NDLI: The Effect of Electrical Conductivity on Pore Resistance and Electroporation

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Li, Jianbo Lin, Hao
Copyright Year	2008
Abstract	Electroporation refers to the permeabilization of the cell membrane with one or multiple electric pulses. The reversible form of electroporation is widely applied for drug delivery, gene and cancer therapy, and stem cell research, among others; the irreversible form of electroporation is being explored for cancer treatment in a drug-free manner. In this work, an electroporation model is developed with particular focus on the prediction of pore resistance. The resulting formulation computes pore resistance as a function of pore size, and intracellular and extracellular conductivities, and avoids empirical or ad hoc specification of the conductivity of the pore-filling solution as practiced in previous works. Such a model is coupled at the whole cell level to investigate the effect of conductivity ratio on membrane permeabilization. The results reveal that the membrane achieves the maximum degree of permeabilization when the extracellular-to-intracellular conductivity ratio is around 0.5.
Starting Page	953
Ending Page	958
Page Count	6
File Format	PDF
ISBN	9780791848746
DOI	10.1115/IMECE2008-67773
e-ISBN	9780791838402
Volume Number	Volume 13: Nano-Manufacturing Technology; and Micro and Nano Systems, Parts A and B
Conference Proceedings	ASME 2008 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2008-10-31
Publisher Place	Boston, Massachusetts, USA
Access Restriction	Subscribed
Subject Keyword	Drugs Patient treatment Membranes Drug delivery systems Electrical conductivity Stem cells Electroporation Cell membranes Cancer
Content Type	Text
Resource Type	Article

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