NDLI: Hapivirins and Diprovirins: Novel θ-Defensin Analogs With Potent Activity Against Influenza A $Virus^{}$

Please wait, while we are loading the content...

A novel NKR-P1B(bright) NK cell subset expresses an activated CD25(+)CX(3)CR1(+)CD62L(-)CD11b(-)CD27(-) phenotype and is prevalent in blood, liver, and gut-associated lymphoid organs of rats.

Tyrosine phosphorylation-independent regulation of lipopolysaccharide-mediated response by the transmembrane adaptor protein LAB.

Removal of syndecan-1 promotes TRAIL-induced apoptosis in myeloma cells.

Recognition and prevention of tumor metastasis by the NK receptor NKp46/NCR1.

Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats.

TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages.

TREM2 and ß-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis.

Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.

Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.

Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP.

Selective dependence of H2-M3-restricted CD8 responses on IL-15.

The adaptor protein SLP-76 regulates HIV-1 release and cell-to-cell transmission in T cells.

E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages.

Cutting edge: the 'death' adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.

Analysis of NLRP3 in the development of allergic airway disease in mice.

The impact of a large and frequent deletion in the human TCR ß locus on antiviral immunity.

Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells.

Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis.

A new hypersensitive site, HS10, and the enhancers E3′ and Ed, differentially regulate Igκ gene expression

Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells.

Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.

A TRIF-independent branch of TLR3 signaling.

Targeting TNF- to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy.

Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness.

Cutting edge: the role of IFN- receptor and MyD88 signaling in induction of IL-15 expression in vivo.

Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire.

JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression.

Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms.

Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection.

Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice.

The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma.

Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin.

Modulation of antigen presentation and B cell receptor signaling in B cells of beige mice.

The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis.

Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection.

IκB kinase ß is required for activation of NF-κB and AP-1 in CD3/CD28-stimulated primary CD4(+) T cells.

Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.

Adiponectin induces dendritic cell activation via PLCÎ³/JNK/NF-κB pathways, leading to Th1 and Th17 polarization.

Suppression of the NF-κB pathway by diesel exhaust particles impairs human antimycobacterial immunity.

Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18.

Hapivirins and Diprovirins: Novel θ-Defensin Analogs With Potent Activity Against Influenza A $Virus^{}$

Maximal adjuvant activity of nasally delivered IL-1 requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.

Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.

Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution.

MHC class II tetramers.

Year: 2012 Volume: 188 Issue: 5

Year: 2012 Volume: 188 Issue: 4

Year: 2012 Volume: 188 Issue: 3

Year: 2012 Volume: 188 Issue: 2

Year: 2012 Volume: 188 Issue: 1

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Hapivirins and Diprovirins: Novel θ-Defensin Analogs With Potent Activity Against Influenza A $Virus^{}$

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ruchala, Piotr Hartshorn, Kevan L. Verma, Anamika Gantz, Donald Tecle, Tesfaldet Doss, Mona Micewicz, Ewa D. Crouch, Erika C. Hartshorn, Alex Luong, Hai Lehrer, Robert I.
Description	Country affiliation: United States Author Affiliation: Doss M ( Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.)
Abstract	Î¸-Defensins are cyclic octadecapeptides found in nonhuman primates whose broad antiviral spectrum includes HIV-1, HSV-1, severe acute respiratory syndrome coronavirus, and influenza A virus (IAV). We previously reported that synthetic Î¸-defensins called retrocyclins can neutralize and aggregate various strains of IAV and increase IAV uptake by neutrophils. This study describes two families of peptides, hapivirins and diprovirins, whose design was inspired by retrocyclins. The goal was to develop smaller partially cyclic peptides that retain the antiviral activity of retrocyclins, while being easier to synthesize. The novel peptides also allowed for systemic substitution of key residues to evaluate the role of charge or hydrophobicity on antiviral activity. Seventy-two hapivirin or diprovirin peptides are described in this work, including several whose anti-IAV activity equals or exceeds that of normal - or Î¸-defensins. Some of these also had strong antibacterial and antifungal activity. These new peptides were active against H3N2 and H1N1 strains of IAV. Structural features imparting strong antiviral activity were identified through iterative cycles of synthesis and testing. Our findings show the importance of hydrophobic residues for antiviral activity and show that pegylation, which often increases a peptide's serum t(1/2) in vivo, can increase the antiviral activity of DpVs. The new peptides acted at an early phase of viral infection, and, when combined with pulmonary surfactant protein D, their antiviral effects were additive. The peptides strongly increased neutrophil and macrophage uptake of IAV, while inhibiting monocyte cytokine generation. Development of modified Î¸-defensin analogs provides an approach for creating novel antiviral agents for IAV infections.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1101335
Journal	The Journal of Immunology
Issue Number	6
Volume Number	188
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-03-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antiviral Agents Chemical Synthesis Pharmacology Defensins Immunology Influenza A Virus Amino Acid Sequence Animals Cell Line Chemistry Techniques, Synthetic Chromatography, High Pressure Liquid Microscopy, Electron, Transmission Molecular Sequence Data Monocytes Virology Neutrophils Peptides Structure-activity Relationship Tumor Necrosis Factor-alpha Biosynthesis Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hapivirins and Diprovirins: Novel θ-Defensin Analogs With Potent Activity Against Influenza A Virus a

θ-Defensins: Cyclic Peptides with Endless Potential

Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.

Antiviral activity of human beta-defensin 3 against vaccinia virus.

Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics

Cyclic and Acyclic Defensins Inhibit Human Immunodeficiency Virus Type-1 Replication by Different Mechanisms

Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients.

Macrophage- and neutrophil-derived TNF- instructs skin langerhans cells to prime antiviral immune responses.

The Cyclic Cystine Ladder in θ-Defensins Is Important for Structure and Stability, but Not Antibacterial Activity

Hapivirins and Diprovirins: Novel θ-Defensin Analogs With Potent Activity Against Influenza A $Virus^{}$

Similar Documents

Hapivirins and Diprovirins: Novel θ-Defensin Analogs With Potent Activity Against Influenza A Virus a

θ-Defensins: Cyclic Peptides with Endless Potential

Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.

Antiviral activity of human beta-defensin 3 against vaccinia virus.

Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics

Cyclic and Acyclic Defensins Inhibit Human Immunodeficiency Virus Type-1 Replication by Different Mechanisms

Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients.

Macrophage- and neutrophil-derived TNF- instructs skin langerhans cells to prime antiviral immune responses.

The Cyclic Cystine Ladder in θ-Defensins Is Important for Structure and Stability, but Not Antibacterial Activity

Hapivirins and Diprovirins: Novel θ-Defensin Analogs With Potent Activity Against Influenza A $Virus^{}$