NDLI: CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node.

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CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node.

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CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koseki, Haruhiko Itoh, Yasushi Ogasawara, Kazumasa Takai, Yoshimi Saito, Takashi Yokosuka, Tadashi Yamasaki, Sho Takumi, Akiko Miyoshi, Jun Ishihara, Chitose Takeuchi, Arata Arase, Noriko
Description	Country affiliation: Japan Author Affiliation: Takeuchi A ( Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.)
Abstract	In vivo immune response is triggered in the lymph node, where lymphocytes for entry into, retention at, and migration to effector sites are dynamically regulated. The molecular mechanism underlying retention regulation is the key to elucidating in vivo regulation of immune response. In this study, we describe the function of the adhesion molecule class I-restricted T cell-associated molecule (CRTAM) in regulating CD8+ T cell retention within the lymph node and eventually effector function. We previously identified CRTAM as a receptor predominantly expressed on activated CD8+ T cells, and nectin-like molecule-2 (Necl2) as its ligand. In vivo function of CRTAM-Necl2 interaction was analyzed by generating CRTAM(-/-) mice. CRTAM(-/-) mice exhibited reduced protective immunity against viral infection and impaired autoimmune diabetes induction in vivo. Although Ag-specific CRTAM(-/-) CD8+ T cells showed normal CTL functions in vitro, their number in the draining lymph node was reduced. Because CRTAM+ T cells bound efficiently to Necl2-expressing CD8+ dendritic cells (DCs) that reside in T cell area of lymph node, CRTAM may induce retention by binding to CD8+ DCs at the late stage of activation before proliferation. The CRTAM-mediated late interaction with DCs induced retention of activated CD8+ T cells in an Ag-independent fashion, and this possibly resulted in effective CTL development in the draining lymph node.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	7
Volume Number	183
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2009-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Cytology Immunology Cell Migration Inhibition Immunoglobulins Physiology Lymph Nodes Lymphocyte Activation Animals Pathology Genetics Cell Proliferation Cytotoxicity, Immunologic Epitopes, T-lymphocyte Biosynthesis Deficiency Lymphocyte Depletion Mice Mice, Inbred C57bl Mice, Inbred Icr Mice, Knockout Mice, Transgenic Time Factors Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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