NDLI: Multi-scale analysis of bone

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Multi-scale analysis of bone

Content Provider	ACM Digital Library
Author	Jasiuk, Iwona
Abstract	In this paper we review our multi-scale analysis of bone. First, we characterize the bone organ experimentally at several structural levels: the macroscale (whole bone), the mesoscale (trabecular bone represented as a porous network and cortical bone represented as collection of osteons in an interstitial bone), the microscale (single trabecula or single osteon), the sub-microscale (single lamella), and the nanoscale (apatite crystals and collagen fibrils), as shown in Fig. 1. More specifically, we study the hierarchical structure of bone using scanning electron microscopy (SEM), transmission electron microscopy (TEM), second harmonic generation (SHG) microscopy, computed tomography (CT) and micro-computed tomography (micro-CT), the composition using Fourier transform infrared micro-spectroscopy (FTIR-MS), and mechanical properties using compression and tension tests, and micro- and nanoindentation techniques. Then, we model bone theoretically at each structural level in a hierarchical way. The modeling techniques include analytical micromechanics theories and simulations involving a finite element method. We compare our theoretical results on elastic moduli and strengths at different scales with mechanical property measurements. Such experimentally-based multi-scale predictive computational model can be used to assess of bone quality, including the diagnosis of bone diseases such as osteoporosis. Secondly, it provides a more complete understanding of the complex phenomena taking place in bone during fracture.
Starting Page	1
Ending Page	5
Page Count	5
File Format	PDF
ISBN	9781510810594
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2015-07-26
Publisher Place	San Diego
Access Restriction	Subscribed
Subject Keyword	Multi-scale characterization Trabecular bone Bone Multi-scale modeling Cortical bone
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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