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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Arjmand, Farukh Jamsheera, A. Mohapatra, D. K. |
| Description | Country affiliation: India Author Affiliation: Arjmand F ( Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, Uttar Pradesh, India. farukh_arjmand@yahoo.co.in) |
| Abstract | New tetrapeptide complexes Cu(II)·Ala-Pro-Ala-Pro (1) and Zn(II)·Ala-Pro-Ala-Pro (2) were synthesized from the reaction of tetrapeptide, Ala-Pro-Ala-Pro and CuCl2/ZnCl2 and were thoroughly characterized by elemental analysis, IR,(1)H and (13)C NMR (in case of 2), ESI-MS, UV and molar conductance measurements. The solution stability study was carried out employing UV-vis absorption titrations over a broad range of pH which suggested the stability of the complexes in solution. In vitro interaction of complexes 1 and 2 with CT-DNA was studied employing UV-vis, fluorescence, circular dichroic and viscometry studies. To throw insight into molecular binding event at the target site, UV-vis titrations of 1 and 2 with mononucleotides of interest viz.; 5'-GMP and 5'-TMP were carried out. Cleavage activity of the complexes with pBR322 plasmid DNA was evaluated by agarose gel electrophoresis and, the electrophoresis pattern demonstrated that both the complexes 1 and 2 are efficient cleavage agents. Further, the Cu(II) complex displayed efficient oxidative cleavage of supercoiled DNA while various reactive oxygen species are responsible for the cleavage in Zn(II) complex. |
| ISSN | 13861425 |
| Volume Number | 108 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Coordination Complexes Chemical Synthesis Metabolism Copper Dna Cleavage Dna Oligopeptides Zinc Absorption Animals Cattle Circular Dichroism Chemistry Electron Spin Resonance Spectroscopy Electrons Electrophoresis, Agar Gel Kinetics Luminescence Magnetic Resonance Spectroscopy Mass Spectrometry Protein Binding Protein Stability Solutions Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Viscosity Journal Article Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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