NDLI: Cerebrospinal Fluid Flow Impedance is Elevated in Type I Chiari Malformation

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Shaffer, Nicholas Martin, Bryn A. Rocque, Brandon Madura, Casey Iskandar, Bermans J. Wieben, Oliver Dombrowski, Stephen Luciano, Mark Oshinski, John N. Loth, Francis
Copyright Year	2014
Abstract	Diagnosis of Type I Chiari malformation (CMI) is difficult because the most commonly used diagnostic criterion, cerebellar tonsillar herniation (CTH) greater than 3–5 mm past the foramen magnum, has been found to have little correlation with patient symptom severity. Thus, there is a need to identify new objective measurement(s) to help quantify CMI severity. This study investigated longitudinal impedance (LI) as a parameter to assess CMI in terms of impedance to cerebrospinal fluid motion near the craniovertebral junction. LI was assessed in CMI patients (N = 15) and age-matched healthy controls (N = 8) using computational fluid dynamics based on subject-specific magnetic resonance imaging (MRI) measurements of the cervical spinal subarachnoid space. In addition, CTH was measured for each subject. Mean LI in the CMI group (551 ± 66 dyn/cm5) was significantly higher than in controls (220 ± 17 dyn/cm5, p < 0.001). Mean CTH in the CMI group was 9.0 ± 1.1 mm compared to −0.4 ± 0.5 mm in controls. Regression analysis of LI versus CTH found a weak relationship (R2 = 0.46, p < 0.001), demonstrating that CTH was not a good indicator of the impedance to CSF motion caused by cerebellar herniation. These results showed that CSF flow impedance was elevated in CMI patients and that LI provides different information than a standard CTH measurement. Further research is necessary to determine if LI can be useful in CMI patient diagnosis.
Starting Page	021012
Ending Page	021018
Page Count	7
File Format	PDF
ISSN	01480731
e-ISSN	15288951
Journal	Journal of Biomechanical Engineering
Volume Number	136
Issue Number	2
DOI	10.1115/1.4026316
Language	English
Publisher	The American Society of Mechanical Engineers
Publisher Date	2014-02-05
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Boundary-value problems Cerebrospinal fluid Computational fluid dynamics Flow (Dynamics) Magnetic resonance imaging Modeling
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biomedical Engineering

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