NDLI: Assessment of antibiotic treatment on Anopheles darlingi survival and susceptibility to Plasmodium vivax

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Najara Akira Costa dos Santos Felipe Neves Magi Alice Oliveira Andrade Alessandra da Silva Bastos Soraya dos Santos Pereira Jansen Fernandes Medeiros Maisa da Silva Araujo
Abstract	Antibiotic treatment has been used to enhance anopheline susceptibility to Plasmodium infection, because bacterial microbiota play a fundamental role in modulating the vector competence of mosquitoes that transmit Plasmodium parasites. However, few studies have examined the impact of antibiotic treatments on Plasmodium vivax sporogonic development in neotropical anopheline mosquitoes. Herein, we assessed the impact of antibiotic treatment on P. vivax development and survival in Anopheles darlingi, the main vector of malaria in the Amazon region. Female mosquitoes were treated continuously with antibiotics to impact the gut bacterial load and then tested for prevalence, infection intensity, and survival in comparison with untreated mosquitoes. Antibiotic-fed mosquitoes had not dramatic impact on P. vivax development previously observed in P. falciparum. However, antibiotic treatment increases mosquito survival, which is known to increase vectorial capacity. These findings raise questions about the effect of antibiotics on P. vivax development and survival in An. darlingi.
e-ISSN	1664302X
DOI	10.3389/fmicb.2022.971083
Journal	Frontiers in Microbiology
Volume Number	13
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2022-10-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Microbiology Microbiota Plasmodium Vivax Anopheles Darlingi Antibiotic Artificial Infection Vectorial Capacity
Content Type	Text
Resource Type	Article

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