NDLI: Effects of recombinant human growth hormone therapy in obesity in adults: a meta analysis.

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Effects of recombinant human growth hormone therapy in obesity in adults: a meta analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mekala, Kavya C. Tritos, Nicholas A.
Description	Country affiliation: United States Author Affiliation: Mekala KC ( Division of Internal Medicine, Lahey Clinic Medical Center, Burlington, Massachusetts 01805, USA.)
Abstract	OBJECTIVE: To conduct a metaanalysis of human studies examining the efficacy and safety of recombinant human GH (rhGH) as therapy for obesity in adults. DESIGN: A thorough search of the literature (including MEDLINE, EMBASE, and the Cochrane Register) was performed for pertinent studies, which were analyzed and subsequently synthesized in a comprehensive metaanalysis. RESULTS: Administration of rhGH led to significant changes in body composition [weighted mean difference (95% confidence interval)], including fat mass [-0.9 kg (-1.3 to -0.4)], percent body fat [-1% (-1.3 to -0.7)], lean body mass [1.8 kg (0.6-2.9)], visceral adipose area [-22.8 cm(2) (-39.8 to -5.7)], and lipid profile, including total cholesterol [-7 mg/dl (-11 to -3)] and low-density lipoprotein-cholesterol [-9 mg/dl (-13 to -5)]. There were increases in fasting plasma glucose [3 mg/dl (1-6)] and insulin [1.9 muU/ml (0.2-3.7)]. The latter finding was found only in shorter-term studies. Adverse effects included [odds ratio (95% confidence interval)] arthralgias [6 (1.9-18.6)], peripheral edema [5 (2.4-10.5)], and paresthesias [6.5 (1.5-27.3)]. CONCLUSIONS: Our metaanalysis suggests that rhGH therapy leads to decrease in visceral adiposity and increase in lean body mass as well as beneficial changes in lipid profile in obese adults, without inducing weight loss. Administration of rhGH was associated with increases in fasting plasma glucose and insulinemia. Because the rhGH doses used in many studies were supraphysiological, future studies of longer duration, using carefully titrated rhGH protocols, will be needed to fully establish the effects of rhGH therapy in obesity, including effects on cardiovascular morbidity and mortality.
ISSN	0021972X
e-ISSN	19457197
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	1
Volume Number	94
Language	English
Publisher	Oxford University Press
Publisher Date	2009-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Human Growth Hormone Therapeutic Use Obesity Drug Therapy Body Composition Drug Effects Body Mass Index Endpoint Determination Adverse Effects Insulin Blood Insulin-like Growth Factor I Metabolism Meta-analysis Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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