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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Francks, Clyde MacPhie, I. Laurence Richardson, Alex J. Monaco, Anthony P. Marlow, Angela J. Stein, John F. Fisher, Simon E. |
| Description | Country affiliation: United kingdom Author Affiliation: Francks C ( Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.) |
| Abstract | Genomewide quantitative-trait locus (QTL) linkage analysis was performed using a continuous measure of relative hand skill (PegQ) in a sample of 195 reading-disabled sibling pairs from the United Kingdom. This was the first genomewide screen for any measure related to handedness. The mean PegQ in the sample was equivalent to that of normative data, and PegQ was not correlated with tests of reading ability (correlations between minus sign0.13 and 0.05). Relative hand skill could therefore be considered normal within the sample. A QTL on chromosome 2p11.2-12 yielded strong evidence for linkage to PegQ (empirical P=.00007), and another suggestive QTL on 17p11-q23 was also identified (empirical P=.002). The 2p11.2-12 locus was further analyzed in an independent sample of 143 reading-disabled sibling pairs, and this analysis yielded an empirical P=.13. Relative hand skill therefore is probably a complex multifactorial phenotype with a heterogeneous background, but nevertheless is amenable to QTL-based gene-mapping approaches. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 3 |
| Volume Number | 70 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 2002-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromosome Mapping Functional Laterality Genetics Quantitative Trait, Heritable Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 2 Dyslexia Genetic Heterogeneity Genetic Testing Genome, Human Physiology Heterozygote Matched-pair Analysis Nuclear Family Phenotype Research Support, Non-u.s. Gov't Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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