NDLI: Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

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Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yu, Jeesuk Miao, Dongmei Eisenbarth, George S. Babu, Sunanda Steck, Andrea K. Yu, Liping Hutton, John McFann, Kim Klingensmith, Georgeanna
Description	Country affiliation: United States Author Affiliation: Yu J ( University of Colorado Health Sciences Center, Aurora, Colorado, USA. jeesuk_yu@yahoo.com)
Abstract	CONTEXT: There is controversy as to whether type 2 diabetes genetic susceptibility contributes to type 1 diabetes, and it is not known what proportion of islet autoantibody-negative new onset subjects have type 2 diabetes risk alleles. OBJECTIVES: We designed this study to evaluate whether two type 2 diabetes-associated single nucleotide polymorphisms (SNPs) of transcription factor 7-like 2 (TCF7L2) gene are associated with the development of islet autoantibody-negative diabetes vs. islet autoantibody-positive diabetes in young patients and whether these SNPs are associated with specific clinical phenotypes. DESIGN: Autoantibody against glutamic acid decarboxylase 65, islet cell antibody 512bdc (form of IA-2), insulin, ZnT8 transporter, and cytoplasmic islet cell antibody were assayed in patients with new onset diabetes seen at the Barbara Davis Center using sera obtained within 2 wk of diagnosis. We genotyped two noncoding variants in the TCF7L2 gene, rs12255372 and rs7903146, in diabetic subjects and normal controls. RESULTS: A total of 140 patients (15.7%) were negative for all islet autoantibodies among 893 subjects less than age 25 at the onset of diabetes. The allele and genotype frequencies of two SNPs showed that these are associated (odds ratio up to 4) with the development of diabetes in the autoantibody-negative diabetic cohort, but not in the autoantibody-positive diabetic cohort. CONCLUSION: TCF7L2 type 2 diabetes susceptibility alleles are associated with islet autoantibody-negative but not autoantibody-positive new onset diabetes in young patients.
ISSN	0021972X
e-ISSN	19457197
DOI	10.1210/jc.2007-2694
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	2
Volume Number	94
Language	English
Publisher	Oxford University Press
Publisher Date	2009-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diabetes Mellitus, Type 2 Genetics Polymorphism, Single Nucleotide Tcf Transcription Factors Adolescent Age Of Onset Autoantibodies Blood Case-control Studies Child, Preschool Epidemiology Immunology Gene Frequency Genetic Linkage Genetic Predisposition To Disease Infant Islets Of Langerhans Transcription Factor 7-like 2 Protein Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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Single Nucleotide Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphisms in Antiislet Autoantibody-Negative Patients at Onset of Diabetes

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Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

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Single Nucleotide Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphisms in Antiislet Autoantibody-Negative Patients at Onset of Diabetes

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