NDLI: Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

Content Provider	PubMed Central
Author	Skibola, Christine F. Berndt, Sonja I. Joseph, Vijai Conde, Lucia Wang, Zhaoming Yeager, Meredith Bakker, Paul I. W. De Birmann, Brenda M. Vajdic, Claire M. Foo, Jia-nee Bracci, Paige M. Vermeulen, Roel C. H. Slager, Susan L. Sanjose, Silvia De Wang, Sophia S. Linet, Martha S. Salles, Gilles Lan, Qing Severi, Gianluca Hjalgrim, Henrik Lightfoot, Tracy Melbye, Mads Gu, Jian Hervé, Ghesquières Link, Brian K. Morton, Lindsay M. Holly, Elizabeth A. Smith, Alex Tinker, Lesley F. Teras, Lauren R. Anne, Kricker Becker, Nikolaus Purdue, Mark P. Spinelli, John J. Zhang, Yawei Giles, Graham G. Paolo, Vineis Alain, Monnereau Bertrand, Kimberly A. Demetrius, Albanes Anne, Zeleniuch-jacquotte Attilio, Gabbas Chung, Charles C. Burdett, Laurie Hutchinson, Amy Lawrence, Charles Montalvan, Rebecca Liang, Liming Huang, Jinyan Ma, Baoshan Liu, Jianjun Adami, Hans-olov Glimelius, Bengt Ye, Yuanqing Nowakowski, Grzegorz S. Dogan, Ahmet Thompson, Carrie A. Habermann, Thomas M. Novak, Anne J. Liebow, Mark Witzig, Thomas E. Weiner, George J. Schenk, Maryjean Hartge, Patricia Roos, Anneclaire J. De Cozen, Wendy Zhi, Degui Akers, Nicholas K. Jacques, Riby Smith, Martyn T. Lacher, Mortimer Villano, Danylo J. Maria, Ann Roman, Eve Kane, Eleanor Jackson, Rebecca D. North, Kari E. Diver, W. Ryan Turner, Jenny Armstrong, Bruce K. Benavente, Yolanda Boffetta, Paolo Brennan, Paul Lenka, Foretova Marc, Maynadie Staines, Anthony Mckay, James Brooks-wilson, Angela R. Zheng, Tongzhang Holford, Theodore R. Chamosa, Saioa Rudolph, Kaaks Kelly, Rachel S. Ohlsson, Bodil Travis, Ruth C. Weiderpass, Elisabete Clavel, Jacqueline Giovannucci, Edward Kraft, Peter Virtamo, Jarmo Mazza, Patrizio Cocco, Pierluigi Ennas, Maria Grazia Chiu, Brian C. H. Fraumeni, Joseph F. Nieters, Alexandra Offit, Kenneth Wu, Xifeng Cerhan, James R. Smedby, Karin E. Chanock, Stephen J. Rothman, Nathaniel
Copyright Year	2014
Abstract	Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10−20) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10−11) near ETS1; 3q28 (rs6444305, p = 1.10 × 10−10) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10−10) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10−8) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10−67 to 2.67 × 10−70). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10−16) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10−9). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
Related Links	http://dx.doi.org/10.1016/j.ajhg.2014.09.004
Ending Page	471
Page Count	10
Starting Page	462
File Format	PDF
ISSN	00029297
e-ISSN	15376605
Journal	American Journal of Human Genetics
Issue Number	4
Volume Number	95
Language	English
Publisher	Elsevier
Publisher Date	2014-10-01
Access Restriction	Open
Rights Holder	Elsevier
Subject Keyword	Genetics(clinical) Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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