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Enhancement Of High Affinity Y-Aminobutyric Acid Receptor Binding In Cerebellum Of Pyridoxine-Deficient Rat
| Content Provider | CUSAT-Thesis |
|---|---|
| Author | Paulose, C. S. Dakshinamurti, K. |
| Abstract | The high-affinity of [3H]y-aminobutyric acid (GABA) to GABAA receptors and [3H]baclofen toGABAB receptors were studied in the cerebellum of pyridoxine-deficient rats and compared topyridoxine-supplemented controls. There was a significant increase in the maximal binding ( Bmax) of bothGABAA and GABAB receptors with no significant difference in their binding affinities (Kd). The changesobserved suggest a supersensitivity of GABAA and GABAB receptors which seems to correlate negativelywith the concentration of GABA in the cerebellum of pyridoxine-deficient rats. |
| File Format | |
| Language | English |
| Publisher | Department of Biotechnology |
| Access Restriction | Open |
| Subject Keyword | GABA receptor GABA binding GABAA receptor GABAB receptor |
| Content Type | Text |
| Resource Type | Article |