NDLI: Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.

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Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.

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Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Takami, Mariko Nishimura, Michael I. Iwashima, Makio Fujimaki, Kotaro
Description	Author Affiliation: Takami M ( Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153); Fujimaki K ( Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153); Nishimura MI ( Department of Surgery, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153.); Iwashima M ( Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153)
Abstract	The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells. In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner. Our data show that calcitriol represses the expression of BATF, a transcription factor essential for Th9, via suppressing the expression of aryl hydrocarbon receptor, without an increase in IL-10. The data show a novel link between vitamin D and two key transcription factors involved in T cell differentiation.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1500344
Journal	The Journal of Immunology
Issue Number	6
Volume Number	195
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Calcitriol Pharmacology Cell Differentiation Receptors, Aryl Hydrocarbon Antagonists & Inhibitors T-lymphocytes, Helper-inducer Cytology Asthma Basic-leucine Zipper Transcription Factors Biosynthesis Genetics Drug Effects Interleukin-10 Lymphocyte Activation Rna Interference Rna, Small Interfering Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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