NDLI: Controlled Cavitation and Sonoporation in Microfluidics

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Ohl, Claus-Dieter Gac, Se´verine Le Zwaan, Ed Tsuji, Kinko Berg, Albert Van Den
Copyright Year	2007
Abstract	Cavitation – the growth and collapse of mostly empty bubbles — is commonly attributed to large scale or very rapid flows, e.g. at ship propellors or at fuel injection nozzles. Cavitation is very aggressive to materials and one reason is its ability to focus fluid flows to very small scales; the bubbles concentrate the energy from the fluid during their shrinkage. Only recently the attention from largely free cavitation bubbles has shifted towards the study of more confined bubbles [1–5]. Here we report on an experiment to exploit cavitation in microfluidic systems or so called lab-on-a-chip devices for flow handling and biological cell manipulation. In microfluidics generally due to the small scales low Reynolds number flows are observed. Yet, cavitation bubble-induced flows allow to reach a high Reynolds number regime also on these small scales. By exploiting this rarely studied flow regime new techniques for liquid and cell handling become feasible. Here, we will report first on the effect of a channel wall on the bubble dynamics and then present an application for cell handling and membrane poration.
Starting Page	183
Ending Page	185
Page Count	3
File Format	PDF
ISBN	0791842967
DOI	10.1115/IMECE2007-41102
e-ISBN	0791838129
Volume Number	Volume 2: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2007 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2007-11-11
Publisher Place	Seattle, Washington, USA
Access Restriction	Subscribed
Subject Keyword	Collapse Membranes Fluid dynamics Reynolds number Shrinkage (materials) Fuels Cavitation Flow (dynamics) Biological cells Bubbles Fluids Dynamics (mechanics) Ships Nozzles Microfluidics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in