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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mohamed, Afaf O. Zaazaa, Hala E. Hawwam, Maha A. Abdelkawy, Mohamed |
| Description | Author Affiliation: Zaazaa HE ( Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt. Electronic address: hazaza@hotmail.com.); Mohamed AO ( National Organization for Drug Control and Research (NODCAR), 6-Abu Hazem Street, Pyramids Ave., P.O. Box 29, 35521 Giza, Egypt.); Hawwam MA ( National Organization for Drug Control and Research (NODCAR), 6-Abu Hazem Street, Pyramids Ave., P.O. Box 29, 35521 Giza, Egypt.); Abdelkawy M ( Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt.) |
| Abstract | A simple, sensitive and selective spectrofluorimetric method has been developed for the determination of 3-methylflavone-8-carboxylic acid as the main active metabolite of flavoxate hydrochloride in human urine. The proposed method was based on the measurement of the native fluorescence of the metabolite in methanol at an emission wavelength 390 nm, upon excitation at 338 nm. Moreover, the urinary excretion pattern has been calculated using the proposed method. Taking the advantage that 3-methylflavone-8-carboxylic acid is also the alkaline degradate, the proposed method was applied to in vitro determination of flavoxate hydrochloride in tablets dosage form via the measurement of its corresponding degradate. The method was validated in accordance with the ICH requirements and statistically compared to the official method with no significant difference in performance. |
| ISSN | 13861425 |
| Volume Number | 134 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-05 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Flavoxate Analogs & Derivatives Pharmacokinetics Fluorometry Methods Calibration Metabolism Urine Humans Limit Of Detection Reproducibility Of Results Sensitivity And Specificity Solvents Chemistry Tablets Journal Article Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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