NDLI: The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Hwang, Priscilla Y. Chen, Jun Jing, Liufang Hoffman, Brenton D. Setton, Lori A.
Copyright Year	2014
Abstract	Intervertebral disc (IVD) disorders are a major contributor to disability and societal health care costs. Nucleus pulposus (NP) cells of the IVD exhibit changes in both phenotype and morphology with aging-related IVD degeneration that may impact the onset and progression of IVD pathology. Studies have demonstrated that immature NP cell interactions with their extracellular matrix (ECM) may be key regulators of cellular phenotype, metabolism and morphology. The objective of this article is to review our recent experience with studies of NP cell-ECM interactions that reveal how ECM cues can be manipulated to promote an immature NP cell phenotype and morphology. Findings demonstrate the importance of a soft (<700 Pa), laminin-containing ECM in regulating healthy, immature NP cells. Knowledge of NP cell-ECM interactions can be used for development of tissue engineering or cell delivery strategies to treat IVD-related disorders.
Starting Page	021010
Ending Page	021019
Page Count	10
File Format	PDF
ISSN	01480731
e-ISSN	15288951
Journal	Journal of Biomechanical Engineering
Volume Number	136
Issue Number	2
DOI	10.1115/1.4026360
Language	English
Publisher	The American Society of Mechanical Engineers
Publisher Date	2014-02-05
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biological tissues Biomedical engineering Elasticity Intervertebral discs Proteins Stress
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biomedical Engineering

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The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review

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The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review

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The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review

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The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review