NDLI: Sequential-Digital Image Correlation for Mapping Human Posterior Sclera and Optic Nerve Head Deformation

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Pyne, Jeffrey D. Genovese, Katia Casaletto, Luciana Geest, Jonathan P. Vande
Copyright Year	2014
Abstract	Optic nerve head (ONH) deformations may be involved in the onset or further development of glaucoma, including in patients with relatively normal intraocular pressures (IOPs). Characterizing posterior scleral deformations over physiological pressures may provide a better understanding of how changes in IOP lead to changes in the mechanical environment of the ONH and possibly retinal ganglion cell death. Pressure inflation measurement test protocols are commonly used to measure deformation of the peripapillary sclera with full-field noncontact optical methods. The purpose of this work was to develop and validate a new sequential 3D digital image correlation (S-DIC) approach for quantification of posterior scleral pressure induced deformation that improves z (in-depth) resolution of the DIC measurement without losing in-plane sensitivity, while also being able to contour and map deformations of the complex-shaped ONH. Our approach combines two orthogonal axes of parallax with standard 3D DIC methods using a single high-resolution camera. The enhanced capabilities of S-DIC with respect to standard 3D DIC has been demonstrated by carrying out a complete benchmark for shape, deformation, and strain measurement on an object of known complex geometry. Our S-DIC method provided a reconstruction accuracy of 0.17% and an uncertainty in z-position measurement of 8 μm. The developed methodology has also been applied to a human posterior scleral shell, including the full peripapillary sclera and optic nerve. The relatively inexpensive S-DIC approach may provide new information on the biomechanical deformations of the optic nerve head and, thus, the death of retinal ganglion cells in primary open angle glaucoma.
Starting Page	021002
Ending Page	021012
Page Count	11
File Format	PDF
ISSN	01480731
e-ISSN	15288951
Journal	Journal of Biomechanical Engineering
Volume Number	136
Issue Number	2
DOI	10.1115/1.4026224
Language	English
Publisher	The American Society of Mechanical Engineers
Publisher Date	2014-02-05
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Calibration Deformation Geometry Physiology Pressure Resolution (Optics) Shapes Shells
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biomedical Engineering

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