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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khadeer Ahamed, Mohamed B. Abdul Majid, Amin M. S. Guan, Teoh S. Haque, Rosenani A. Hussein, Mouayed A. |
| Description | Country affiliation: Malaysia Author Affiliation: Hussein MA ( School of Chemical Science, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia.); Guan TS ( School of Chemical Science, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia. Electronic address: sgteoh@usm.my.); Haque RA ( School of Chemical Science, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia.); Khadeer Ahamed MB ( EMAN Research and Testing Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia.); Abdul Majid AM ( EMAN Research and Testing Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia.) |
| Abstract | Four dioxomolybdenum(VI) complexes were synthesized by reacting [MoO2(acac)2] with N-ethyl-2-(5-bromo-2-hydroxybenzylidene) hydrazinecarbothioamide (1), N-ethyl-2-(5-allyl-3-methoxy-2-hydroxybenzylidene) hydrazinecarbothioamide (2), N-methyl-2-(3-tert-butyl-2-hydroxybenzylidene) hydrazinecarbothioamide (3), and N-ethyl-2-(3-methyl-2-hydroxybenzylidene) hydrazinecarbothioamide (4). The molecular structures of 1, 2, and all the synthesized complexes were determined using single crystal X-ray crystallography. The binding properties of the ligand and complexes with calf thymus DNA (CT-DNA) were investigated via UV, fluorescence titrations, and viscosity measurement. Gel electrophoresis revealed that all the complexes cleave pBR 322 plasmid DNA. The cytotoxicity of the complexes were studied against the HCT 116 human colorectal cell line. All the complexes exhibited more pronounced activity than the standard reference drug 5-fluorouracil (IC50 7.3µM). These studies show that dioxomolybdenum(VI) complexes could be potentially useful in chemotherapy. |
| ISSN | 13861425 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Volume Number | 136 Pt C |
| e-ISSN | 18733557 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-02-05 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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