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Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men
| Content Provider | Paperity |
|---|---|
| Author | Qi, Lu Manson, JoAnn E. Rob, M. Van Dam Meigs, James B. Hunter, David J. Zhang, Cuilin Hu, Frank B. |
| Abstract | Emerging evidence indicates that variation in the transcription factor 7-like 2 (TCF7L2) gene may play a role in the pathogenesis of type 2 diabetes. In a prospective, nested, case-control study (n = 3,520) within the Nurses’ Health Study (687 type 2 diabetic case and 1,051 control subjects) and the Health Professionals Follow-up Study (886 case and 896 control subjects), we examined the association of a common variant of the TCF7L2 gene (rs12255372 [T/G]) with type 2 diabetes risk among Caucasians. Frequencies of the T-allele were significantly higher among case than control subjects; each copy of the T-allele was associated with a 1.32-fold (P = 0.0002) and 1.53-fold (P < 0.0001) increased type 2 diabetes risk in women and men, respectively. The odds ratios (95% CI) associated with homozygous carriers of the T-allele were 1.86 (1.30–2.67) and 2.15 (1.48–3.13) in women and men, respectively. Population-attributable risks for diabetes associated with the T-allele were 14.8 and 22.3% for women and men, respectively. In a meta-analysis of 3,347 case and 3,947 control sujects, each copy of the T-allele was associated with a 1.48-fold increased risk (P < 10−16). Our findings confirm that the TCF7L2 gene represents an important locus for predicting inherited susceptibility to type 2 diabetes. |
| Starting Page | 2645 |
| Ending Page | 2648 |
| File Format | HTM / HTML |
| ISSN | 00121797 |
| DOI | 10.2337/db06-0643 |
| Issue Number | 9 |
| Journal | Diabetes |
| Volume Number | 55 |
| e-ISSN | 1939327X |
| Language | English |
| Publisher | American Diabetes Association |
| Publisher Date | 2006-09-01 |
| Access Restriction | Open |
| Subject Keyword | Glp-1, glucagon-like peptide 1 Ld, linkage disequilibrium Nhs, nurses’ health study Snp, single nucleotide polymorphism Hpfs, health professionals follow-up study Tcf-4, transcription factor 4 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine |
