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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Braga, Raquel Rennó Sales, Juliana Ortiz, Gisela Maria Dellamora Garcia, Sheila Marins, Rita de Cassia Elias Estrela |
| Description | Country affiliation: Brazil Author Affiliation: Braga RR ( Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, Brazil. raquel.braga@pbiotech.com) |
| Abstract | The aim of this work was to develop and validate an ultraviolet derivative spectrophotometric (UVDS) method for the quantitative determination of allantoin (ALL) in liposomes, gels and creams. Liposomes were prepared by methods of thin film hydration and mechanical agitation. Solutions of ALL in 0.1 mol/L NaOH with ethanol:water (70:30, v/v) were prepared in order to destroy liposome vesicles. Spectral interference from components of liposomes, cream, gel and ALL degradation products was eliminated using the second-order derivative of the zero-order spectrum. Characterization of ALL in 0.1 mol/L NaOH was carried out by direct infusion mass spectrometry. Absorbances of ALL solutions were measured at 266.6 nm of the second-derivative spectrum and linearity was observed in the ALL concentration range of 50-300 µgmL(-1) (correlation coefficient (r)=0.9961). The mean recovery percentage was 100.68 ± 1.61, repeatability expressed as relative standard deviation (RSD) was 1.07 and 2.12%, and intermediate precision (RSD) was 2.16%. The proposed UVDS method was found to be linear, precise, accurate, robust and selective, providing rapid and specific determination of ALL in raw materials and in topical formulations. |
| ISSN | 13861425 |
| Volume Number | 91 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Allantoin Analysis Cosmetics Chemistry Liposomes Pharmaceutical Preparations Spectrophotometry, Ultraviolet Methods Gels Linear Models Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't Validation Studies Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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