NDLI: PACT: participant-centered clinical trial framework

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PACT: participant-centered clinical trial framework

Content Provider	ACM Digital Library
Author	Chandra, Manasi-Sheth Gore, Ross
Abstract	Our PArticipant-centered Clinical Trial (PACT) Framework is a new approach to the design and analysis of clinical trials in the behavioral, social and health sciences. The PACT Framework is based on the idea that data can be privately maintained by participants and never revealed to researchers, while still enabling statistical models to be fit and scientific hypotheses tested. PACT rests on the assumption that clinical trial data should belong to, be controlled by, and remain in the possession of participants. Since data have value, individuals can thus accumulate personal wealth by participating in science. The innovation of the PACT Framework is that statistical models are fit by sending an objective function and vector of parameters to each participants' personal device (e.g., smart-phone), where the likelihood of that individual's data is calculated locally. Only the likelihood value is returned to the central optimizer. The optimizer aggregates likelihood values from all participants and chooses new parameters until the model converges. The PACT Framework solves or simplifies many current problems that plague human participant clinical trials. A PACT study provides significantly greater privacy for participants; automatic management of opt-in and opt-out consent; lower cost for the researcher and funding institute; a larger base of participants; and faster determination of results. PACT facilitates the use of mobile devices that can enable many trials to be performed while participants remain in their normal living environments, thus opening new paths in the way one thinks about research methods. Furthermore, if a participant opts into many clinical trials simultaneously, all of the studies could automatically have access to individual-level longitudinal data sharing.
Starting Page	1
Ending Page	6
Page Count	6
File Format	PDF
ISBN	9781510810594
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2015-07-26
Publisher Place	San Diego
Access Restriction	Subscribed
Subject Keyword	Data privacy Statistical modeling Clinical trials
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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