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Hypertension in Pyridoxine Deficiency
| Content Provider | CUSAT-Thesis |
|---|---|
| Author | Paulose, C. S. Dakshinamurti, K. Subah, Packer Newman, L. Stephens |
| Abstract | Pyridoxal phosphate (PLP) is the coenzyme of various decarboxylases involved in theformation of monoamine urotransmitters such as y-aminobulyric acid (GAE3A),serotonin (5-HT) and dopamine. 1-lowever; in the pyridoxine-deficient rats GABA and5-HT are decreased in various brain areas including the hypothalamus, with no changein the catecholamine levels. Serotonin and GABA are known to be involved in bloodpressure control mechanisms. In this study adult Sprague-Dawley rats placed on apyridoxine-deficient diet for 8 weeks showed significant hypertension compared withpyridoxine-supplemented controls. This was associated with a general sympatheticstimulation. Treatment of deficient rats with a single dose of pyridoxine (10 mg/kg bodyweight) reversed the blood pressure to normal levels within 24 h, with concomitantrestoration of hypothalamic 5-HT and GABA, as well as the return of plasmanorepinephrine to nornr;l levels. The results indicate that there is a cause-and-effectrelationship between pyridoxine deficiency and hypertension. |
| File Format | |
| Language | English |
| Publisher | Department of Biotechnology |
| Access Restriction | Open |
| Subject Keyword | Pyridoxine deficiency Serotonin y-anlinobutyric acid blood pressure |
| Content Type | Text |
| Resource Type | Article |