NDLI: Computational analysis of the human and other mammalian genomes

Please wait, while we are loading the content...

Efficient extraction of mapping rules of atoms from enzymatic reaction data

On de novo interpretation of tandem mass spectra for peptide identification

Haplotypes and informative SNP selection algorithms: don't block out information

Modeling dependencies in protein-DNA binding sites

Efficient exact value computation and applications to biosequence analysis

Towards optimally multiplexed applications of universal DNA tag systems

A comparative analysis method for detecting binding sites in coding regions

Designing seeds for similarity search in genomic DNA

Maximum likelihood on four taxa phylogenetic trees: analytic solutions

Phylogenetically and spatially conserved word pairs associated with gene expression changes in yeasts

Haplotype phase inference

An integrated probabilistic model for functional prediction of proteins

Large scale reconstruction of haplotypes from genotype data

Optimizing exact genetic linkage computations

Combinatorial synthesis on macroscopic solid support units

Finding recurrent sources in sequences

Model-based inference of haplotype block variation

Computational analysis of the human and other mammalian genomes

Accurate detection of very sparse sequence motifs

Engineering a scalable placement heuristic for DNA probe arrays

Whole-genome comparative annotation and regulatory motif discovery in multiple yeast species

Joint classifier and feature optimization for cancer diagnosis using gene expression data

Large a polynomial-time nuclear vector replacement algorithm for automated NMR resonance assignments

A complete and effective move set for simplified protein folding

Invited: Prediction of protein function

Efficient rule-based haplotyping algorithms for pedigree data

Haplotype reconstruction from SNP alignment

Gene selection criterion for discriminant microarray data analysis based on extreme value distributions

A multi-expert system for the automatic detection of protein domains from sequence information

Invited

Invited: Biology and bioinformatics of halophilism

Resolution of haplotypes and haplotype frequencies from SNP genotypes of pooled samples

Transforming men into mice: the Nadeau-Taylor chromosomal breakage model revisited

Scoring two-species local alignments to try to statistically separate neutrally evolving from selected DNA segments

Approximation of protein structure for fast similarity measures

Combining phylogenetic and hidden Markov models in biosequence analysis

Invited: low-level analyses of microarray data

Invited

Using a mixture of probabilistic decision trees for direct prediction of protein function

Modeling transcription programs: inferring binding site activity and dose-response model optimization

Invited: poetry and prose of the sequences

Physical network models and multi-source data integration

Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals

Dynamic programming algorithms for haplotype block partitioning: applications to human chromosome 21 haplotype data

Computational analysis of the human and other mammalian genomes

Content Provider	ACM Digital Library
Author	Haussler, David
Abstract	Working drafts are now available for the human, mouse and rat genomes, and other mammalian genome sequences are on the way. We discuss some of the key bioinformatic analysis problems presented by this data, including the problems of assembling the sequence, finding the genes and other functional elements, and reconstructing the evolutionary history of the genomes. Recent comparisons between the human and mouse genomes have revealed that approximately 5% of the human genome appears to be more conserved with the orthologous regions in mouse than can be explained assuming neutral evolution. Is this the portion of the genome under selection for specific functions? How can we use comparative genomics to further pinpoint functional elements? How accurately can we reconstruct the evolutionary history of key parts of the human genome? We briefly outline some recent work (described in more detail in Adam Siepel's talk) combining hidden Markov models, used in bioinformatics to analyse DNA from a single species, with continuous time Markov models of molecular evolution, used to reconstruct evolutionary history of several species. While still a long way from answering these questions, these methods may contribute to such investigations.
Starting Page	138
Ending Page	138
Page Count	1
File Format	PDF
ISBN	1581136358
DOI	10.1145/640075.640093
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2003-04-10
Publisher Place	New York
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Massive turnover of functional sequence in human and other mammalian genomes.

Evolutionary analysis of mammalian genomes and associations to human disease

Computing how we became human

Massive turnover of functional sequence in human and other mammalian genomes

Computational biology: toward deciphering gene regulatory information in mammalian genomes.

Computational Analysis of the Strand Bias of the Chi Sequences and Other Oligonucleotides in Bacterial Genomes

Computational Prediction of MicroRNAs Encoded in Viral and Other Genomes

Genome rearrangements in mammalian evolution: lessons from human and mouse genomes.

Genome rearrangements in mammalian evolution: lessons from human and mouse genomes (2003)

Computational analysis of the human and other mammalian genomes

Similar Documents

Massive turnover of functional sequence in human and other mammalian genomes.

Evolutionary analysis of mammalian genomes and associations to human disease

Computing how we became human

Massive turnover of functional sequence in human and other mammalian genomes

Computational biology: toward deciphering gene regulatory information in mammalian genomes.

Computational Analysis of the Strand Bias of the Chi Sequences and Other Oligonucleotides in Bacterial Genomes

Computational Prediction of MicroRNAs Encoded in Viral and Other Genomes

Genome rearrangements in mammalian evolution: lessons from human and mouse genomes.

Genome rearrangements in mammalian evolution: lessons from human and mouse genomes (2003)

Computational analysis of the human and other mammalian genomes