NDLI: Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nayak, Jennifer L. Alam, Shabnam Sant, Andrea J.
Description	Country affiliation: United States Author Affiliation: Nayak JL ( Division of Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.)
Abstract	Influenza-specific immunity in humans is unique because there are repeated exposures to viral strains containing genetically conserved epitopes recruiting memory CD4 T cells and novel epitopes stimulating naive CD4 T cells, possibly resulting in competition between memory and naive lymphocytes. In this study, we evaluated the effect of this competition on CD4 T cell and B cell response specificity using a murine model of sequential influenza infection. We found striking and selective decreases in CD4 T cell reactivity to nonconserved hemagglutinin (HA) epitopes following secondary influenza infection. Surprisingly, this shift in CD4 T cell specificity was associated with dramatic decreases in HA-specific Ab. These results suggest that repeated exposure to influenza viruses and vaccines containing conserved internal proteins may have unintended and negative consequences on the ability to induce HA-specific Ab to novel pandemic strains of influenza. These finding could have important implications on pandemic influenza preparedness strategies.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	3
Volume Number	191
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Viral Immunology Antibody Specificity Cd4-positive T-lymphocytes Hemagglutinin Glycoproteins, Influenza Virus Orthomyxoviridae Infections Animals B-lymphocytes Epitopes, T-lymphocyte Influenza A Virus, H1n1 Subtype Influenza A Virus, H3n2 Subtype Mice Mice, Inbred C57bl Prevention & Control Virology Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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