NDLI: Limited role for lymphotoxin in the host immune response to Mycobacterium tuberculosis.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 185 Issue: 12

Year: 2010 Volume: 185 Issue: 11

Year: 2010 Volume: 185 Issue: 10

Year: 2010 Volume: 185 Issue: 9

Year: 2010 Volume: 185 Issue: 8

Year: 2010 Volume: 185 Issue: 7

Adenosine receptor A1 regulates polymorphonuclear cell trafficking and microvascular permeability in lipopolysaccharide-induced lung injury.

Unique requirements for reactivation of virus-specific memory B lymphocytes.

Late B cell depletion with a human anti-human CD20 IgG1κ monoclonal antibody halts the development of experimental autoimmune encephalomyelitis in marmosets.

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.

Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice.

Th17 cells contribute to viral replication in coxsackievirus B3-induced acute viral myocarditis.

Immunomodulation of delayed-type hypersensitivity responses by mesenchymal stem cells is associated with bystander T cell apoptosis in the draining lymph node.

A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation.

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes.

T cell-induced mast cell activation: a role for microparticles released from activated T cells.

The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.

Lack of TNFR p55 results in heightened expression of IFN-Î³ and IL-17 during the development of reactive arthritis.

p300-mediated acetylation stabilizes the Th-inducing POK factor.

An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.

Inhibition of hepatitis C virus replication by IFN-mediated ISGylation of HCV-NS5A.

A Notch ligand, Delta-like 1 functions as an adhesion molecule for mast cells.

B7h triggering inhibits umbilical vascular endothelial cell adhesiveness to tumor cell lines and polymorphonuclear cells.

Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis.

Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form.

IL-27/IFN-Î³ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages.

Identification of two IgD+ B cell populations in channel catfish, Ictalurus punctatus.

Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.

Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.

Human decidual tissue contains differentiated CD8+ effector-memory T cells with unique properties.

The agonists of formyl peptide receptors prevent development of severe sepsis after microbial infection.

NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells.

Limited role for lymphotoxin in the host immune response to Mycobacterium tuberculosis.

A protein's conformational stability is an immunologically dominant factor: evidence that free-energy barriers for protein unfolding limit the immunogenicity of foreign proteins.

Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization.

Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN- production in a receptor for advanced glycation end product-dependent manner.

Pandemic H1N1 influenza A viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies.

HIV-1 Nef disrupts maturation of CD4+ T cells through CD4/Lck modulation.

The origin and maturity of dendritic cells determine the pattern of sphingosine 1-phosphate receptors expressed and required for efficient migration.

Vitamin D3 upregulated protein 1 suppresses TNF- -induced NF-κB activation in hepatocarcinogenesis.

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction.

Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps.

Shedding of large functionally active CD11/CD18 Integrin complexes from leukocyte membranes during synovial inflammation distinguishes three types of arthritis through differential epitope exposure.

Prolactin-induced production of reactive oxygen species and IL-1ß in leukocytes from the bony fish gilthead seabream involves Jak/Stat and NF-κB signaling pathways.

Cell surface heparan sulfate proteoglycans influence MHC class II-restricted antigen presentation.

Context-dependent regulation of hematopoietic lineage choice by HEBAlt.

Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.

IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.

GATA2 and Sp1 positively regulate the c-kit promoter in mast cells.

Staying alive: T cell costimulation, CD28, and Bcl-xL.

Year: 2010 Volume: 185 Issue: 6

Year: 2010 Volume: 185 Issue: 5

Year: 2010 Volume: 185 Issue: 4

Year: 2010 Volume: 185 Issue: 3

Year: 2010 Volume: 185 Issue: 2

Year: 2010 Volume: 185 Issue: 1

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Limited role for lymphotoxin in the host immune response to Mycobacterium tuberculosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Olleros, Maria L. Ryffel, Bernhard Keeton, Roanne Vacher, Rachel Jacobs, Muazzam Nedospasov, Sergei A. Vasseur, Virginie Drutskaya, Marina S. Garcia, Irene Fick, Lizette Guler, Reto Allie, Nasiema Abel, Brian Court, Nathalie Quesniaux, Valerie F. J.
Description	Country affiliation: South Africa Author Affiliation: Allie N ( Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.)
Abstract	The contribution of lymphotoxin (LT) in the host immune response to virulent Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin infections was investigated. Despite their ability to induce Th1 cytokine, IFN-Î³, and IL-12 pulmonary response, 'conventional' LT (-/-) mice succumb rapidly to virulent M. tuberculosis aerosol infection, with uncontrolled bacilli growth, defective granuloma formation, necrosis, and reduced pulmonary inducible NO synthase expression, similar to TNF(-/-) mice. Contributions from developmental lymphoid abnormalities in LT (-/-) mice were excluded because hematopoietic reconstitution with conventional LT (-/-) bone marrow conferred enhanced susceptibility to wild-type mice, comparable to conventional LT (-/-) control mice. However, conventional LT (-/-) mice produced reduced levels of TNF after M. bovis bacillus Calmette-Guérin infection, and their lack of control of mycobacterial infection could be due to a defective contribution of either LT or TNF, or both, to the host immune response. To address this point, the response of 'neo-free' LT (-/-) mice with unperturbed intrinsic TNF expression to M. tuberculosis infection was investigated in a direct comparative study with conventional LT (-/-) mice. Strikingly, although conventional LT (-/-) mice were highly sensitive, similar to TNF(-/-) mice, neo-free LT (-/-) mice controlled acute M. tuberculosis infection essentially as wild-type mice. Pulmonary bacterial burden and inflammation was, however, slightly increased in neo-free LT (-/-) mice 4-5 mo postinfection, but importantly, they did not succumb to infection. Our findings revise the notion that LT might have a critical role in host defense to acute mycobacterial infection, independent of TNF, but suggest a contribution of LT in the control of chronic M. tuberculosis infection.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	7
Volume Number	185
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2010-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Lymphotoxin-alpha Immunology Tuberculosis Animals Cytokines Biosynthesis Enzyme-linked Immunosorbent Assay Metabolism Mice Mice, Inbred C57bl Mice, Knockout Mycobacterium Bovis Mycobacterium Tuberculosis Nitric Oxide Synthase Type Ii Tumor Necrosis Factor-alpha Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in