NDLI: Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.

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Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reynolds, Joseph M. Wang, Yi-Hong Martinez, Gustavo J. Chang, Seon Hee Nallaparaju, Kalyan C. Dong, Chen
Description	Country affiliation: United States Author Affiliation: Reynolds JM ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA.)
Abstract	In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-17F, and IL-25 in the host defense against infection and in inflammatory diseases; however, the physiological function of IL-17C remains poorly understood. Using mice deficient in IL-17C, we demonstrate that this cytokine is crucial for the regulation of an acute experimental colitis elicited by dextran sulfate sodium. In this model, mice lacking IL-17C exhibited exacerbated disease that was associated with increased IL-17 expression by Î³Î´ T cells and Th17 cells. Moreover, IL-17C directly regulated the expression of the tight junction molecule occludin by colonic epithelial cells. Thus, our data suggest that IL-17C plays a critical role in maintaining mucosal barrier integrity.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1103014
Journal	The Journal of Immunology
Issue Number	9
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Colitis Immunology Pathology Inflammation Mediators Physiology Interleukin-17 Intestinal Mucosa Animals Cell Line Genetics Colon Cytology Dextran Sulfate Toxicity Disease Models, Animal Epithelium Metabolism Genetic Predisposition To Disease Biosynthesis Deficiency Mice Mice, Inbred C57bl Mice, Knockout Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.

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Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.

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Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.