NDLI: Evaluation of Pulmonary Arterial Hypertension Using Computational Fluid Dynamics Simulation

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Evaluation of Pulmonary Arterial Hypertension Using Computational Fluid Dynamics Simulation

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Taherian, Shahab Rahai, Hamid Shin, Jamie Feldman, Jeremy Waddington, Thomas
Copyright Year	2017
Abstract	In silico study of the relationships between flow conditions, arterial surface shear stress, and pressure was investigated in a patient with pulmonary arterial hypertension (PAH), using multi-detector Computed Tomography Angiography (CTA) images and Computational Fluid Dynamics (CFD). The CTA images were converted into 3D models and transferred to CFD software for simulations, allowing for patient-specific comparisons between in silico results with clinical right heart catheterization pressure data. The simulations were performed using two different methods of outlet boundary conditions: zero traction and lumped parameter model (LPM) methods. Outlet pressures were set to a constant value in zero traction method, which can produce flow characteristics solely based on the segmented distal arteries, while the lumped parameter model used a three-element Windkessel lumped model to represent the distal vasculature by accounting for resistance, compliance, and impedance of the vasculature. Considering existing limitations with both approaches, it was found that the lumped parameter Windkessel outlet boundary condition provides a better correlation with the clinical RHC pressure results than the zero traction constant pressure outlet boundary condition.
File Format	PDF
ISBN	9780791858363
DOI	10.1115/IMECE2017-70193
Volume Number	Volume 3: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2017 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2017-11-03
Publisher Place	Tampa, Florida, USA
Access Restriction	Subscribed
Subject Keyword	Computational fluid dynamics Lumped parameter models Accounting Computer software Three-dimensional models Traction Pressure Flow (dynamics) Computerized tomography Simulation Shear stress Boundary-value problems Sensors
Content Type	Text
Resource Type	Article

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