NDLI: Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease

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Year: 2022, Volume: 11

Year: 2022, Volume: 10

Year: 2021, Volume: 10

A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide

Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

Network dynamics underlying OFF responses in the auditory cortex

tRNA sequences can assemble into a replicator

Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy

An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation

Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations

Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events

A new Heterodontosaurus specimen elucidates the unique ventilatory macroevolution of ornithischian dinosaurs

Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

Development and characterization of a chronic implant mouse model for vagus nerve stimulation

Correction: Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees

Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

Multisensory-motor integration in olfactory navigation of silkmoth, Bombyx mori, using virtual reality system

The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

Sushi domain-containing protein 4 controls synaptic plasticity and motor learning

A move in response to starvation

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

Deciding when to exit

A covariation analysis reveals elements of selectivity in quorum sensing systems

Ciliary chemosensitivity is enhanced by cilium geometry and motility

Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids

Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression

SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis

Genomic basis for drought resistance in European beech forests threatened by climate change

Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules

NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase

Asking questions of psychedelic microdosing

Expression of a CO2-permeable aquaporin enhances mesophyll conductance in the C4 species Setaria viridis

Temporo-cerebellar connectivity underlies timing constraints in audition

Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

Metabolomic profiling reveals a differential role for hippocampal glutathione reductase in infantile memory formation

DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels

Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish

Introduction to the EQIPD quality system

Genetic variation, environment and demography intersect to shape Arabidopsis defense metabolite variation across Europe

Aggregation in the spotlight

Standardized and reproducible measurement of decision-making in mice

Specialized neurons in the right habenula mediate response to aversive olfactory cues

Slowing the body slows down time perception

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

The temporary cost of dominance

Cardiolipin targets a dynamin-related protein to the nuclear membrane

A multifaceted analysis reveals two distinct phases of chloroplast biogenesis during de-etiolation in Arabidopsis

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

Distinct neural networks for the volitional control of vocal and manual actions in the monkey homologue of Broca's area

Aversive stimuli bias corticothalamic responses to motivationally significant cues

Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline

The many states of STIM1

Distinct synaptic transfer functions in same-type photoreceptors

Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

Wings and halteres act as coupled dual oscillators in flies

The evolution of division of labour in structured and unstructured groups

Stronger net selection on males across animals

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

A coupled mechano-biochemical model for cell polarity guided anisotropic root growth

Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics

Quantifying the impact of quarantine duration on COVID-19 transmission

DNA damage—how and why we age?

Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study

Combinatorial deployment of F-actin regulators to build complex 3D actin structures in vivo

Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8

Skipping ahead: A circuit for representing the past, present, and future

Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)

The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

To choose or not to choose

GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals

APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

A Brownian ratchet model for DNA loop extrusion by the cohesin complex

Cystic proliferation of germline stem cells is necessary to reproductive success and normal mating behavior in medaka

Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

Establishment of H3K9me3-dependent heterochromatin during embryogenesis in Drosophila miranda

A new model of decision processing in instrumental learning tasks

Finger somatotopy is preserved after tetraplegia but deteriorates over time

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

What's the use?

Where ketamine and dopamine collide

Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

Charge-driven condensation of RNA and proteins suggests broad role of phase separation in cytoplasmic environments

Attention network modulation via tRNS correlates with attention gain

Preparing for implantation

Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria

Swarming bacteria undergo localized dynamic phase transition to form stress-induced biofilms

Sub-minute prediction of brain temperature based on sleep–wake state in the mouse

Sex and self defense

LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells

Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

An open-source device for measuring food intake and operant behavior in rodent home-cages

Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements

Author-sourced capture of pathway knowledge in computable form using Biofactoid

Evidence for a deep, distributed and dynamic code for animacy in human ventral anterior temporal cortex

L-DOPA modulates activity in the vmPFC, nucleus accumbens, and VTA during threat extinction learning in humans

Long-term stability of cortical ensembles

Gut bacterial aggregates as living gels

Optimal evolutionary decision-making to store immune memory

Conserved visual capacity of rats under red light

LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

Impact of COVID-19-related disruptions to measles, meningococcal A, and yellow fever vaccination in 10 countries

Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors

A digital 3D reference atlas reveals cellular growth patterns shaping the Arabidopsis ovule

The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum

The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics

Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice

A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis

A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

Visualizing formation of the active site in the mitochondrial ribosome

Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny

Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases

Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections

Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways

Dinosaur bonebed amber from an original swamp forest soil

The allosteric modulation of complement C5 by knob domain peptides

CTP and parS coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning

Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

EKLF/KLF1 expression defines a unique macrophage subset during mouse erythropoiesis

Repeated outbreaks drive the evolution of bacteriophage communication

A CTP-dependent gating mechanism enables ParB spreading on DNA

Synchronous activity patterns in the dentate gyrus during immobility

Design principles of the ESCRT-III Vps24-Vps2 module

Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations

Differential conditioning produces merged long-term memory in Drosophila

Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation

What have we learned?

Relationship between changing malaria burden and low birth weight in sub-Saharan Africa: A difference-in-differences study via a pair-of-pairs approach

A polarity pathway for exocyst-dependent intracellular tube extension

Songbirds can learn flexible contextual control over syllable sequencing

Synaptic memory requires CaMKII

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

Visually induced changes in cytokine production in the chick choroid

Losing out to improve group fitness

Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos

Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease

Scanned optogenetic control of mammalian somatosensory input to map input-specific behavioral outputs

Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels

Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

A unified platform to manage, share, and archive morphological and functional data in insect neuroscience

Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism

Lapses in perceptual decisions reflect exploration

MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface

Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA

Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

A monster of a disease

Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

Rolling controls sperm navigation in response to the dynamic rheological properties of the environment

Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

A pentameric protein ring with novel architecture is required for herpesviral packaging

Fast and flexible estimation of effective migration surfaces

Type VI secretion system killing by commensal Neisseria is influenced by expression of type four pili

The loopy world of cohesin

Predicting cancer risk based on family history

ZAF, the first open source fully automated feeder for aquatic facilities

Experimental evidence for delayed post-conflict management behaviour in wild dwarf mongooses

Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

Correction: Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

PRMT5 regulates ovarian follicle development by facilitating Wt1 translation

Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset

Sensing the world and its dangers: An evolutionary perspective in neuroimmunology

Structure-guided microbial targeting of antistaphylococcal prodrugs

C. elegans does a spit take

Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

Daily electrical activity in the master circadian clock of a diurnal mammal

Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2

Distinct skeletal stem cell types orchestrate long bone skeletogenesis

Single-cell transcriptome analysis identifies a unique tumor cell type producing multiple hormones in ectopic ACTH and CRH secreting pheochromocytoma

A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies

Cortical excitability signatures for the degree of sleepiness in human

Persistent effects of pair bonding in lung cancer cell growth in monogamous Peromyscus californicus

Ancient DNA reveals the lost domestication history of South American camelids in Northern Chile and across the Andes

The secret life of memory receptors

Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

Characterizing the hum of hovering animals

DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Visualizing anatomically registered data with brainrender

Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae

Social selectivity and social motivation in voles

Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

A new player in the dermis

Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN

Correction: Deep evolutionary origin of gamete-directed zygote activation by KNOX/BELL transcription factors in green plants

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

Parallel processing by distinct classes of principal neurons in the olfactory cortex

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood–brain barrier formation and maturation

Structural insights into the activation of human calcium-sensing receptor

A functional model of adult dentate gyrus neurogenesis

An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection

Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease

Gated recurrence enables simple and accurate sequence prediction in stochastic, changing, and structured environments

Cortico-subcortical β burst dynamics underlying movement cancellation in humans

The genomic consequences of hybridization

Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila

Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

Coherent theta activity in the medial and orbital frontal cortices encodes reward value

Spatial modulation of visual responses arises in cortex with active navigation

Genetically engineered mice for combinatorial cardiovascular optobiology

Sex difference analyses under scrutiny

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

Understanding neural signals of post-decisional performance monitoring: An integrative review

Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner

A deep learning algorithm to translate and classify cardiac electrophysiology

Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

Gamete expression of TALE class HD genes activates the diploid sporophyte program in Marchantia polymorpha

The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication

AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa

Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

Nutrient dominance governs the assembly of microbial communities in mixed nutrient environments

A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery

Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition

Improving preclinical studies through replications

HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2

A sex-specific evolutionary interaction between ADCY9 and CETP

The induction of pyrenoid synthesis by hyperoxia and its implications for the natural diversity of photosynthetic responses in Chlamydomonas

A genetic intervention

NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development

Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

Perinatal granulopoiesis and risk of pediatric asthma

Multiple decisions about one object involve parallel sensory acquisition but time-multiplexed evidence incorporation

Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel

Association of human breast cancer CD44-/CD24- cells with delayed distant metastasis

