in the life cycle of Trypanosoma brucei'

Stable antibiotic resistance and rapid human adaptation in livestock-associated MRSA

Differentiation signals from glia are fine-tuned to set neuronal numbers during development

Endurance exercise ameliorates phenotypes in Drosophila models of spinocerebellar ataxias

Evolution of multiple omics approaches to define pathophysiology of pediatric acute respiratory distress syndrome

ACE2 pathway regulates thermogenesis and energy metabolism

Neural tracking of phrases in spoken language comprehension is automatic and task-dependent

Judgments of agency are affected by sensory noise without recruiting metacognitive processing

Modular, cascade-like transcriptional program of regeneration in Stentor

A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

Kidney organoids recapitulate human basement membrane assembly in health and disease

Ubiquitination drives COPI priming and Golgi SNARE localization

Keratinocyte PIEZO1 modulates cutaneous mechanosensation

Ear pinnae in a neotropical katydid (Orthoptera: Tettigoniidae) function as ultrasound guides for bat detection

Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy

Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in Drosophila

Self-organized canals enable long-range directed material transport in bacterial communities

P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis

Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis

Traversing missing links in the spread of HIV

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

Drosophila gustatory projections are segregated by taste modality and connectivity

A dual-target herbicidal inhibitor of lysine biosynthesis

The evolution of a counter-defense mechanism in a virus constrains its host range

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution

Different brain systems support learning from received and avoided pain during human pain-avoidance learning

Sampling alternative conformational states of transporters and receptors with AlphaFold2

Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates

Functional requirements for a Samd14-capping protein complex in stress erythropoiesis

Experience-driven rate modulation is reinstated during hippocampal replay

Respiratory alkalosis provokes spike-wave discharges in seizure-prone rats

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

Live imaging of the co-translational recruitment of XBP1 mRNA to the ER and its processing by diffuse, non-polarized IRE1α

An incentive circuit for memory dynamics in the mushroom body of Drosophila melanogaster

Unsupervised Bayesian Ising Approximation for decoding neural activity and other biological dictionaries

The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle

Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain

Enteroendocrine cell types that drive food reward and aversion

Interleukin-33 regulates the endoplasmic reticulum stress of human myometrium via an influx of calcium during initiation of labor

Global analysis of cytosine and adenine DNA modifications across the tree of life

How should COVID-19 vaccines be distributed between the Global North and South: a discrete choice experiment in six European countries

Strategy-dependent effects of working-memory limitations on human perceptual decision-making

Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum

Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products

Leading edge maintenance in migrating cells is an emergent property of branched actin network growth

Novel multicellular prokaryote discovered next to an underground stream

Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells

Measuring the tolerance of the genetic code to altered codon size

Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF

Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types

Multiple ciliary localization signals control INPP5E ciliary targeting

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine

Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion

One-shot generalization in humans revealed through a drawing task

Phosphoproteomics of ATR signaling in mouse testes

Transgenic quails reveal dynamic TCF/β-catenin signaling during avian embryonic development

Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense

A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

Robust and annotation-free analysis of alternative splicing across diverse cell types in mice

The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans

Mixed synapses reconcile violations of the size principle in zebrafish spinal cord

Perceptual coupling and decoupling of the default mode network during mind-wandering and reading

Decomposing the role of alpha oscillations during brain maturation

Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis

Zebrafish airinemes optimize their shape between ballistic and diffusive search

Signature-scoring methods developed for bulk samples are not adequate for cancer single-cell RNA sequencing data

Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways

CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

Spatially bivariate EEG-neurofeedback can manipulate interhemispheric inhibition

OXPHOS deficiencies affect peroxisome proliferation by downregulating genes controlled by the SNF1 signaling pathway

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

How I learned to redefine academic success as a senior postdoc

WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae

Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

Correction: A two-lane mechanism for selective biological ammonium transport

Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

All eyes on attention

Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa

Nucleoporin107 mediates female sexual differentiation via Dsx

HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury

The biology of C. richardii as a tool to understand plant evolution

Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

Cells use molecular working memory to navigate in changing chemoattractant fields

Comment on 'SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung'

