NDLI: Development and implementation of papillomavirus prophylactic vaccines.

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Integrin 4ß1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.

TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation.

Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1.

Multiple CD11c+ cells collaboratively express IL-1ß to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth.

Reduced regulatory T cell diversity in NOD mice is linked to early events in the thymus.

A novel mechanism underlying the basic defensive response of macrophages against Mycobacterium infection.

Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.

Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis.

1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice.

A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.

Congenital heart disease linked to maternal autoimmunity against cardiac myosin.

Synergistic therapeutic vascular cytoprotection against complement-mediated injury induced via a PKC -, AMPK-, and CREB-dependent pathway.

Conservation of pathogenic TCR homology across class II restrictions in anti-ribonucleoprotein autoimmunity: extended efficacy of T cell vaccine therapy.

Regulatory CD4+ T cells promote B cell anergy in murine lupus.

BAFF suppresses IL-15 expression in B cells.

Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.

ß7 Integrin controls mast cell recruitment, whereas E integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury.

Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug.

Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.

Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-ß production during Streptococcus pneumoniae infection.

HLA-DR 1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis.

Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells.

Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes.

Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.

Altered expression of oligodendrocyte and neuronal marker genes predicts the clinical onset of autoimmune encephalomyelitis and indicates the effectiveness of multiple sclerosis-directed therapeutics.

Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response.

Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus.

NKT cells determine titer and subtype profile of virus-specific IgG antibodies during herpes simplex virus Infection.

Heterocomplex formation between MBL/ficolin/CL-11-associated serine protease-1 and -3 and MBL/ficolin/CL-11-associated protein-1.

TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire.

Differential ability of surface and endosomal TLRs to induce CD8 T cell responses in vivo.

CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-Î³ production in response to mature dendritic cells.

Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation.

TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.

JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T Cells and Th17 cells.

High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis.

SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death.

The influenza virus-specific CTL immunodominance hierarchy in mice is determined by the relative frequency of high-avidity T cells.

CD20+ B cell depletion alters T cell homing.

Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.

Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.

NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.

Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells.

Wnt5a-Rac1-NF-κB homeostatic circuitry sustains innate immune functions in macrophages.

Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling.

Response to comment on 'killer Ig-like receptor 2DL4 does not mediate NK cell IFN-Î³ responses to soluble HLA-G preparations'.

Development and implementation of papillomavirus prophylactic vaccines.

A clue to antigen receptor tails.

An overview of the intrathymic intricacies of T cell development.

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Development and implementation of papillomavirus prophylactic vaccines.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Frazer, Ian H.
Description	Country affiliation: Australia Author Affiliation: Frazer IH ( University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Woolloongabba, Queensland 4102, Australia.)
Abstract	Translation of basic scientific findings into practical patient outcomes is a significant exercise even when the goal is conceptually straightforward, as in the development of a vaccine for an infectious disease. Recognition of the association of cervical cancer with papillomavirus infection encouraged development of a vaccine to help with prevention of this very common cancer, causing over 250,000 deaths each year worldwide. To introduce a vaccine program, it was however necessary to develop a technology for making viral Ag, demonstrate that systemic immunization could provide mucosal surface protection in the genital tract, develop assays for vaccine potency, and understand enough about the epidemiology and natural history of the infection to plan effective intervention strategies. This process took â ¼25 years. The major hurdle, now that effective vaccines are available, is to ensure their deployment in the countries where they are most needed. The development and deployment of human papillomavirus vaccines demonstrate the benefits of collaborative research activity across the globe, and between academia and industry, to translate scientific discoveries into public health benefits.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	9
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Papillomavirus Infections Prevention & Control Papillomavirus Vaccines Therapeutic Use Translational Medical Research Uterine Cervical Neoplasms Virology Animals Complications Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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