NDLI: Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study.

Please wait, while we are loading the content...

Year: 2017 Volume: 48

Year: 2016 Volume: 47

Year: 2015 Volume: 46

Year: 2014 Volume: 45

Year: 2013 Volume: 44

Year: 2012 Volume: 43

Year: 2011 Volume: 42

Year: 2010 Volume: 41

Year: 2010 Volume: 41 Issue: 12

Year: 2010 Volume: 41 Issue: 11

Year: 2010 Volume: 41 Issue: 10

Year: 2010 Volume: 41 Issue: 10 Supplementary

Year: 2010 Volume: 41 Issue: 9

Year: 2010 Volume: 41 Issue: 8

Year: 2010 Volume: 41 Issue: 7

Year: 2010 Volume: 41 Issue: 6

Year: 2010 Volume: 41 Issue: 5

Year: 2010 Volume: 41 Issue: 4

Age-related macular degeneration: why should stroke physicians care?

Embolus trajectory through a physical replica of the major cerebral arteries.

Quality-adjusted life expectancy (QALE) and loss of QALE for patients with ischemic stroke and intracerebral hemorrhage: a 13-year follow-up.

Cystatin C and the risk for cardiovascular events in patients with asymptomatic carotid atherosclerosis.

Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea.

Neovascular age-related macular degeneration and the risk of stroke: a 5-year population-based follow-up study.

Reliability of measuring lesion volumes in transient ischemic attack and minor stroke.

Critical role for copper/zinc-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.

Recanalization of vertebral artery dissection.

Drip, ship, and retrieve: cooperative recanalization therapy in acute basilar artery occlusion.

Moxibustion for stroke rehabilitation: systematic review.

Safety of TCD 'bubble study'.

Differing risk factor profiles of ischemic stroke subtypes: evidence for a distinct lacunar arteriopathy?

Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden.

'Al pie de la letra': crafting a report card for elderly Spanish-only-speaking patients with stroke.

Urinary tract infections complicating stroke: mechanisms, consequences, and possible solutions.

Alarmingly high serious complication rate of stent-assisted coiling in unruptured intracranial aneurysms: the need for reflection and reconsideration.

Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia.

Outcome improvement in acute stroke revascularization procedures.

'Where there's smoke ...': are premature ventricular complexes a new risk factor for stroke?

Emergency physician and stroke specialist beliefs and expectations regarding telestroke.

A matching algorithm to address imbalances in study populations: application to the National Institute of Neurological Diseases and Stroke Recombinant Tissue Plasminogen Activator acute stroke trial.

Acupuncture in poststroke rehabilitation: a systematic review and meta-analysis of randomized trials.

Five-year outcome of a stroke cohort in Martinique, French West Indies: Etude Réalisée en Martinique et Centrée sur l'Incidence des Accidents vasculaires cérebraux, Part 2.

Statewide hospital-based stroke services in North Carolina: changes over 10 years.

Radiological investigation of spontaneous intracerebral hemorrhage: systematic review and trinational survey.

Presence of finger extension and shoulder abduction within 72 hours after stroke predicts functional recovery: early prediction of functional outcome after stroke: the EPOS cohort study.

Ultraearly thrombolysis in acute ischemic stroke is associated with better outcome and lower mortality.

Advances in genomic analysis of stroke: what have we learned and where are we headed?

Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study.

Retinal microvascular signs may provide clues to the underlying vasculopathy in patients with deep intracerebral hemorrhage.

Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals.

Premature ventricular complexes and the risk of incident stroke: the Atherosclerosis Risk In Communities (ARIC) Study.

Diagnostic criteria and yield of real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures.

ABC/XYZ estimates intracerebral hemorrhage volume as a percent of total brain volume in children.

Effect of combined aspirin and extended-release dipyridamole versus clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PRoFESS subgroup analysis.

Targeting the sphingolipid signaling pathway in stroke.

Stroke genome-wide association studies: the large numbers imperative.

Effects of hypobaric hypoxia on cerebral autoregulation.

Evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive rats.

What do white matter hyperintensities really represent?

Relative energy index of microembolic signal can predict malignant microemboli.

Familial stroke 2700 years ago.

Intracerebral hemorrhage in cocaine users.

Should decompressive surgery be performed in malignant cerebral venous thrombosis?: a series of 12 patients.

What is a minor stroke?

Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston study.

Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial.

Oxidative stress after thrombolysis-induced reperfusion in human stroke.