Cortical adaptation to sound reverberation

Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography

Human visual gamma for color stimuli

Cell-type-specific responses to associative learning in the primary motor cortex

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction

Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

Data-driven causal analysis of observational biological time series

Nuclear fascin regulates cancer cell survival

The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates

A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats

Botulinum neurotoxin accurately separates tonic vs. phasic transmission and reveals heterosynaptic plasticity rules in Drosophila

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1+ cells via ciliary TGF-β signaling

Drosulfakinin signaling modulates female sexual receptivity in Drosophila

COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron)

Patient-specific Boolean models of signalling networks guide personalised treatments

State-dependent representations of mixtures by the olfactory bulb

Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells

Time-resolved parameterization of aperiodic and periodic brain activity

Why both sides of the gender equation matter

Correction: Highly contiguous assemblies of 101 drosophilid genomes

Fast, high-throughput production of improved rabies viral vectors for specific, efficient and versatile transsynaptic retrograde labeling

Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation

Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex

Low and high frequency intracranial neural signals match in the human associative cortex

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

Agl24 is an ancient archaeal homolog of the eukaryotic N-glycan chitobiose synthesis enzymes

Correction: Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism

Surviving on low-energy light comes at a price

Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination

Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

EZ Clear for simple, rapid, and robust mouse whole organ clearing

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

Convergent mosaic brain evolution is associated with the evolution of novel electrosensory systems in teleost fishes

Global analysis of cell behavior and protein dynamics reveals region-specific roles for Shroom3 and N-cadherin during neural tube closure

Cancer type classification using plasma cell-free RNAs derived from human and microbes

The rhesus macaque as a success story of the Anthropocene

An auxin-inducible, GAL4-compatible, gene expression system for Drosophila

Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior

Ecdysone coordinates plastic growth with robust pattern in the developing wing

Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis

Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior

Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells

Proposing a neural framework for the evolution of elaborate courtship displays

Motor cortex activity across movement speeds is predicted by network-level strategies for generating muscle activity

Flexible and efficient simulation-based inference for models of decision-making

Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes

Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones

Trends in female-selective abortion among Asian diasporas in the United States, United Kingdom, Canada and Australia

Associative learning drives longitudinally graded presynaptic plasticity of neurotransmitter release along axonal compartments

Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery

Human muscle spindles are wired to function as controllable signal-processing devices

Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study

Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition

Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses

Arbidol inhibits human esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Host ecology regulates interspecies recombination in bacteria of the genus Campylobacter

History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure

A global view of the aspiring physician-scientist

Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization

The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells

Both prey and predator features predict the individual predation risk and survival of schooling prey

The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis

Touch-sensitive stamens enhance pollen dispersal by scaring away visitors

Impact of blindness onset on the representation of sound categories in occipital and temporal cortices

A novel and accurate full-length HTT mouse model for Huntington's disease

A new role for Hif-1α

Effects of side-effect risk framing strategies on COVID-19 vaccine intentions: a randomized controlled trial

Ribonucleotide reductase, a novel drug target for gonorrhea

Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy

Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study

Oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

Towards a molecular mechanism underlying mitochondrial protein import through the TOM and TIM23 complexes

Understanding implicit sensorimotor adaptation as a process of proprioceptive re-alignment

Innexin function dictates the spatial relationship between distal somatic cells in the Caenorhabditis elegans gonad without impacting the germline stem cell pool

Identification of putative enhancer-like elements predicts regulatory networks active in planarian adult stem cells

Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development

An auto-inhibited state of protein kinase G and implications for selective activation

Spatial transcriptomic and single-nucleus analysis reveals heterogeneity in a gigantic single-celled syncytium

Cannabidiol activates neuronal Kv7 channels

Proton-transporting heliorhodopsins from marine giant viruses

Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

Ca2+ inactivation of the mammalian ryanodine receptor type 1 in a lipidic environment revealed by cryo-EM

An estimate of the deepest branches of the tree of life from ancient vertically evolving genes

Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5

Correction: Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation

Androglobin, a chimeric mammalian globin, is required for male fertility

The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein

Suppression weakens unwanted memories via a sustained reduction of neural reactivation

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity

Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNP

The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

Correction: Humans perseverate on punishment avoidance goals in multigoal reinforcement learning

