NDLI: IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2013 Volume: 190 Issue: 12

Year: 2013 Volume: 190 Issue: 11

Year: 2013 Volume: 190 Issue: 10

Year: 2013 Volume: 190 Issue: 9

Year: 2013 Volume: 190 Issue: 8

Year: 2013 Volume: 190 Issue: 7

Year: 2013 Volume: 190 Issue: 6

Year: 2013 Volume: 190 Issue: 5

Year: 2013 Volume: 190 Issue: 4

Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease.

TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.

Vκ gene repertoire and locus contraction are specified by critical DNase I hypersensitive sites within the Vκ-Jκ intervening region.

Oligodeoxynucleotides expressing polyguanosine motifs promote antitumor activity through the upregulation of IL-2.

Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase ß/NF-κB activation.

NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury.

Activation of Toll-Like Receptor 4 Is Required for the Synergistic Induction of Dual Oxidase 2 and Dual Oxidase A2 by Interferon-γ and Lipopolysaccharide in Human Pancreatic Cancer Cell $Lines^{§}$

Naturally occurring PD-1+ memory phenotype CD8 T cells belong to nonconventional CD8 T cells and are cyclophosphamide-sensitive regulatory T cells.

Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in coxsackievirus B3-infected mice.

Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3.

Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates.

STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines.

Synaptotagmin XI regulates phagocytosis and cytokine secretion in macrophages.

High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.

Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-GBM autoantibodies specific for α345NC1 hexamers

FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells.

Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.

p38 senses environmental stress to control innate immune responses via mechanistic target of rapamycin.

IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.

Self dsDNA induces IL-1β production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies

EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail.

T cells home to the thymus and control infection.

IFN- treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.

Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer.

Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin.

L chain allelic inclusion does not increase autoreactivity in lupus-prone New Zealand Black/New Zealand White mice.

Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity antibodies in the absence of neutralizing antibodies.

Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age.

Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.

An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection.

IL-23-independent induction of IL-17 from Î³Î´T cells and innate lymphoid cells promotes experimental intraocular neovascularization.

Cloning, expression, and functional characterization of TL1A-Ig.

Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production.

Mast cells recruited to mesenteric lymph nodes during helminth infection remain hypogranular and produce IL-4 and IL-6.

A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis.

GM-CSF produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa.

Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.

IL-7- and IL-15-mediated TCR sensitization enables T cell responses to self-antigens.

Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells.

A chemokine self-presentation mechanism involving formation of endothelial surface microstructures.

IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.

MiR-223 deficiency increases eosinophil progenitor proliferation.

Pathogen-triggered activation of plasmacytoid dendritic cells induces IL-10-producing B cells in response to Staphylococcus aureus.

Genome-wide analyses of amphioxus microRNAs reveal an immune regulation via miR-92d targeting C3.

Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.

A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes.

Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling.

Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage.

Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling.

Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRÎ³ deficiency.

Role of the gut microbiota in the development and function of lymphoid cells.

Year: 2013 Volume: 190 Issue: 3

Year: 2013 Volume: 190 Issue: 2

Year: 2013 Volume: 190 Issue: 1

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ding, B. Belinda Chen, Hongshan Yu, J. Jessica Bi, Enguang Ye, B. Hilda
Description	Country affiliation: United States Author Affiliation: Ding BB ( Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.)
Abstract	After undergoing Ig somatic hypermutation and Ag selection, germinal center (GC) B cells terminally differentiate into either memory or plasma cells (PCs). It is known that the CD40L and IL-21/STAT3 signaling pathways play critical roles in this process, yet it is unclear how the B cell transcription program interprets and integrates these two types of T cell-derived signals. In this study, we characterized the role of STAT3 in the GC-associated PC differentiation using purified human tonsillar GC B cells and a GC B cell-like cell line. When primary GC B cells were cultured under PC differentiation condition, STAT3 inhibition by AG490 prevented the transition from GC centrocytes to preplasmablast, suggesting that STAT3 is required for the initiation of PC development. In a GC B cell-like human B cell line, although IL-21 alone can induce low-level Blimp-1 expression, maximum Blimp-1 upregulation and optimal PC differentiation required both IL-21 and CD40L. CD40L, although having no effect on Blimp-1 as a single agent, greatly augmented the amplitude and duration of IL-21-triggered Jak-STAT3 signaling. In the human PRDM1 locus, CD40L treatment enhanced the ability of STAT3 to upregulate Blimp-1 by removing BCL6, a potent inhibitor of Blimp-1 expression, from a shared BCL6/STAT3 site in intron 3. Thus, IL-21 and CD40L collaborate through at least two distinct mechanisms to synergistically promote Blimp-1 activation and PC differentiation.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201678
Journal	The Journal of Immunology
Issue Number	4
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adjuvants, Immunologic Physiology B-lymphocyte Subsets Immunology Cd40 Ligand Cell Differentiation Interleukins Plasma Cells Repressor Proteins Biosynthesis Up-regulation Enzymology Metabolism Cell Line, Tumor Janus Kinases Molecular Sequence Data Organ Culture Techniques Palatine Tonsil Stat3 Transcription Factor Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in