Comment on US geographic distribution of recombinant tissue plasminogen activator use by hospitals for acute ischemic stroke.

Systematic review and pooled analysis of published and unpublished validations of the ABCD and ABCD2 transient ischemic attack risk scores.

Differences in demographic characteristics and risk factors in patients with spontaneous vertebral artery dissections with and without ischemic events.

Iron-related brain damage in patients with intracerebral hemorrhage.

Carotid artery stenting in octogenarians: periprocedural stroke risk predictor analysis from the multicenter Carotid ACCULINK/ACCUNET Post Approval Trial to Uncover Rare Events (CAPTURE 2) clinical trial.

Racial disparities in awareness and treatment of atrial fibrillation: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.

Dose-response relation between neuromuscular electrical stimulation and upper-extremity function in patients with stroke.

Acute corticospinal tract Wallerian degeneration is associated with stroke outcome.

Year: 2010 Volume: 41 Issue: 3

Year: 2010 Volume: 41 Issue: 2

Year: 2010 Volume: 41 Issue: 1

Year: 2009 Volume: 40

Year: 2008 Volume: 39

Year: 2007 Volume: 38

Year: 2006 Volume: 37

Year: 2005 Volume: 36

Year: 2004 Volume: 35

Year: 2003 Volume: 34

Year: 2002 Volume: 33

Year: 2001 Volume: 32

Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Himali, Jayandra J. Kelly-Hayes, Margaret Au, Rhoda DeCarli, Charles Beiser, Alexa Romero, Jose R. Seshadri, Sudha Debette, Stéphanie Kase, Carlos S. Wolf, Philip A.
Description	Country affiliation: United States Author Affiliation: Debette S ( Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA. sdebette@bu.edu)
Abstract	BACKGROUND AND PURPOSE: White matter hyperintensities and MRI-defined brain infarcts (BIs) have individually been related to stroke, dementia, and mortality in population-based studies, mainly in older people. Their significance in middle-aged community-dwelling persons and the relative importance of these associations remain unclear. We simultaneously assessed the relation of white matter hyperintensities and BI with incident stroke, mild cognitive impairment, dementia, and mortality in a middle-aged community-based cohort. METHODS: A total of 2229 Framingham Offspring Study participants aged 62+/-9 years underwent volumetric brain MRI and neuropsychological testing (1999 to 2005). Incident stroke, dementia, and mortality were prospectively ascertained and for 1694 participants in whom a second neuropsychological assessment was performed (2005 to 2007), incident mild cognitive impairment was evaluated. All outcomes were related to white matter hyperintensities volume (WMHV), age-specific extensive WMHV and BI adjusting for age and gender. RESULTS: Extensive WMHV and BI were associated with an increased risk of stroke (hazard ratio [HR]=2.28, 95% CI: 1.02 to 5.13; HR=2.84, 95% CI: 1.32 to 6.10). WMHV, extensive WMHV, and BI were associated with an increased risk of dementia (HR=2.22, 95% CI: 1.32 to 3.72; HR=3.97, 95% CI: 1.10 to 14.30; HR=6.12, 95% CI: 1.82 to 20.54) independently of vascular risk factors and interim stroke. WMHV and extensive WMHV were associated with incident amnestic mild cognitive impairment in participants aged > or = 60 years only (OR=2.47, 95% CI: 1.31 to 4.66 and OR=1.49, 95% CI: 1.14 to 1.97). WMHV and extensive WMHV were associated with an increased risk of death (HR=1.38, 95% CI: 1.13 to 1.69; HR=2.27, 95% CI: 1.41 to 3.65) independent of vascular risk factors and of interim stroke and dementia. CONCLUSIONS: In a large community-based sample of middle-aged adults, BI predicted an increased risk of stroke and dementia independent of vascular risk factors. White matter hyperintensities portended an increased risk of stroke, amnestic mild cognitive impairment, dementia, and death independent of vascular risk factors and interim vascular events.
ISSN	00392499
e-ISSN	15244628
DOI	10.1161/STROKEAHA.109.570044
Journal	Stroke
Issue Number	4
Volume Number	41
Language	English
Publisher	Lippincott Williams & Wilkins (on behalf of the American Heart Association)
Publisher Date	2010-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebrovascular Trauma Cognition Disorders Magnetic Resonance Imaging Stroke Complications Mortality Pathology Etiology Physiopathology Dementia Neuropsychological Tests Prospective Studies Risk Factors Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Cardiology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical)

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in