The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

Hematopoietic plasticity mapped in Drosophila and other insects

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context

How splicing confers treatment resistance in prostate cancer

Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration

Contribution of behavioural variability to representational drift

TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling

PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors

Exogenous capture accounts for fundamental differences between pro- and antisaccade performance

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

Eco-evolutionary dynamics modulate plant responses to global change depending on plant diversity and species identity

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

The Jurassic rise of squamates as supported by lepidosaur disparity and evolutionary rates

Learning accurate path integration in ring attractor models of the head direction system

Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

The remarkable gymnastics of ORC

Excitatory and inhibitory D-serine binding to the NMDA receptor

Plexins promote Hedgehog signaling through their cytoplasmic GAP activity

Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs

Induction of osteogenesis by bone-targeted Notch activation

Flexible use of memory by food-caching birds

Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel

Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse

Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation

Characterization of full-length CNBP expanded alleles in myotonic dystrophy type 2 patients by Cas9-mediated enrichment and nanopore sequencing

Developmental stage-specific spontaneous activity contributes to callosal axon projections

Stimulus dependence of directed information exchange between cortical layers in macaque V1

UP-DOWN states and ripples differentially modulate membrane potential dynamics across DG, CA3, and CA1 in awake mice

KLC4 shapes axon arbors during development and mediates adult behavior

Heterogeneity of the GFP fitness landscape and data-driven protein design

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

Multi-omics investigation of Clostridioides difficile-colonized patients reveals pathogen and commensal correlates of C. difficile pathogenesis

A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes

Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

DunedinPACE, a DNA methylation biomarker of the pace of aging

SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity

Learning cortical representations through perturbed and adversarial dreaming

Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells

Enhancing and inhibitory motifs regulate CD4 activity

Alternate patterns of temperature variation bring about very different disease outcomes at different mean temperatures

A novel gene ZNF862 causes hereditary gingival fibromatosis

GENESPACE tracks regions of interest and gene copy number variation across multiple genomes

Broca's cerebral asymmetry reflects gestural communication's lateralisation in monkeys (Papio anubis)

Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair

Perception of an object's global shape is best described by a model of skeletal structure in human infants

A vibrissa pathway that activates the limbic system

Global chromatin mobility induced by a DSB is dictated by chromosomal conformation and defines the HR outcome

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding

Welcome to the lab

Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo

SWI/SNF senses carbon starvation with a pH-sensitive low-complexity sequence

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

Visceral organ morphogenesis via calcium-patterned muscle constrictions

Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1

CaV2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury

Post-acute sequelae of COVID-19: A metabolic perspective

Sex differences and sex bias in human circadian and sleep physiology research

Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

Tumor elimination by clustered microRNAs miR-306 and miR-79 via noncanonical activation of JNK signaling

Frequency-specific neural signatures of perceptual content and perceptual stability

Highlighting the positive aspects of being a PhD student

A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions

Locked in a pro-inflammatory state

The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

Why I shrank my lab by half

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges

Isometric spiracular scaling in scarab beetles—implications for diffusive and advective oxygen transport

Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

Mutational robustness changes during long-term adaptation in laboratory budding yeast populations

RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro

Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

Risk factors relate to the variability of health outcomes as well as the mean: A GAMLSS tutorial

Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells

Dynamic allostery in substrate binding by human thymidylate synthase

Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

Endocytic trafficking promotes vacuolar enlargements for fast cell expansion rates in plants

Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins

Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

A neural mechanism for detecting object motion during self-motion

Resurrecting essential amino acid biosynthesis in mammalian cells

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

Correction: The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp

Structural basis for the absence of low-energy chlorophylls in a photosystem I trimer from Gloeobacter violaceus

Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

Glycan processing in the Golgi as optimal information coding that constrains cisternal number and enzyme specificity

Age and diet shape the genetic architecture of body weight in diversity outbred mice

Radiocarbon and genomic evidence for the survival of Equus Sussemionus until the late Holocene

Species-specific chromatin landscape determines how transposable elements shape genome evolution

Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury

Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum

Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

Fast bacterial growth reduces antibiotic accumulation and efficacy

Pervasive translation in Mycobacterium tuberculosis

How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition

Glutamine metabolism modulates chondrocyte inflammatory response

Widespread nociceptive maps in the human neonatal somatosensory cortex

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

Selfee, self-supervised features extraction of animal behaviors

Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel

Frequency- and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

Regulation of presynaptic Ca2+ channel abundance at active zones through a balance of delivery and turnover

Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning

Shining a light on hematopoietic stem cells

Microsaccades as a marker not a cause for attention-related modulation

The control and training of single motor units in isometric tasks are constrained by a common input signal

Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy

Sigma oscillations protect or reinstate motor memory depending on their temporal coordination with slow waves

Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development

Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells

Ontogeny of circulating lipid metabolism in pregnancy and early childhood – a longitudinal population study

Determination of oligomeric states of proteins via dual-color colocalization with single molecule localization microscopy

Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

Condensation of Ede1 promotes the initiation of endocytosis

Having an abortion during your PhD

Combining transgenesis with paratransgenesis to fight malaria

A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis

Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution

Spontaneous neuronal oscillations in the human insula are hierarchically organized traveling waves

VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors

Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

Developmental changes in story-evoked responses in the neocortex and hippocampus

Constructing the hierarchy of predictive auditory sequences in the marmoset brain

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NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

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NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Noah Gregory Shuart Luis Sojo Shaoyi Sun Karen Nelkenbrecher Matthew Taron Matthew Waldbrook Diana Weeratunge Steven Wesolowski Aaron Williams Michael Wilson Zhiwei Xie Rhena Yoo JP Johnson Thilo Focken Kuldip Khakh Parisa Karimi Tari Celine Dube Samuel J. Goodchild Jean-Christophe Andrez Girish Bankar David Bogucki Kristen Burford Elaine Chang Sultan Chowdhury Richard Dean Gina de Boer Shannon Decker Christoph Dehnhardt Mandy Feng Wei Gong Michael Grimwood Abid Hasan Angela Hussainkhel Qi Jia Stephanie Lee Jenny Li Sophia Lin Andrea Lindgren Verner Lofstrand Janette Mezeyova Rostam Namdari Clint Young Alla Zenova Wei Zhang Alison J. Cutts Robin P. Sherrington Simon N. Pimstone Raymond Winquist Charles J. Cohen James R. Empfield
Abstract	NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (GoF) mutations lead to excess NaV1.6 sodium current, or other indications where NaV1.6 mediated hyper-excitability contributes to disease (Gardella and Møller, 2019; Johannesen et al., 2019; Veeramah et al., 2012). NBI-921352 is a potent inhibitor of NaV1.6 (IC500.051 µM), with exquisite selectivity over other sodium channel isoforms (selectivity ratios of 756 X for NaV1.1, 134 X for NaV1.2, 276 X for NaV1.7, and >583 Xfor NaV1.3, NaV1.4, and NaV1.5). NBI-921352is a state-dependent inhibitor, preferentially inhibiting inactivatedchannels. The state dependence leads to potent stabilization of inactivation, inhibiting NaV1.6 currents, including resurgent and persistent NaV1.6 currents, while sparing the closed/rested channels. The isoform-selective profile of NBI-921352 led to a robust inhibition of action-potential firing in glutamatergic excitatory pyramidal neurons, while sparing fast-spiking inhibitory interneurons, where NaV1.1 predominates. Oral administration of NBI-921352 prevented electrically induced seizures in a Scn8a GoF mouse,as well as in wild-type mouse and ratseizure models. NBI-921352 was effective in preventing seizures at lower brain and plasma concentrations than commonly prescribed sodium channel inhibitor anti-seizure medicines (ASMs) carbamazepine, phenytoin, and lacosamide. NBI-921352 waswell tolerated at higher multiples of the effective plasma and brain concentrations than those ASMs. NBI-921352 is entering phase II proof-of-concept trials for the treatment of SCN8A-developmental epileptic encephalopathy (SCN8A-DEE) and adult focal-onset seizures.
e-ISSN	2050084X
DOI	10.7554/eLife.72468
Journal	eLife
Volume Number	11
Language	English
Publisher	eLife Sciences Publications Ltd
Publisher Date	2022-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Medicine Science Biology (general) Epilepsy Scn8a Nbi-921352 Anti-seizure Medicine
Content Type	Text
Resource Type	Article

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