NDLI: Leukemia inhibitory factor signaling is required for lung protection during pneumonia.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2012 Volume: 188 Issue: 12

The skin, a novel niche for recirculating B cells.

Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigens.

The transcription factor Zeb2 regulates signaling in mast cells.

Lipopolysaccharide-activated dendritic cells: 'exhausted' or alert and waiting?

BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.

The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.

IL-17 and TNF- sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation.

NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis.

Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis.

Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis.

High DGK- and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention.

Identification of TLT2 as an engulfment receptor for apoptotic cells.

MAPK regulation of IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-ß1 and IL-13 in human airway fibroblasts.

The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.

Amino-terminal extended peptide single-chain trimers are potent synthetic agonists for memory human CD8+ T cells.

Activated T cell exosomes promote tumor invasion via Fas signaling pathway.

Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury.

Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.

Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A.

Decoy receptor 3 suppresses TLR2-mediated B cell activation by targeting NF-κB.

Leukemia inhibitory factor signaling is required for lung protection during pneumonia.

Kv1.3 deletion biases T cells towards an immuno-regulatory phenotype and renders mice resistant to autoimmune $encephalomyelitis^{}$

HIV-1 capture and antigen presentation by dendritic cells: enhanced viral capture does not correlate with better T cell activation.

IL-15-dependent upregulation of GITR on CD8 memory phenotype T cells in the bone marrow relative to spleen and lymph node suggests the bone marrow as a site of superior bioavailability of IL-15.

EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.

Contact-dependent interference with invariant NKT cell activation by herpes simplex virus-infected cells.

IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.

L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes.

CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis.

Protein kinase C-Î¸ promotes Th17 differentiation via upregulation of Stat3.

15 kDa granulysin causes differentiation of monocytes to dendritic cells but lacks cytotoxic activity.

Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates.

A switch in pathogenic mechanism in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in IFN-Î³-inducible lysosomal thiol reductase-free mice.

Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.

Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells.

Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity.

Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-Î³ and GM-CSF.

Differential regulation of the Let-7 family of microRNAs in CD4+ T cells alters IL-10 expression.

Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.

Herpes simplex virus type 2 infection of human epithelial cells induces CXCL9 expression and CD4+ T cell migration via activation of p38-CCAAT/enhancer-binding protein-ß pathway.

Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L.

Humoral and cellular capsid-specific immune responses to adeno-associated virus type 1 in randomized healthy donors.

An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis.

Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes.

RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.

Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen.

B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation.

Immunological disruption of antiangiogenic signals by recruited allospecific T cells leads to corneal allograft rejection.

Augmented IL-15R expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.

CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential.

HLA-B27 Homodimers and Free H Chains Are Stronger Ligands for Leukocyte Ig-like Receptor B2 than Classical HLA Class 1

Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages.

A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion.

Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma.

CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity.

Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.

Cutting edge: Evidence for a dynamically driven T cell signaling mechanism.

Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.

Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rÎ³KO mice.

Loss of TNF signaling facilitates the development of a novel Ly-6C(low) macrophage population permissive for Leishmania major infection.

Human CCR4+ CCR6+ Th17 cells suppress autologous CD8+ T cell responses.

Dimerization of NKp46 receptor is essential for NKp46-mediated lysis: characterization of the dimerization site by epitope mapping.

Adjuvant-like effect of vaccinia virus 14K protein: a case study with malaria vaccine based on the circumsporozoite protein.

Hidden memories: frontline memory T cells and early pathogen interception.

Year: 2012 Volume: 188 Issue: 11

Year: 2012 Volume: 188 Issue: 10

Year: 2012 Volume: 188 Issue: 9

Year: 2012 Volume: 188 Issue: 8

Year: 2012 Volume: 188 Issue: 7

Year: 2012 Volume: 188 Issue: 6

Year: 2012 Volume: 188 Issue: 5

Year: 2012 Volume: 188 Issue: 4

Year: 2012 Volume: 188 Issue: 3

Year: 2012 Volume: 188 Issue: 2

Year: 2012 Volume: 188 Issue: 1

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Leukemia inhibitory factor signaling is required for lung protection during pneumonia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Quinton, Lee J. Kwon, Candice Y. Mizgerd, Joseph P. Hilliard, Kristie L. Jones, Matthew R. Allen, Eri
Description	Country affiliation: United States Author Affiliation: Quinton LJ ( Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA.)
Abstract	Lung infections represent a tremendous disease burden and a leading cause of acute lung injury. STAT3 signaling is essential for controlling lung injury during pneumonia. We previously identified LIF as a prominent STAT3-activating cytokine expressed in the airspaces of pneumonic lungs, but its physiological significance in this setting has never been explored. To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the presence of neutralizing anti-LIF IgG or control IgG. Anti-LIF completely eliminated lung LIF detection and markedly exacerbated lung injury compared with control mice as evidenced by airspace albumin content, lung liquid accumulation, and histological analysis. Although lung bacteriology was equivalent between groups, bacteremia was more prevalent with anti-LIF treatment, suggestive of compromised barrier function rather than impaired antibacterial defense as the cause of dissemination. Inflammatory cytokine expression was also exaggerated in anti-LIF-treated lungs, albeit after injury had ensued. Interestingly, alveolar neutrophil recruitment was modestly but significantly reduced compared with control mice despite elevated cytokine levels, indicating that inflammatory injury was not a consequence of excessive neutrophilic alveolitis. Lastly, the lung transcriptome was dramatically remodeled during pneumonia, but far more so following LIF neutralization, with gene changes implicating cell death and epithelial homeostasis among other processes relevant to tissue injury. From these findings, we conclude that endogenous LIF facilitates tissue protection during pneumonia. The LIF-STAT3 axis is identified in this study as a critical determinant of lung injury with clinical implications for pneumonia patients.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200256
Journal	The Journal of Immunology
Issue Number	12
Volume Number	188
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-06-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Leukemia Inhibitory Factor Metabolism Lung Pneumonia Stat3 Transcription Factor Signal Transduction Immunology Animals Bronchoalveolar Lavage Fluid Chemistry Escherichia Coli Escherichia Coli Infections Microbiology Immunoblotting Immunohistochemistry Mice Mice, Inbred C57bl Oligonucleotide Array Sequence Analysis Pathology Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in