NDLI: Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.

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Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.

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Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seufert, Jochen Kenzel, Sybille Farmand, Susan Triantafyllopoulou, Antigoni Kuijpers, Taco W. Von Süßkind-schwendi, Julius Mergen, Miriam Wennekamp, Julia Deshmukh, Sachin D. Haeffner, Monika Santos-Sierra, Sandra Van Den Berg, Timo K. Henneke, Philipp Fuchs, Sebastian
Description	Country affiliation: Germany Author Affiliation: Kenzel S ( Center for Pediatric and Adolescent Medicine, University of Freiburg, 79106 Freiburg, Germany.)
Abstract	Group B streptococci (GBS; Streptococcus agalactiae) are a major cause of invasive infections in newborn infants and in patients with type 2 diabetes. Both patient groups exhibit peripheral insulin resistance and alterations in polymorphonuclear leukocyte (PML) function. In this investigation, we studied the PML response repertoire to GBS with a focus on TLR signaling and the modulation of this response by insulin in mice and humans. We found that GBS-induced, MyD88-dependent chemokine formation of PML was specifically downmodulated by insulin via insulin receptor-mediated induction of PI3K. PI3K inhibited transcription of chemokine genes on the level of NF-κB activation and binding. Insulin specifically modulated the chemokine response of PML to whole bacteria, but affected neither activation by purified TLR agonists nor antimicrobial properties, such as migration, phagocytosis, bacterial killing, and formation of reactive oxygen species. The targeted modulation of bacteria-induced chemokine formation by insulin via PI3K may form a basis for the development of novel targets of adjunctive sepsis therapy.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	9
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Granulocytes Immunology Pathology Insulin Physiology Phosphatidylinositol 3-kinase Streptococcus Agalactiae Animals Enzymology Infant, Newborn Inflammation Microbiology Pharmacology Insulin Resistance Mice Mice, Inbred C57bl Mice, Knockout Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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