Repeated introductions and intensive community transmission fueled a mumps virus outbreak in Washington State

Functional independence of endogenous μ- and δ-opioid receptors co-expressed in cholinergic interneurons

Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans

The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

Psychosocial experiences modulate asthma-associated genes through gene-environment interactions

Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

Utility of polygenic embryo screening for disease depends on the selection strategy

Two different cell-cycle processes determine the timing of cell division in Escherichia coli

Correction: Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines

Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

Stress resets ancestral heritable small RNA responses

Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons

Cytokine ranking via mutual information algorithm correlates cytokine profiles with presenting disease severity in patients infected with SARS-CoV-2

High-speed, three-dimensional imaging reveals chemotactic behaviour specific to human-infective Leishmania parasites

eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

The solubility product extends the buffering concept to heterotypic biomolecular condensates

Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1

Cohesin architecture and clustering in vivo

Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans

March Mammal Madness and the power of narrative in science outreach

How the insect central complex could coordinate multimodal navigation

Functional reallocation of sensory processing resources caused by long-term neural adaptation to altered optics

Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species

Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia

Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

Combinations of maternal-specific repressive epigenetic marks in the endosperm control seed dormancy

Development and validation of a nomogram to better predict hypertension based on a 10-year retrospective cohort study in China

Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans

Olig3 regulates early cerebellar development

New fossils of Australopithecus sediba reveal a nearly complete lower back

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

Conserved sperm factors are no longer a bone of contention

Coupling between motor cortex and striatum increases during sleep over long-term skill learning

Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

Learning developmental mode dynamics from single-cell trajectories

Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

Identical sequences found in distant genomes reveal frequent horizontal transfer across the bacterial domain

In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish

Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

Glucose restriction drives spatial reorganization of mevalonate metabolism

STING mediates immune responses in the closest living relatives of animals

Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing

The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging

A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

Visual pursuit behavior in mice maintains the pursued prey on the retinal region with least optic flow

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer

Evolution of diversity in metabolic strategies

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

The right time for senescence

Decoding subjective emotional arousal from EEG during an immersive virtual reality experience

Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain

Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

Alpha oscillations and event-related potentials reflect distinct dynamics of attribute construction and evidence accumulation in dietary decision making

Short and long sleeping mutants reveal links between sleep and macroautophagy

No fire without smoke (particles)

Three-dimensional reconstruction of a whole insect reveals its phloem sap-sucking mechanism at nano-resolution

Learning differentially shapes prefrontal and hippocampal activity during classical conditioning

Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS–Hook–FHIP complexes

Putting organelles in their place

Alcohol consumption in the general population is associated with structural changes in multiple organ systems

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

A divalent boost from magnesium

eIF2B conformation and assembly state regulate the integrated stress response

Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

Distinct neural mechanisms underlie subjective and objective recollection and guide memory-based decision making

Fine-tuned repression of Drp1-driven mitochondrial fission primes a 'stem/progenitor-like state' to support neoplastic transformation

Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy

CLAMP and Zelda function together to promote Drosophila zygotic genome activation

Predicting changes in osmolality

Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

Linking functional and molecular mechanisms of host resilience to malaria infection

Improving oligo-conjugated antibody signal in multimodal single-cell analysis

How cells determine the number of polarity sites

Retraction: Alcohol drinking alters stress response to predator odor via BNST kappa opioid receptor signaling in male mice

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

Fast deep neural correspondence for tracking and identifying neurons in C. elegans using semi-synthetic training

Functional biology in its natural context: A search for emergent simplicity

Humans use forward thinking to exploit social controllability

Neurogenomic insights into the behavioral and vocal development of the zebra finch

Introgression shapes fruit color convergence in invasive Galápagos tomato

Transsynaptic mapping of Drosophila mushroom body output neurons

Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools

Neural correlates of ingroup bias for prosociality in rats

Binocular rivalry reveals an out-of-equilibrium neural dynamics suited for decision-making

Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

Effect of SARS-CoV-2 proteins on vascular permeability

Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development

Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

Patterns of within-host genetic diversity in SARS-CoV-2

Delilah, prospero, and D-Pax2 constitute a gene regulatory network essential for the development of functional proprioceptors

CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway

Risk of motor vehicle collisions after methadone use

Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

aCPSF1 cooperates with terminator U-tract to dictate archaeal transcription termination efficacy

Single caudate neurons encode temporally discounted value for formulating motivation for action

Consensus-based guidance for conducting and reporting multi-analyst studies

Preventing collateral damage

scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial

External signals regulate continuous transcriptional states in hematopoietic stem cells

Multi-syndrome, multi-gene risk modeling for individuals with a family history of cancer with the novel R package PanelPRO

Structure and analysis of nanobody binding to the human ASIC1a ion channel

Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

Acquisition of innate odor preference depends on spontaneous and experiential activities during critical period

A transcriptomic taxonomy of Drosophila circadian neurons around the clock

Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

Constructing an adult orofacial premotor atlas in Allen mouse CCF

From mice to men

An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

Endoglycan plays a role in axon guidance by modulating cell adhesion

Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion

Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

Separable pupillary signatures of perception and action during perceptual multistability

Punishment insensitivity in humans is due to failures in instrumental contingency learning

Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

Mechanically transduced immunosorbent assay to measure protein-protein interactions

Endomembrane targeting of human OAS1 p46 augments antiviral activity

A rapid whisker-based decision underlying skilled locomotion in mice

Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA

Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain

Graphical-model framework for automated annotation of cell identities in dense cellular images

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

insomniac links the development and function of a sleep-regulatory circuit

High-resolution imaging of skin deformation shows that afferents from human fingertips signal slip onset

HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration

fruitless tunes functional flexibility of courtship circuitry during development

Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD

A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

Muscle-specific economy of force generation and efficiency of work production during human running

Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction

TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

The long and short of it

The clonal structure and dynamics of the human T cell response to an organic chemical hapten

Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease

Scaled, high fidelity electrophysiological, morphological, and transcriptomic cell characterization

Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

Spatio-temporal associations between deforestation and malaria incidence in Lao PDR

Cross-reactive antibodies after SARS-CoV-2 infection and vaccination

Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells

Quantitative mapping of human hair greying and reversal in relation to life stress

Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses

Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age

Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics

Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator

The global burden of yellow fever

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

Metal microdrive and head cap system for silicon probe recovery in freely moving rodent

A bacterial membrane sculpting protein with BAR domain-like activity

Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase

All-trans retinoic acid induces synaptic plasticity in human cortical neurons

Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

The generation of cortical novelty responses through inhibitory plasticity

Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae

CEM500K, a large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning

Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Membrane binding controls ordered self-assembly of animal septins

Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells

Monitoring single-cell dynamics of entry into quiescence during an unperturbed life cycle

Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion

The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila

Causal neural mechanisms of context-based object recognition

In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases

Cis-regulatory variants affect gene expression dynamics in yeast

Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis

Structural determinants of voltage-gating properties in calcium channels

Proximity proteomics in a marine diatom reveals a putative cell surface-to-chloroplast iron trafficking pathway

Presynaptic inhibition of dopamine neurons controls optimistic bias

Resonating neurons stabilize heterogeneous grid-cell networks

Phylogenomic and mitogenomic data can accelerate inventorying of tropical beetles during the current biodiversity crisis

Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives

Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity

Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis

Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

Quantifying the relationship between genetic diversity and population size suggests natural selection cannot explain Lewontin's Paradox

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection

MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

Distinguishing different modes of growth using single-cell data

Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self–nonself discrimination

Racial inequity in grant funding from the US National Institutes of Health

Deep evolutionary origin of gamete-directed zygote activation by KNOX/BELL transcription factors in green plants

Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons

Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

Structurally distributed surface sites tune allosteric regulation

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

The gut microbiota is a transmissible determinant of skeletal maturation

ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression

The kinase PDK1 is critical for promoting T follicular helper cell differentiation

A zebrafish embryo screen utilizing gastrulation identifies the HTR2C inhibitor pizotifen as a suppressor of EMT-mediated metastasis

HIF1α is required for NK cell metabolic adaptation during virus infection

YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway

Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

Dynamic dichotomy of accumbal population activity underlies cocaine sensitization

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

Physical observables to determine the nature of membrane-less cellular sub-compartments

Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins

Micron-scale geometrical features of microtubules as regulators of microtubule organization

Loss of heterozygosity results in rapid but variable genome homogenization across yeast genetic backgrounds

Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling

Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

Development and genetics of red coloration in the zebrafish relative Danio albolineatus

Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease

A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria

A prion accelerates proliferation at the expense of lifespan

Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model

Naïve individuals promote collective exploration in homing pigeons

Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex

5'-UTR SNP of FGF13 causes translational defect and intellectual disability

Correction: Distinct neuronal populations contribute to trace conditioning and extinction learning in the hippocampal CA1

