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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Majumder, P. P. Ghosh, S. |
| Description | Country affiliation: India Author Affiliation: Ghosh S ( Anthropology and Human Genetics Unit, Indian Statistical Institute, Calcutta, 700 035, India.) |
| Abstract | Genomewide scans for mapping loci have proved to be extremely powerful and popular. We present a semiparametric method of mapping a quantitative-trait locus (QTL) or QTLs with the use of sib-pair data generated from a two-stage genomic scan. In a two-stage genomic scan, either the entire genome or a large portion of the genome is saturated with low-density markers at the first stage. At the second stage, the intervals that are identified as probable locations of the trait loci, by means of analysis of data from the first stage, are then saturated with higher-density markers. These data are then analyzed for fine mapping of the loci. Our statistical strategy for analysis of data from the first stage is a low-stringency method based on the rank correlation of squared trait-difference values of the sib pairs and the estimated identity-by-descent scores at the marker loci. We suggest the use of a low-stringency method at the first stage, to save on computational time and to avoid missing any marker interval that may contain the trait loci. For analysis of data from the second stage, we have developed a high-stringency nonparametric-regression approach, using the kernel-smoothing technique. Through extensive simulations, we show that this approach is more powerful than is a currently used method for mapping QTLs by use of sib pairs, particularly in the presence of dominance and epistatic effects at the trait loci. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 3 |
| Volume Number | 66 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 2000-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromosome Mapping Genetic Testing Genome, Human Nuclear Family Quantitative Trait, Heritable Alleles Statistics & Numerical Data Computer Simulation Epistasis, Genetic Gene Frequency Genetics Genes, Dominant Genetic Markers Genotype Linear Models Matched-pair Analysis Models, Genetic Monte Carlo Method Recombination, Genetic Sample Size Sensitivity And Specificity Statistics, Nonparametric Comparative Study Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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