NDLI: A Biaxial Shape Memory Alloy Actuated Cell/Tissue Stretching System

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Shan, Yingfeng Dodson, Jacob Abraham, Sheena John, E. Speich Rao, Raj Kam, K. Leang
Copyright Year	2007
Abstract	In this article, we describe the design of a shape memory alloy-based system to stretch cells cultured on top of a flexible membrane in multi-directions (longitudinal and transverse). Mechanical cues (such as strain and force) can affect the state and behavior of cells, such as, morphology, the differentiation process, and apoptosis. Therefore, a thorough understanding of the effects of mechanical perturbations on cells/tissues will have a deep impact in the biological sciences. The proposed design allows application of anisotropic (multi-axial) strain with high-precision. Certain cells, for example endothelial cells that line the inside of blood vessels, experience multi-axial (circumferential and longitudinal) stresses and strains. A cell stretching device that enables controlled application of biaxial strain will allow for systematic and accurate studies of the effects of externally applied mechanical perturbation throughout the cell, tissue, or organ. A preliminary design is proposed that exploits the strain recovery property of the shape memory alloy (SMA) actuators. We describe the design of the mechanical system and show experimental results to demonstrate stretching of a thin PDMS membrane in the longitudinal and transverse directions. To account for the inherent nonlinearity of the SMA, a feedback controller is implemented to achieve high-precision control of the stretching process. Additionally, the design can be integrated with an atomic force microscope (AFM) for high spatial and temporal resolution studies.
Starting Page	161
Ending Page	169
Page Count	9
File Format	PDF
ISBN	0791842967
DOI	10.1115/IMECE2007-42266
e-ISBN	0791838129
Volume Number	Volume 2: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2007 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2007-11-11
Publisher Place	Seattle, Washington, USA
Access Restriction	Subscribed
Subject Keyword	Atomic force microscopy Actuators Membranes Shape memory alloys Biological tissues Plasma desorption mass spectrometry Alloys Control equipment Blood vessels Endothelial cells Stress Design Anisotropy Feedback Life sciences Resolution (optics) Shapes
Content Type	Text
Resource Type	Article

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