The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion

Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

Single molecule microscopy reveals key physical features of repair foci in living cells

Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

Stimulus-dependent relationships between behavioral choice and sensory neural responses

Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis

Neural mechanisms of modulations of empathy and altruism by beliefs of others' pain

Learning precise spatiotemporal sequences via biophysically realistic learning rules in a modular, spiking network

Cost-precision trade-off relation determines the optimal morphogen gradient for accurate biological pattern formation

Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart

Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

Calcium signaling through a transient receptor channel is important for Toxoplasma gondii growth

Generation of stress fibers through myosin-driven reorganization of the actin cortex

Trading mental effort for confidence in the metacognitive control of value-based decision-making

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain

Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

Tachykinin signaling inhibits task-specific behavioral responsiveness in honeybee workers

The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

Weak evidence of country- and institution-related status bias in the peer review of abstracts

Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish

Topography and motion of acid-sensing ion channel intracellular domains

PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes

The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

Superior colliculus drives stimulus-evoked directionally biased saccades and attempted head movements in head-fixed mice

Co-circulation of multiple influenza A reassortants in swine harboring genes from seasonal human and swine influenza viruses

A new, 'hip' way to breathe

Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

Nano-scale architecture of blood-brain barrier tight-junctions

Specialized contributions of mid-tier stages of dorsal and ventral pathways to stereoscopic processing in macaque

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors

Rapid genome editing by CRISPR-Cas9-POLD3 fusion

Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers

MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

Linking spatial self-organization to community assembly and biodiversity

Finding the right sequence of drugs

Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

Live imaging reveals the cellular events downstream of SARM1 activation

IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

Corollary discharge promotes a sustained motor state in a neural circuit for navigation

Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity

A state space modeling approach to real-time phase estimation

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study

Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression

Correction: A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development

DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels

Diverse viral proteases activate the NLRP1 inflammasome

Information flow, cell types and stereotypy in a full olfactory connectome

Processing of motion boundary orientation in macaque V2

Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines

Mapping the fly's 'brain in the brain'

A novel live-cell imaging assay reveals regulation of endosome maturation

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

Neural network of social interaction observation in marmosets

You can keep your coat on

CA1 pyramidal cell diversity is rooted in the time of neurogenesis

ReporterSeq reveals genome-wide dynamic modulators of the heat shock response across diverse stressors

Distributed functions of prefrontal and parietal cortices during sequential categorical decisions

Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex

A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function

KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction

Effects of domestication on the gut microbiota parallel those of human industrialization

Miro1-dependent mitochondrial dynamics in parvalbumin interneurons

Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels

Whole-genome sequencing analysis of semi-supercentenarians

Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

T cell stiffness is enhanced upon formation of immunological synapse

Vaccination induces rapid protection against bacterial pneumonia via training alveolar macrophage in mice

Single-cell RNA sequencing of the Strongylocentrotus purpuratus larva reveals the blueprint of major cell types and nervous system of a non-chordate deuterostome

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

Why sex matters

5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function

Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo

Lessons from an initiative to address gender bias

IGF-1 facilitates extinction of conditioned fear

Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network

Limited inhibition of multiple nodes in a driver network blocks metastasis

Add mass spectrometry to the pandemic toolbox

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

Combined effect of cell geometry and polarity domains determines the orientation of unequal division

Visualizing traumatic brain injuries

Selfing is the safest sex for Caenorhabditis tropicalis

Properdin oligomers adopt rigid extended conformations supporting function

Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer's disease

Correction: GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients

The essential role of Dnmt1 in gametogenesis in the large milkweed bug Oncopeltus fasciatus

HIF1α stabilization in hypoxia is not oxidant-initiated

Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

Regional sequencing collaboration reveals persistence of the T12 Vibrio cholerae O1 lineage in West Africa

Continuous attractors for dynamic memories

Protomer alignment modulates specificity of RNA substrate recognition by Ire1

Beware the algorithm

The cis-regulatory effects of modern human-specific variants

Mapping the future for coral reefs

Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

Neural encoding of actual and imagined touch within human posterior parietal cortex

Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

Rapid adaptation of endocytosis, exocytosis, and eisosomes after an acute increase in membrane tension in yeast cells

Insula to mPFC reciprocal connectivity differentially underlies novel taste neophobic response and learning in mice

Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons

Artistoo, a library to build, share, and explore simulations of cells and tissues in the web browser

Exploring a new way to think about climate regions

When a virus lies in wait

Secondary metabolites of Hülle cells mediate protection of fungal reproductive and overwintering structures against fungivorous animals

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

Structural basis of Stu2 recruitment to yeast kinetochores

The whale shark genome reveals patterns of vertebrate gene family evolution

IFN-γ mediates Paneth cell death via suppression of mTOR

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

Regulation of human mTOR complexes by DEPTOR

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

The structural connectome constrains fast brain dynamics

BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB

Reversal of the adipostat control of torpor during migration in hummingbirds

RNA splicing programs define tissue compartments and cell types at single-cell resolution

Widespread variation in heat tolerance and symbiont load are associated with growth tradeoffs in the coral Acropora hyacinthus in Palau

Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair

A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors

Symmetry breaking meets multisite modification

Pore mutation N617D in the skeletal muscle DHPR blocks Ca2+ influx due to atypical high-affinity Ca2+ binding

A remote sensing derived data set of 100 million individual tree crowns for the National Ecological Observatory Network

Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats

Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

Identification of functionally distinct macrophage subpopulations in Drosophila

Efficacy profile of the CYD-TDV dengue vaccine revealed by Bayesian survival analysis of individual-level phase III data

Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires

A community-led initiative for training in reproducible research

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

Sequence features of retrotransposons allow for epigenetic variability

Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry

Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

Inversion of pheromone preference optimizes foraging in C. elegans

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

Infection-exposure in infancy is associated with reduced allergy-related disease in later childhood in a Ugandan cohort

Bayesian inference of population prevalence

Analysis of the mechanosensor channel functionality of TACAN

Quantitative control of noise in mammalian gene expression by dynamic histone regulation

AKAP79 enables calcineurin to directly suppress protein kinase A activity

Emergence and propagation of epistasis in metabolic networks

Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala

Human embryo polarization requires PLC signaling to mediate trophectoderm specification

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

The role of oxytocin in delay of gratification and flexibility in non-social decision making

Like a clock in the rabbit's visual cortex

Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity

CDK control pathways integrate cell size and ploidy information to control cell division

Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes

Distributed coding of duration in rodent prefrontal cortex during time reproduction

Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network

DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila

NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis

Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme

Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

A major new dimension in the problem of brain injury

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

Microglial trogocytosis and the complement system regulate axonal pruning in vivo

Future life expectancy in Europe taking into account the impact of smoking, obesity, and alcohol

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization

Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry

Reproducible analysis of disease space via principal components using the novel R package syndRomics

Developmental hourglass and heterochronic shifts in fin and limb development

An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution

Temporo-parietal cortex involved in modeling one's own and others' attention

4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

Failure to progress

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

Receptor repertoires of murine follicular T helper cells reveal a high clonal overlap in separate lymph nodes in autoimmunity

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis

Do wealth and inequality associate with health in a small-scale subsistence society?

Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

A cell atlas of the chick retina based on single-cell transcriptomics

Mechanism of life-long maintenance of neuron identity despite molecular fluctuations

Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants

Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer's disease

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

The structure of behavioral variation within a genotype

SARS-CoV-2 shedding dynamics across the respiratory tract, sex, and disease severity for adult and pediatric COVID-19

Correction: Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

Membrane-partitioned cell wall synthesis in mycobacteria

Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

Wild cereal grain consumption among Early Holocene foragers of the Balkans predates the arrival of agriculture

Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility

Light sets the brain's daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk

tTARGIT AAVs mediate the sensitive and flexible manipulation of intersectional neuronal populations in mice

Archaeal chromatin 'slinkies' are inherently dynamic complexes with deflected DNA wrapping pathways

Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

A neural circuit for flexible control of persistent behavioral states

Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain

The social life of cyanobacteria

'Fearful-place' coding in the amygdala-hippocampal network

Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

Calcium dependence of neurotransmitter release at a high fidelity synapse

The rise and fall of the ancient northern pike master sex-determining gene

Correction: Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development

Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia

Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair

The amyloid precursor protein is a conserved Wnt receptor

Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

What happens when forests fall?

Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories

Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

Biosynthesis of a sulfated exopolysaccharide, synechan, and bloom formation in the model cyanobacterium Synechocystis sp. strain PCC 6803

Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex

Mechanisms underlying microglial colonization of developing neural retina in zebrafish

Correction: Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

Addressing shortfalls of laboratory HbA1c using a model that incorporates red cell lifespan

Globally defining the effects of mutations in a picornavirus capsid

Reverting the mode of action of the mitochondrial FOF1-ATPase by Legionella pneumophila preserves its replication niche

Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells

Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior

A matter of nerves

Creating and controlling visual environments using BonVision

Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material

A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

A two-stage solution

Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

Matrix-trapped viruses can prevent invasion of bacterial biofilms by colonizing cells

Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

Individual history of winning and hierarchy landscape influence stress susceptibility in mice

Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity

Restored TDCA and valine levels imitate the effects of bariatric surgery

Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface

Creating SPACE to evolve academic assessment

Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

Drosophila STING protein has a role in lipid metabolism

Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction

Correction: Structural basis for plant plasma membrane protein dynamics and organization into functional nanodomains

Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

Optimal plasticity for memory maintenance during ongoing synaptic change

Characterization of the ABC methionine transporter from Neisseria meningitidis reveals that lipidated MetQ is required for interaction

Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

Universal and taxon-specific trends in protein sequences as a function of age

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

Motor memories of object dynamics are categorically organized

Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor

Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses

Quantitative mapping of dense microtubule arrays in mammalian neurons

Tracking the movement of discrete gating charges in a voltage-gated potassium channel

Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

Interneuron-specific gamma synchronization indexes cue uncertainty and prediction errors in lateral prefrontal and anterior cingulate cortex

Perinatal development of innate immune topology

Evolutionary dynamics of transposable elements in bdelloid rotifers

Data mining methodology for response to hypertension symptomology—application to COVID-19-related pharmacovigilance

Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

Random access parallel microscopy

Spherical arena reveals optokinetic response tuning to stimulus location, size, and frequency across entire visual field of larval zebrafish

Thalamus and claustrum control parallel layer 1 circuits in retrosplenial cortex

Neural representation of abstract task structure during generalization

High potency of sequential therapy with only β-lactam antibiotics

α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

In situ cryo-ET structure of phycobilisome–photosystem II supercomplex from red alga

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

An actin-related protein that is most highly expressed in Drosophila testes is critical for embryonic development

Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

Working together

Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice

Interpreting wide-band neural activity using convolutional neural networks

A mobile genetic element increases bacterial host fitness by manipulating development

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

Rotational dynamics in motor cortex are consistent with a feedback controller

An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites

Single-cell growth inference of Corynebacterium glutamicum reveals asymptotically linear growth

Short-chain fatty acids activate acetyltransferase p300

Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity

Spike frequency adaptation supports network computations on temporally dispersed information

Allosteric conformational ensembles have unlimited capacity for integrating information

An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth

Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe

Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

Molecular architecture of the human tRNA ligase complex

Bidirectional regulation of glial potassium buffering – glioprotection versus neuroprotection

Correction: Wireless recording from unrestrained monkeys reveals motor goal encoding beyond immediate reach in frontoparietal cortex

Lying in a 3T MRI scanner induces neglect-like spatial attention bias

Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America

Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

Channel nuclear pore complex subunits are required for transposon silencing in Drosophila

Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

A novel bivalent chromatin associates with rapid induction of camalexin biosynthesis genes in response to a pathogen signal in Arabidopsis

Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery

De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease

Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness

NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes

A promising platform for predicting toxicity

A quadratic model captures the human V1 response to variations in chromatic direction and contrast

Novel neuroanatomical integration and scaling define avian brain shape evolution and development

Image3C, a multimodal image-based and label-independent integrative method for single-cell analysis

Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

Disrupting enzyme fluidity

Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

Correction: Structural basis of phosphatidylcholine recognition by the C2-Domain of cytosolic phospholipase A2α

Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis

Sex differences in biological aging with a focus on human studies

The structure of photosystem I from a high-light-tolerant cyanobacteria

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex

A nuclear-based quality control pathway for non-imported mitochondrial proteins

Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages

First-principles model of optimal translation factors stoichiometry

Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

Generation and diversification of recombinant monoclonal antibodies

A critical residue in the α1M2–M3 linker regulating mammalian GABAA receptor pore gating by diazepam

Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion

Understanding the evolution of multiple drug resistance in structured populations

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

Memory recall involves a transient break in excitatory-inhibitory balance

The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations

Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses

Extreme suction attachment performance from specialised insects living in mountain streams (Diptera: Blephariceridae)

HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

Witnessing the structural evolution of an RNA enzyme

Social groups buffer maternal loss in mountain gorillas

PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling

Structure and function of axo-axonic inhibition

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Separable neural signatures of confidence during perceptual decisions

Temperature-dependent fasciation mutants provide a link between mitochondrial RNA processing and lateral root morphogenesis

Competitive coordination of the dual roles of the Hedgehog co-receptor in homophilic adhesion and signal reception

Modeling transfer of vaginal microbiota from mother to infant in early life

The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts

A pre-screening strategy to assess resected tumor margins by imaging cytoplasmic viscosity and hypoxia

A retrospective analysis of the peer review of more than 75,000 Marie Curie proposals between 2007 and 2018

A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci

PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR

The population genetics of collateral resistance and sensitivity

A helicase-tethered ORC flip enables bidirectional helicase loading

Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

Pathway dynamics can delineate the sources of transcriptional noise in gene expression

The organizational principles of de-differentiated topographic maps in somatosensory cortex

Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling

Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals

Crosstalk between the chloroplast protein import and SUMO systems revealed through genetic and molecular investigation in Arabidopsis

Plant-associated CO2 mediates long-distance host location and foraging behaviour of a root herbivore

Characterizing human mobility patterns in rural settings of sub-Saharan Africa

Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

Excitation of medium spiny neurons by 'inhibitory' ultrapotent chemogenetics via shifts in chloride reversal potential

Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice

Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua

Emergence and function of cortical offset responses in sound termination detection

A gradient of Wnt activity positions the neurosensory domains of the inner ear

Nonlinear transient amplification in recurrent neural networks with short-term plasticity

T cell self-reactivity during thymic development dictates the timing of positive selection

Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

Basis of specificity for a conserved and promiscuous chromatin remodeling protein

Social contact patterns and implications for infectious disease transmission – a systematic review and meta-analysis of contact surveys

Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis

Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

Interrogating theoretical models of neural computation with emergent property inference

Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2

Sensitivity of ID NOW and RT–PCR for detection of SARS-CoV-2 in an ambulatory population

Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS

In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

Fusion of tethered membranes can be driven by Sec18/NSF and Sec17/αSNAP without HOPS

Circuits for integrating learned and innate valences in the insect brain

Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat

Correction: RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

The molecular basis of coupling between poly(A)-tail length and translational efficiency

A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation

High rates of evolution preceded shifts to sex-biased gene expression in Leucadendron, the most sexually dimorphic angiosperms

Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans

The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis

EEG-based detection of the locus of auditory attention with convolutional neural networks

A call to eradicate non-inclusive terms from the life sciences

A subcellular map of the human kinome

The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle

Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis

ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

Neural signatures of vigilance decrements predict behavioural errors before they occur

Calponin-homology domain mediated bending of membrane-associated actin filaments

Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

Genetic code expansion enables visualization of Salmonella type three secretion system components and secreted effectors

Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts

LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

Spontaneous and evoked activity patterns diverge over development

Drosophila uses a tripod gait across all walking speeds, and the geometry of the tripod is important for speed control

Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

Climate-driven deoxygenation elevates fishing vulnerability for the ocean's widest ranging shark

3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images

Microbial genetic and transcriptional contributions to oxalate degradation by the gut microbiota in health and disease

High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism

Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy

The brain limit

Development of antibacterial compounds that constrain evolutionary pathways to resistance

Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

Electrical synaptic transmission requires a postsynaptic scaffolding protein

The causal role of auditory cortex in auditory working memory

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

Robust vestibular self-motion signals in macaque posterior cingulate region

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

Brain endothelial cell TRPA1 channels initiate neurovascular coupling

Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway

Propensity for somatic expansion increases over the course of life in Huntington disease

Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

Niche partitioning facilitates coexistence of closely related honey bee gut bacteria

A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

Temporally delayed linear modelling (TDLM) measures replay in both animals and humans

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

Tuning self-renewal in the Arabidopsis stomatal lineage by hormone and nutrient regulation of asymmetric cell division

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

The pattern of nodal morphogen signaling is shaped by co-receptor expression

Evolutionary dynamics of circular RNAs in primates

The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

Working memory gates visual input to primate prefrontal neurons

Neural basis of corruption in power-holders

Bone age is not just for kids

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

Studying evolution of the primary body axis in vivo and in vitro

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data

Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons

Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels

Little evidence that Eurasian jays protect their caches by responding to cues about a conspecific's desire and visual perspective

Global epistasis emerges from a generic model of a complex trait

Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

Parallel functional testing identifies enhancers active in early postnatal mouse brain

TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states

A computational screen for alternative genetic codes in over 250,000 genomes

Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience

Behavioral evidence for nested central pattern generator control of Drosophila grooming

Multicolor fluorescence fluctuation spectroscopy in living cells via spectral detection

Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

Physiology and ecology combine to determine host and vector importance for Ross River virus

Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection

A morphological transformation in respiratory syncytial virus leads to enhanced complement deposition

Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord

Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

Receptor-mediated mitophagy regulates EPO production and protects against renal anemia

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria

Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Structural basis for transcription complex disruption by the Mfd translocase

Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish

Neuronal activity in dorsal anterior cingulate cortex during economic choices under variable action costs

A move in the light direction

Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling

Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

Cycles, sources, and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks

Dissociation of task engagement and arousal effects in auditory cortex and midbrain

Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

Structural basis of the effect of activating mutations on the EGF receptor

Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

A spinoparabrachial circuit defined by Tacr1 expression drives pain

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance

Sequential perturbations to mouse corticogenesis following in utero maternal immune activation

Evolution of cytokine production capacity in ancient and modern European populations

Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

A projectome of the bumblebee central complex

A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

Enhanced specificity mutations perturb allosteric signaling in CRISPR-Cas9

An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

Pak1 kinase controls cell shape through ribonucleoprotein granules

Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription

A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

Social-like responses are inducible in asocial Mexican cavefish despite the exhibition of strong repetitive behavior

A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

Mother brain is wired for social moments

Introducing the MAVEN Leadership Training Initiative to diversify the scientific workforce

Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health

Information content differentiates enhancers from silencers in mouse photoreceptors

Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization

Single-molecule view of coordination in a multi-functional DNA polymerase

Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

Investigating the replicability of preclinical cancer biology

A causal role for the right frontal eye fields in value comparison

Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes

6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

Deficient spermiogenesis in mice lacking Rlim

The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions

Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

Connectional asymmetry of the inferior parietal lobule shapes hemispheric specialization in humans, chimpanzees, and rhesus macaques

The biomechanical role of extra-axonemal structures in shaping the flagellar beat of Euglena gracilis

HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

Double-μPeriscope, a tool for multilayer optical recordings, optogenetic stimulations or both

A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output in male mice

The two roles of complex III in plants

Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia

Rat sensitivity to multipoint statistics is predicted by efficient coding of natural scenes

Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates

Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates

ARL3 activation requires the co-GEF BART and effector-mediated turnover

Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport

Stimulus-specific plasticity in human visual gamma-band activity and functional connectivity

Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance

Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila

Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment

Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori

Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function

Preserved sensory processing but hampered conflict detection when stimulus input is task-irrelevant

Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape

SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients

KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance

Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

Framework for rapid comparison of extracellular vesicle isolation methods

A naturalistic environment to study visual cognition in unrestrained monkeys

Physiological and motion signatures in static and time-varying functional connectivity and their subject identifiability

In-host population dynamics of Mycobacterium tuberculosis complex during active disease

pH-dependent 11° F1FO ATP synthase sub-steps reveal insight into the FO torque generating mechanism

Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

Functional insights from a surface antigen mRNA-bound proteome

miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

MITF reprograms the extracellular matrix and focal adhesion in melanoma

High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila

Neuropsychological evidence of multi-domain network hubs in the human thalamus

Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

Early maternal loss leads to short- but not long-term effects on diurnal cortisol slopes in wild chimpanzees

Modulation of fracture healing by the transient accumulation of senescent cells

E2F/Dp inactivation in fat body cells triggers systemic metabolic changes

TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

Integrative frontal-parietal dynamics supporting cognitive control

The critical importance of vouchers in genomics

Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

Epidemiological transition to mortality and refracture following an initial fracture

The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics

Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila

Adaptation of spontaneous activity in the developing visual cortex

Analysis of long and short enhancers in melanoma cell states

Inbreeding in a dioecious plant has sex- and population origin-specific effects on its interactions with pollinators

Structural variability and concerted motions of the T cell receptor – CD3 complex

The final step of 40S ribosomal subunit maturation is controlled by a dual key lock

Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

Ir56d-dependent fatty acid responses in Drosophila uncover taste discrimination between different classes of fatty acids

How infectious diseases arrived in the colonial Americas

Activity-dependent regulation of mitochondrial motility in developing cortical dendrites

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains

Early life experience sets hard limits on motor learning as evidenced from artificial arm use

Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes

Control of feeding by Piezo-mediated gut mechanosensation in Drosophila

PomX, a ParA/MinD ATPase activating protein, is a triple regulator of cell division in Myxococcus xanthus

Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length

Individual variation in Achilles tendon morphology and geometry changes susceptibility to injury

A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression

Anopheles salivary antigens as serological biomarkers of vector exposure and malaria transmission: A systematic review with multilevel modelling

Dynamic Na+/H+ exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations

Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

Preliminary paleohistological observations of the StW 573 ('Little Foot') skull

A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation

A high rate of COVID-19 vaccine hesitancy in a large-scale survey on Arabs

Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

A small, computationally flexible network produces the phenotypic diversity of song recognition in crickets

Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

SUMO is a pervasive regulator of meiosis

Cortical signatures of precision grip force control in children, adolescents, and adults

Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae

In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

Mesoscale phase separation of chromatin in the nucleus

Opioid antagonism modulates wanting-related frontostriatal connectivity

Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements

Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a

Proton transfer pathway in anion channelrhodopsin-1

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila

Motor planning under uncertainty

From local resynchronization to global pattern recovery in the zebrafish segmentation clock

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity

GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

Structure and mechanistic features of the prokaryotic minimal RNase P

MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs

Modality-specific tracking of attention and sensory statistics in the human electrophysiological spectral exponent

An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET

The Arabidopsis active demethylase ROS1 cis-regulates defence genes by erasing DNA methylation at promoter-regulatory regions

Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing

Human primed ILCPs support endothelial activation through NF-κB signaling

A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process

The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease

Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human

A functional genetic toolbox for human tissue-derived organoids

Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering

Fast and accurate annotation of acoustic signals with deep neural networks

One-shot analysis of translated mammalian lncRNAs with AHARIBO

Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

Release probability increases towards distal dendrites boosting high-frequency signal transfer in the rodent hippocampus

Locating macromolecular assemblies in cells by 2D template matching with cisTEM

Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem

Decoding locomotion from population neural activity in moving C. elegans

Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA

The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

Building a community to engineer synthetic cells and organelles from the bottom-up

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

A survey of early-career researchers in Australia

Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

Molecular characterization of projection neuron subtypes in the mouse olfactory bulb

The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

Glycan-based shaping of the microbiota during primate evolution

Sex differences in learning from exploration

Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway

Urgency forces stimulus-driven action by overcoming cognitive control

The temporal representation of experience in subjective mood

Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders

Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia

Drp1 is required for AgRP neuronal activity and feeding

Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

The development of active binocular vision under normal and alternate rearing conditions

Molecular reconstruction of recurrent evolutionary switching in olfactory receptor specificity

3D cell neighbour dynamics in growing pseudostratified epithelia

Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2

Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

Enhanced Cas12a multi-gene regulation using a CRISPR array separator

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

Analysis of ultrasonic vocalizations from mice using computer vision and machine learning

The effect of host community functional traits on plant disease risk varies along an elevational gradient

A framework for studying behavioral evolution by reconstructing ancestral repertoires

Relative demographic susceptibility does not explain the extinction chronology of Sahul's megafauna

Hyaluronic acid fuels pancreatic cancer cell growth

Sleeping at the switch

Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites

Early evolution of beetles regulated by the end-Permian deforestation

HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection wave

Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

Asprosin-neutralizing antibodies as a treatment for metabolic syndrome

A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY

The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

Increasing human motor skill acquisition by driving theta–gamma coupling

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

The inner mechanics of rhodopsin guanylyl cyclase during cGMP-formation revealed by real-time FTIR spectroscopy

Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

Dynamic decision policy reconfiguration under outcome uncertainty

Action detection using a neural network elucidates the genetics of mouse grooming behavior

Mice in a labyrinth show rapid learning, sudden insight, and efficient exploration

Crosstalk between nitric oxide and retinoic acid pathways is essential for amphioxus pharynx development

Activity-dependent modulation of synapse-regulating genes in astrocytes

The elusive perspective of a food thief

Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli

Toxins, mutations and adaptations

In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography

ORACLE reveals a bright future to fight bacteria

Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking

Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans

Human complex exploration strategies are enriched by noradrenaline-modulated heuristics

Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis

Assessing target engagement using proteome-wide solvent shift assays

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains

3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase

A mechanistic model for long-term immunological outcomes in South African HIV-infected children and adults receiving ART

Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods

An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

Protective function and durability of mouse lymph node-resident memory CD8+ T cells

Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics

In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

Clustered functional domains for curves and corners in cortical area V4

Effects of arousal and movement on secondary somatosensory and visual thalamus

Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

SUV39 SET domains mediate crosstalk of heterochromatic histone marks

Theory for the optimal detection of time-varying signals in cellular sensing systems

Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm

Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics

Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia

A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates

Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

Going beyond lifestyle factors

Antimicrobial resistance and COVID-19: Intersections and implications

DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation

Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

Inequalities in the distribution of National Institutes of Health research project grant funding

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia

Proteomics reveals synergy between biomass degrading enzymes and inorganic Fenton chemistry in leaf-cutting ant colonies

Control of parallel hippocampal output pathways by amygdalar long-range inhibition

Non-genetic inheritance restraint of cell-to-cell variation

Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis

An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time

Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking

An evidence-based 3D reconstruction of Asteroxylon mackiei, the most complex plant preserved from the Rhynie chert

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

Transcription initiation at a consensus bacterial promoter proceeds via a 'bind-unwind-load-and-lock' mechanism

Open science takes on Parkinson's disease

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

A hypothesis on the capacity of plant odorant-binding proteins to bind volatile isoprenoids based on in silico evidences

Causal roles of prefrontal cortex during spontaneous perceptual switching are determined by brain state dynamics

Columnar processing of border ownership in primate visual cortex

Infection with a newly designed dual fluorescent reporter HIV-1 effectively identifies latently infected CD4+ T cells

Thermal acclimation of tropical coral reef fishes to global heat waves

Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

Regularities in species' niches reveal the world's climate regions

The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

5′-Modifications improve potency and efficacy of DNA donors for precision genome editing

The severity of microstrokes depends on local vascular topology and baseline perfusion

Correction: Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

microRNA-mediated regulation of microRNA machinery controls cell fate decisions

Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

Development of visual motion integration involves coordination of multiple cortical stages

Freshwater monitoring by nanopore sequencing

Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

Synaptic learning rules for sequence learning

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

Propelling and perturbing appendages together facilitate strenuous ground self-righting

Genetic depletion studies inform receptor usage by virulent hantaviruses in human endothelial cells

Telomere length is associated with growth in children in rural Bangladesh

Exploring risk factors at the molecular level

Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

Model-based spatial-temporal mapping of opisthorchiasis in endemic countries of Southeast Asia

Confinement discerns swarmers from planktonic bacteria

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil

Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties

Sensory coding and the causal impact of mouse cortex in a visual decision

Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

Cell-scale biophysical determinants of cell competition in epithelia

7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons

Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

Rapid mechanical stimulation of inner-ear hair cells by photonic pressure

Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

The roles of history, chance, and natural selection in the evolution of antibiotic resistance

Distinct dendritic Ca2+ spike forms produce opposing input-output transformations in rat CA3 pyramidal cells

Stability of neocortical synapses across sleep and wake states during the critical period in rats

Stimulus-induced gamma rhythms are weaker in human elderly with mild cognitive impairment and Alzheimer's disease

Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells

Tracking the relation between gist and item memory over the course of long-term memory consolidation

Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world

Evolution of the complex transcription network controlling biofilm formation in Candida species

Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality

Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei

Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA

NMDA receptors control development of somatosensory callosal axonal projections

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

Mapping the visual world to the human brain

Strong confinement of active microalgae leads to inversion of vortex flow and enhanced mixing

When the past informs our future

A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

Sniff-synchronized, gradient-guided olfactory search by freely moving mice

Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells

Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

An open-source, high-performance tool for automated sleep staging

ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

Cross-compartment signal propagation in the mitotic exit network

Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates

Optimal policy for attention-modulated decisions explains human fixation behavior

A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites

Highly parallelized droplet cultivation and prioritization of antibiotic producers from natural microbial communities

Neural excitability and sensory input determine intensity perception with opposing directions in initial cortical responses

Injection with Toxoplasma gondii protein affects neuron health and survival

Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

The diversity and function of sourdough starter microbiomes

Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans

Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation

Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

RNase III-mediated processing of a trans-acting bacterial sRNA and its cis-encoded antagonist

Investigating disagreement in the scientific literature

Why flies look to the skies

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell

Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses

Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress

Robust, coherent, and synchronized circadian clock-controlled oscillations along Anabaena filaments

Molecular structures of the eukaryotic retinal importer ABCA4

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

Microbiome-pathogen interactions drive epidemiological dynamics of antibiotic resistance: A modeling study applied to nosocomial pathogen control

Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

CRISPR-based functional genomics in human dendritic cells

In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout the C. elegans nervous system

Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation

Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials

Taming the beasts inside

No relationship between frontal alpha asymmetry and depressive disorders in a multiverse analysis of five studies

Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

High social status males experience accelerated epigenetic aging in wild baboons

An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface

Switch-like control of helicase processivity by single-stranded DNA binding protein

De novo learning versus adaptation of continuous control in a manual tracking task

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

Dietary nitrate supplementation prevents radiotherapy-induced xerostomia

Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum

Rigorous review and editorial oversight of clinical preprints

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

Robustness of the microtubule network self-organization in epithelia

Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

A fungal member of the Arabidopsis thaliana phyllosphere antagonizes Albugo laibachii via a GH25 lysozyme

Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice

Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

Genomic epidemiology of COVID-19 in care homes in the east of England

Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments

Perception of microstimulation frequency in human somatosensory cortex

Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

Correct regionalization of a tissue primordium is essential for coordinated morphogenesis

Alternative strategies for closing the award gap between white and minority ethnic students

Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model

High-resolution, genome-wide mapping of positive supercoiling in chromosomes

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

Variability in the Munc13-1 content of excitatory release sites

Distinct higher-order representations of natural sounds in human and ferret auditory cortex

A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis

What if we just give everything away?

How lung cancer cells change identity

Retraction: Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines

Autoregulatory control of microtubule binding in doublecortin-like kinase 1

An integrative study of five biological clocks in somatic and mental health

Global constraints within the developmental program of the Drosophila wing

Local adaptation and archaic introgression shape global diversity at human structural variant loci

Histone H1 prevents non-CG methylation-mediated small RNA biogenesis in Arabidopsis heterochromatin

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis

NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

Sequence structure organizes items in varied latent states of working memory neural network

Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis

Proposed therapy, developed in a Pcdh15-deficient mouse, for progressive loss of vision in human Usher syndrome

Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb

The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo

An open label trial of anakinra to prevent respiratory failure in COVID-19

Bi-channel image registration and deep-learning segmentation (BIRDS) for efficient, versatile 3D mapping of mouse brain

Exposure to landscape fire smoke reduced birthweight in low- and middle-income countries: findings from a siblings-matched case-control study

Modeling spinal locomotor circuits for movements in developing zebrafish

Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo

Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication

Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength

A new era for research into aging

An evolutionary model identifies the main evolutionary biases for the evolution of genome-replication profiles

Coupling between fast and slow oscillator circuits in Cancer borealis is temperature-compensated

Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis

Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever

Reporting and misreporting of sex differences in the biological sciences

Diverse inhibitory projections from the cerebellar interposed nucleus

Oxygen overload

Correction: Bi-channel image registration and deep-learning segmentation (BIRDS) for efficient, versatile 3D mapping of mouse brain

VASP-mediated actin dynamics activate and recruit a filopodia myosin

Multiple neuronal networks coordinate Hydra mechanosensory behavior

Misic, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities

Crash landing of Vibrio cholerae by MSHA pili-assisted braking and anchoring in a viscoelastic environment

Spatial tuning of face part representations within face-selective areas revealed by high-field fMRI

Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

Integron activity accelerates the evolution of antibiotic resistance

The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

Respiration aligns perception with neural excitability

A theory of synaptic transmission

Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Nanoscape, a data-driven 3D real-time interactive virtual cell environment

mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells

Circular RNA repertoires are associated with evolutionarily young transposable elements

Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

Evolution of irreversible somatic differentiation

Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria

Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

Identification of distinct pH- and zeaxanthin-dependent quenching in LHCSR3 from Chlamydomonas reinhardtii

Value signals guide abstraction during learning

Truth even unto its innermost parts

Robust and distributed neural representation of action values

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition

Unconventional conservation reveals structure-function relationships in the synaptonemal complex

The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

Unexpected plasticity in the life cycle of Trypanosoma brucei

The discriminatory power of the T cell receptor

Brain functional networks associated with social bonding in monogamous voles

Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

A transient postnatal quiescent period precedes emergence of mature cortical dynamics

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma

An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi

Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

Echolocating toothed whales use ultra-fast echo-kinetic responses to track evasive prey

Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies

A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world's smallest mammalian divers

Increased influence of prior choices on perceptual decisions in autism

Endoplasmic reticulum tubules limit the size of misfolded protein condensates

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Y chromosome functions in mammalian spermatogenesis

Neural dynamics between anterior insular cortex and right supramarginal gyrus dissociate genuine affect sharing from perceptual saliency of pretended pain

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

A visual pathway for skylight polarization processing in Drosophila

The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

How oscillating aerodynamic forces explain the timbre of the hummingbird's hum and other animals in flapping flight

β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

Challenges for assessing replicability in preclinical cancer biology

Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

Diversity and asynchrony in soil microbial communities stabilizes ecosystem functioning

Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

A new kind of beat

Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis

Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Heterogeneity of murine periosteum progenitors involved in fracture healing

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

Switch-like and persistent memory formation in individual Drosophila larvae

Collateral sensitivity associated with antibiotic resistance plasmids

Should I stay or should I go?

