NDLI: An overview of the intrathymic intricacies of T cell development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zúñiga-Pflücker, Juan Carlos Shah, Divya K.
Description	Country affiliation: United kingdom Author Affiliation: Shah DK ( Anthony Nolan Research Institute, Royal Free Hospital, London NW3 2QG, United Kingdom.)
Abstract	The generation of a functional and diverse repertoire of T cells occurs in the thymus from precursors arriving from the bone marrow. In this article, we introduce the various stages of mouse thymocyte development and highlight recent work using various in vivo, and, where appropriate, in vitro models of T cell development that led to discoveries in the regulation afforded by transcription factors and receptor-ligand signaling pathways in specifying, maintaining, and promoting the T cell lineage and the production of T cells. This review also discusses the role of the thymic microenvironment in providing a niche for the successful development of T cells. In particular, we focus on advances in Notch signaling and developments in Notch ligand interactions in this process.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	9
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Signal Transduction Immunology T-lymphocytes Cytology Thymus Gland Animals Cell Differentiation Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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