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Sympathetic Stimulation and Hypertension in the Pyridoxine-Deficient Adult Rat
| Content Provider | CUSAT-Thesis |
|---|---|
| Author | Paulose, C. S. Dakshinamurti, K. Subah, Packer Newman, L. Stephens |
| Abstract | Pyridoxal phosphate is the coenzyme of various decarboxylases involved in the formationof monoamine neurotransmitters such as y-aminobutyric acid , serotonin , dopamine, and norepinephrine. Adult male Sprague-Dawley rats placed on a pyridoxine -deficient diet for 8 weeks showedsignificant hypertension compared with pyridoxine -supplemented controls . Hypothalamic contents ofpyridoxal phosphate , y-aminobutyric acid, and serotonin in the pyridoxine - deficient rats were significantlylower than those in pyridoxine -supplemented controls . Hypertension was associated withsympathetic stimulation . Treatment of pyridoxine-deficient rats with a single dose of pyridoxine (10mg/kg body weight) reversed the blood pressure to normal levels within 24 hours, with concomitantrestorations of hypothalamic serotonin and y-aminobutyric acid as well as the return of plasmanorepinephrine and epinephrine to normal levels . Also, pyridoxine treatment reversed the hypothalamichypothyroidism observed in pyridoxine -deficient rats . These results indicate an associationbetween pyridoxine deficiency and sympathetic stimulation leading to hypertension. |
| File Format | |
| Language | English |
| Publisher | Department of Biotechnology |
| Access Restriction | Open |
| Subject Keyword | Pyridoxine Serotonin y-aminobutyric acid Norepinephrine Blood pressure |
| Content Type | Text |
| Resource Type | Article |