Ovipositor and mouthparts in a fossil insect support a novel ecological role for early orthopterans in 300 million years old forests

SABRE populates ER domains essential for cell plate maturation and cell expansion influencing cell and tissue patterning

The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum

Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

TRPM channels mediate learned pathogen avoidance following intestinal distention

Protective mitochondrial fission induced by stress-responsive protein GJA1-20k

Synthesis of a comprehensive population code for contextual features in the awake sensory cortex

Standardizing workflows in imaging transcriptomics with the abagen toolbox

The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice

Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis

Spatial modulation of individual behaviors enables an ordered structure of diverse phenotypes during bacterial group migration

Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Environmental fluctuations reshape an unexpected diversity-disturbance relationship in a microbial community

How subtle changes in 3D structure can create large changes in transcription

A parameter-free statistical test for neuronal responsiveness

A genome-phenome association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

Spatially patterned excitatory neuron subtypes and projections of the claustrum

Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential

Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate

Seroconversion stages COVID19 into distinct pathophysiological states

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

Galectin-9 regulates the threshold of B cell activation and autoimmunity

Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion

Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

Identification of drugs associated with reduced severity of COVID-19 – a case-control study in a large population

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells

Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum–mitochondria associations

Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond

Genetic variant in 3' untranslated region of the mouse pycard gene regulates inflammasome activity

Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

Properties of multivesicular release from mouse rod photoreceptors support transmission of single-photon responses

Non-canonical role for Lpar1-EGFP subplate neurons in early postnatal mouse somatosensory cortex

Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

Shore crabs reveal novel evolutionary attributes of the mushroom body

Identification of host proteins differentially associated with HIV-1 RNA splice variants

A 3D adult zebrafish brain atlas (AZBA) for the digital age

Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons

Design issues and solutions for stop-signal data from the Adolescent Brain Cognitive Development (ABCD) study

Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase

Highly contiguous assemblies of 101 drosophilid genomes

Simplifying the development of portable, scalable, and reproducible workflows

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung

Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage

Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy

Residue-by-residue analysis of cotranslational membrane protein integration in vivo

Self-organized patterning of cell morphology via mechanosensitive feedback

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

Quantitative spatial and temporal assessment of regulatory element activity in zebrafish

Biomarkers in a socially exchanged fluid reflect colony maturity, behavior, and distributed metabolism

The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

Contingency and chance erase necessity in the experimental evolution of ancestral proteins

Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen

Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets

The human cerebellum is essential for modulating perceptual sensitivity based on temporal expectations

Partial connectomes of labeled dopaminergic circuits reveal non-synaptic communication and axonal remodeling after exposure to cocaine

Adiponectin preserves metabolic fitness during aging

Specialized coding patterns among dorsomedial prefrontal neuronal ensembles predict conditioned reward seeking

The OpenNeuro resource for sharing of neuroscience data

Genomic and healthcare dynamics of nosocomial SARS-CoV-2 transmission

Gap junction-mediated glycinergic inhibition ensures precise temporal patterning in vocal behavior

Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex

Volatile DMNT directly protects plants against Plutella xylostella by disrupting the peritrophic matrix barrier in insect midgut

Disintegration promotes protospacer integration by the Cas1-Cas2 complex

Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

Bacterial evolution on demand

Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

Evolving interpretable plasticity for spiking networks

Evolutionary footprints of a cold relic in a rapidly warming world

Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

Is preclinical research in cancer biology reproducible enough?

Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation

Uncovering a 'sensitive window' of multisensory and motor neuroplasticity in the cerebrum and cerebellum of male and female starlings

Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

Working memory capacity of crows and monkeys arises from similar neuronal computations

Rapid spread of a densovirus in a major crop pest following wide-scale adoption of Bt-cotton in China

EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

Survival of the glycosylated

Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53

Fully autonomous mouse behavioral and optogenetic experiments in home-cage

Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle

Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice

Rapid recycling of glutamate transporters on the astroglial surface

Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation

TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

The need for practical insecticide-resistance guidelines to effectively inform mosquito-borne disease control programs

Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

Uniparental nuclear inheritance following bisexual mating in fungi

SSNA1 stabilizes dynamic microtubules and detects microtubule damage

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish

Modulation of pulsatile GnRH dynamics across the ovarian cycle via changes in the network excitability and basal activity of the arcuate kisspeptin network

Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

Common virulence gene expression in adult first-time infected malaria patients and severe cases

Microtubule reorganization during female meiosis in C. elegans

Place-cell capacity and volatility with grid-like inputs

Performance in even a simple perceptual task depends on mouse secondary visual areas

Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

Modelling the neural code in large populations of correlated neurons

A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus

Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

Discovery and characterization of Hv1-type proton channels in reef-building corals

Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

Pioneer neutrophils release chromatin within in vivo swarms

An in vitro stem cell model of human epiblast and yolk sac interaction

Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

Mutation saturation for fitness effects at human CpG sites

Multiple time-scales of decision-making in the hippocampus and prefrontal cortex

High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons

Saliva TwoStep for rapid detection of asymptomatic SARS-CoV-2 carriers

Filopodia powered by class x myosin promote fusion of mammalian myoblasts

Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

Structure and ion-release mechanism of PIB-4-type ATPases

Hypoxia triggers collective aerotactic migration in Dictyostelium discoideum

Evolution of brilliant iridescent feather nanostructures

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

Disrupting cortico-cerebellar communication impairs dexterity

Remote immune processes revealed by immune-derived circulating cell-free DNA

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

A catalyst for change

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells

Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses

Group phenotypic composition in cancer

The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

To lie or not to lie: Super-relaxing with myosins

AAV ablates neurogenesis in the adult murine hippocampus

Human MAIT cells respond to and suppress HIV-1

Quantitative analysis of tumour spheroid structure

Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

Relationships between community composition, productivity and invasion resistance in semi-natural bacterial microcosms

Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

Watching hair turn grey

Uncovering the computational mechanisms underlying many-alternative choice

Decoding the physical principles of two-component biomolecular phase separation

Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

Corticothalamic gating of population auditory thalamocortical transmission in mouse

Mapping brain-behavior space relationships along the psychosis spectrum

A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

Stochastic social behavior coupled to COVID-19 dynamics leads to waves, plateaus, and an endemic state

Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope

BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice

Scaling of subcellular actin structures with cell length through decelerated growth

Signed and unsigned reward prediction errors dynamically enhance learning and memory

Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center

Deciphering the triad of infection, immunity and pathology

Blinding peer review

The energetic basis for smooth human arm movements

Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

Differential dopaminergic modulation of spontaneous cortico–subthalamic activity in Parkinson's disease

A modular platform for automated cryo-FIB workflows

Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons

Gaps in global wildlife trade monitoring leave amphibians vulnerable

Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis

Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

Common host variation drives malaria parasite fitness in healthy human red cells

Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay

Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells

Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility

ZC3H4 restricts non-coding transcription in human cells

Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model

A dual endosymbiosis supports nutritional adaptation to hematophagy in the invasive tick Hyalomma marginatum

Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis

Unraveling the history of limb bones

Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

PGFinder, a novel analysis pipeline for the consistent, reproducible, and high-resolution structural analysis of bacterial peptidoglycans

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron

Exploring the origins of nucleation

Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions

Morphological and genomic shifts in mole-rat 'queens' increase fecundity but reduce skeletal integrity

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

A modular approach to integrating multiple data sources into real-time clinical prediction for pediatric diarrhea

V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission

A robust method for particulate detection of a genetic tag for 3D electron microscopy

Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism

DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

Early prediction of in-hospital death of COVID-19 patients: a machine-learning model based on age, blood analyses, and chest x-ray score

Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury

Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

How will mosquitoes adapt to climate warming?

Local genetic context shapes the function of a gene regulatory network

Evolutionary medicine

What can we learn from honey bees?

Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses

Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing

Bardet–Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome

Rampant tooth loss across 200 million years of frog evolution

An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

Social fluidity mobilizes contagion in human and animal populations

Anatomy and activity patterns in a multifunctional motor neuron and its surrounding circuits

Presynaptic stochasticity improves energy efficiency and helps alleviate the stability-plasticity dilemma

Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans

Mapping the endemicity and seasonality of clinical malaria for intervention targeting in Haiti using routine case data

The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

Unsupervised changes in core object recognition behavior are predicted by neural plasticity in inferior temporal cortex

Tissue-specific targeting of DNA nanodevices in a multicellular living organism

Heterogeneous side effects of cortical inactivation in behaving animals

Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism

Impact of asymptomatic Plasmodium falciparum infection on the risk of subsequent symptomatic malaria in a longitudinal cohort in Kenya

Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node

Phasic oxygen dynamics confounds fast choline-sensitive biosensor signals in the brain of behaving rodents

Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

Cortical magnification in human visual cortex parallels task performance around the visual field

Src activates retrograde membrane traffic through phosphorylation of GBF1

EGFR transactivates RON to drive oncogenic crosstalk

Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway

Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

The neural basis of intelligence in fine-grained cortical topographies

Correction: Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain

Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

Signaling levels mold the RAS mutation tropism of urethane

Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina

Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness

Loss of a co-twin at birth and subsequent risk of psychiatric disorders

Effect of malaria parasite shape on its alignment at erythrocyte membrane

Shape-invariant encoding of dynamic primate facial expressions in human perception

Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis

Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex

Western diet shifts immune cell balance

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in Vibrio cholerae

fMRI-based detection of alertness predicts behavioral response variability

Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

Neuronal sequences during theta rely on behavior-dependent spatial maps

A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration

Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

Proof of concept for multiple nerve transfers to a single target muscle

Learning excitatory-inhibitory neuronal assemblies in recurrent networks

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development

Mapping single-cell atlases throughout Metazoa unravels cell type evolution

Atomic structures of respiratory complex III2, complex IV, and supercomplex III2-IV from vascular plants

Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

Response-based outcome predictions and confidence regulate feedback processing and learning

Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates

Correction: Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain

Linguistic processing of task-irrelevant speech at a cocktail party

Differential adhesion regulates neurite placement via a retrograde zippering mechanism

Determinants shaping the nanoscale architecture of the mouse rod outer segment

Different translation dynamics of β- and γ-actin regulates cell migration

Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

ATP activation of peritubular cells drives testicular sperm transport

When oncogenes do not cause cancer

The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

Perturbation of amygdala-cortical projections reduces ensemble coherence of palatability coding in gustatory cortex

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

Learning to stand with unexpected sensorimotor delays

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

Revisiting the guidelines for ending isolation for COVID-19 patients

Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling

Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation

Redefining innate natural antibodies as important contributors to anti-tumor immunity

Molecular machinery turns full circle

Sensory feedback can give rise to neural rotations

Transcriptional profiling of sequentially generated septal neuron fates

Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

Unite to predict

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

New light shed on the early evolution of limb-bone growth plate and bone marrow

The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer

Evolutionary conflicts and adverse effects of antiviral factors

Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination

Quantitative theory for the diffusive dynamics of liquid condensates

Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer

A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females

Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

A flagellate-to-amoeboid switch in the closest living relatives of animals

Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites

TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

Vision, challenges and opportunities for a Plant Cell Atlas

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast

Self-blinding citizen science to explore psychedelic microdosing

Hippocampal replay of experience at real-world speeds

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state

Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons

Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration

PARROT is a flexible recurrent neural network framework for analysis of large protein datasets

Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements

Hsp40s play complementary roles in the prevention of tau amyloid formation

Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells

Circadian regulation of vertebrate cone photoreceptor function

Host-associated microbe PCR (hamPCR) enables convenient measurement of both microbial load and community composition

Mimicry can drive convergence in structural and light transmission features of transparent wings in Lepidoptera

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

Epithelial colonies in vitro elongate through collective effects

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

A single synonymous nucleotide change impacts the male-killing phenotype of prophage WO gene wmk

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction

BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk

NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli

Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task

Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P.1 Brazilian variant

Starvation-induced regulation of carbohydrate transport at the blood–brain barrier is TGF-β-signaling dependent

Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity

Control and regulation of acetate overflow in Escherichia coli

Ciliary Hedgehog signaling regulates cell survival to build the facial midline

Homoplasy in the evolution of modern human-like joint proportions in Australopithecus afarensis

Microsecond interaural time difference discrimination restored by cochlear implants after neonatal deafness

Avoiding culture shock with the SARS-CoV-2 spike protein

A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe

ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e

Rare variants increase the risk of severe COVID-19

In silico-labeled ghost cytometry

Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection

End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

Emerging dynamics from high-resolution spatial numerical epidemics

Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

The mechanism underlying transient weakness in myotonia congenita

Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

Anticipation of temporally structured events in the brain

Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

An optimized CRISPR/Cas9 approach for precise genome editing in neurons

Cnidarian hair cell development illuminates an ancient role for the class IV POU transcription factor in defining mechanoreceptor identity

A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

A simple regulatory architecture allows learning the statistical structure of a changing environment

Ligand sensing enhances bacterial flagellar motor output via stator recruitment

Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

Piezo1 ion channels inherently function as independent mechanotransducers

Correction of amblyopia in cats and mice after the critical period

Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

Method development and characterisation of the low-molecular-weight peptidome of human wound fluids

Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

A confinable home-and-rescue gene drive for population modification

Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle

Transcriptomic encoding of sensorimotor transformation in the midbrain

How neurons adjust to diurnality

Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

Stem cell transplantation rescued a primary open-angle glaucoma mouse model

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population

FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip

3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways

RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

Detecting adaptive introgression in human evolution using convolutional neural networks

Neural control of growth and size in the axolotl limb regenerate

Behavioral control by depolarized and hyperpolarized states of an integrating neuron

Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans

High-quality carnivoran genomes from roadkill samples enable comparative species delineation in aardwolf and bat-eared fox

The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

A comprehensive look at the COVID-19 pandemic death toll

Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface

Dorsal periaqueductal gray ensembles represent approach and avoidance states

Laminar-specific cortico-cortical loops in mouse visual cortex

Distinct signatures of calcium activity in brain mural cells

Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants

Objective pupillometry shows that perceptual styles covary with autistic-like personality traits

Neuronal calmodulin levels are controlled by CAMTA transcription factors

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region

Emergence and diversification of a highly invasive chestnut pathogen lineage across southeastern Europe

Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

Evaluating distributional regression strategies for modelling self-reported sexual age-mixing

CDK1 controls CHMP7-dependent nuclear envelope reformation

Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

Recovery of consciousness and cognition after general anesthesia in humans

The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity

A population-level invasion by transposable elements triggers genome expansion in a fungal pathogen

COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest

New Caledonian crows keep 'valuable' hooked tools safer than basic non-hooked tools

Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation

Global gradients in intertidal species richness and functional groups

Getting the metabolites right

An oscillating computational model can track pseudo-rhythmic speech by using linguistic predictions

Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster

Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumen

Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans

Functional specialization within the inferior parietal lobes across cognitive domains

Visuomotor learning from postdictive motor error

KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

Reconsidering the evidence for learning in single cells

Quantifying the relationship between SARS-CoV-2 viral load and infectiousness

High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

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Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Yu-En Lin Chin-Hsien Lin En-Peng Ho Yi-Ci Ke Stavroula Petridi Christopher JH Elliott Lee-Yan Sheen Cheng-Ting Chien
Abstract	The most frequent missense mutations in familial Parkinson's disease (PD) occur in the highly conserved LRRK2/PARK8 gene with G2019S mutation. We previously established a fly model of PD carrying the LRRK2-G2019S mutation that exhibited the parkinsonism-like phenotypes. An herbal medicine, Gastrodia elata Blume (GE), has been reported to have neuroprotective effects in toxin-induced PD models. However, the underpinning molecular mechanisms of GE beneficiary to G2019S-induced PD remain unclear. Here, we show that these G2019S flies treated with water extracts of GE (WGE) and its bioactive compounds, gastrodin and 4-HBA, displayed locomotion improvement and dopaminergic neuron protection. WGE suppressed the accumulation and hyperactivation of G2019S proteins in dopaminergic neurons and activated the antioxidation and detoxification factor Nrf2 mostly in the astrocyte-like and ensheathing glia. Glial activation of Nrf2 antagonizes G2019S-induced Mad/Smad signaling. Moreover, we treated LRRK2-G2019S transgenic mice with WGE and found that the locomotion declines, the loss of dopaminergic neurons, and the number of hyperactive microglia were restored. WGE also suppressed the hyperactivation of G2019S proteins and regulated the Smad2/3 pathways in the mice brains. We conclude that WGE prevents locomotion defects and the neuronal loss induced by G2019S mutation via glial Nrf2/Mad signaling, unveiling a potential therapeutic avenue for PD.
e-ISSN	2050084X
DOI	10.7554/eLife.73753
Journal	eLife
Volume Number	10
Language	English
Publisher	eLife Sciences Publications Ltd
Publisher Date	2021-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Medicine Science Biology (general) Parkinson's Disease Lrrk2 Gastrodia Elata Blume Nrf2 Bmp/mad Glia
Content Type	Text
Resource Type	Article

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