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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Omar, Mahmoud A. Aly, Alshymaa A. Hammad, Mohamed A. Nagy, Dalia M. |
| Description | Country affiliation: Egypt Author Affiliation: Omar MA ( Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.); Hammad MA ( Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt. Electronic address: m_abdelkhalek_eg@yahoo.com.); Nagy DM ( Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.); Aly AA ( Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt.) |
| Abstract | A simple and sensitive spectrofluorimetric method has been developed and validated for determination of amikacin sulfate, neomycin sulfate and tobramycin in pure forms, pharmaceutical formulations and human plasma. The method was based on condensation reaction of cited drugs with ninhydrin and phenylacetaldehyde in buffered medium (pH 6) resulting in formation of fluorescent products which exhibit excitation and emission maxima at 395 and 470nm, respectively. The different experimental parameters affecting the development and stability of the reaction products were carefully studied and optimized. The calibration plots were constructed with good correlation coefficients (0.9993 for tobramycin and 0.9996 for both neomycin and amikacin). The proposed method was successfully applied for the analysis of cited drugs in dosage forms with high accuracy (98.33-101.7)±(0.80-1.26)%. The results show an excellent agreement with the reference method, indicating no significant difference in accuracy and precision. Due to its high sensitivity, the proposed method was applied successfully for determination of amikacin in real human plasma. |
| ISSN | 13861425 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Volume Number | 136 Pt C |
| e-ISSN | 18733557 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-02-05 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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