NDLI: Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Boscaro, M. Darby, C. H. Hu, K. Reincke, M. Freda, P. U. Findling, J. Melmed, S. Snyder, P. Atkinson, B. Biller, B. M. K. Frohman, L. A. Tabarin, A. Grossman, A. B. Glusman, J. E. Wang, Y. Ludlam, W. H. Petersenn, S. Bertherat, J.
Description	Country affiliation: Italy Author Affiliation: Boscaro M ( Division of Endocrinology, Polytechnic University of Marche, 60126 Ancona, Italy.)
Abstract	CONTEXT: There is currently no medical therapy for Cushing's disease that targets the pituitary adenoma. Availability of such a medical therapy would be a valuable therapeutic option for the management of this disorder. OBJECTIVE: Our objective was to evaluate the short-term efficacy of the novel multireceptor ligand somatostatin analog pasireotide in patients with de novo, persistent, or recurrent Cushing's disease. DESIGN: We conducted a phase II, proof-of-concept, open-label, single-arm, 15-d multicenter study. PATIENTS: Thirty-nine patients with either de novo Cushing's disease who were candidates for pituitary surgery or with persistent or recurrent Cushing's disease after surgery without having received prior pituitary irradiation. INTERVENTION: Patients self-administered sc pasireotide 600 microg twice daily for 15 d. MAIN OUTCOME MEASURE: Normalization of urinary free cortisol (UFC) levels after 15 d treatment was the main outcome measure. RESULTS: Of the 29 patients in the primary efficacy analysis, 22 (76%) showed a reduction in UFC levels, of whom five (17%) had normal UFC levels (responders), after 15 d of treatment with pasireotide. Serum cortisol levels and plasma ACTH levels were also reduced. Steady-state plasma concentrations of pasireotide were achieved within 5 d of treatment. Responders appeared to have higher pasireotide exposure than nonresponders. CONCLUSIONS: Pasireotide produced a decrease in UFC levels in 76% of patients with Cushing's disease during the treatment period of 15 d, with direct effects on ACTH release. These results suggest that pasireotide holds promise as an effective medical treatment for this disorder.
ISSN	0021972X
e-ISSN	19457197
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	1
Volume Number	94
Language	English
Publisher	Oxford University Press
Publisher Date	2009-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Oligopeptides Therapeutic Use Pituitary Acth Hypersecretion Drug Therapy Adrenocorticotropic Hormone Blood Blood Glucose Glucagon Hydrocortisone Urine Insulin Adverse Effects Pharmacokinetics Metabolism Somatostatin Analogs & Derivatives Clinical Trial, Phase Ii Multicenter Study Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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