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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sreekanth, S. Anas, Abdulaziz Das, Ani V. Jayalekshmi, S. Sajimol Augustine, M. |
| Description | Author Affiliation: Sajimol Augustine M ( Department of Physics, St. Teresa's College, Kochi 682 011, Kerala, India. Electronic address: sajimollazar@gmail.com.); Anas A ( Council of Scientific and Industrial Research, National Institute of Oceanography, Regional Centre, Cochin 682 018, India.); Das AV ( Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.); Sreekanth S ( Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.); Jayalekshmi S ( Department of Physics, Cochin University of Science and Technology, Kochi 682 022, Kerala, India. Electronic address: jayalekshmi@cusat.ac.in.) |
| Abstract | Highly luminescent, manganese doped, zinc sulphide (ZnS:Mn) nanocrystals biofunctionalized with chitosan and various aminoacids such as L-citrulline, L-lysine, L-arginine, L-serine, L-histidine and glycine were synthesized by chemical capping co-precipitation method at room temperature, which is a simple and cost effective technique. The synthesized nanocrystals were structurally characterized by TEM, XRD, EDXS and FT-IR spectroscopy techniques. They possess high colloidal stability with strong orange red photoluminescence emission at 598 nm. The intensity of orange red emission has been observed to be maximum in L-citrulline capped ZnS:Mn nanocrystals in which the emission at 420 nm is effectively quenched by surface passivation due to capping. Taking into consideration the prospects of these highly luminescent, bio-compatible ZnS:Mn nanocrystals in bio-imaging applications, cytotoxicity studies were conducted to identify the capping combination which would accomplish minimum toxic effects. ZnS:Mn nanocrystals biofunctionalized with chitosan, L-citrulline, glycine, L-artginine, L-serine and L-histidine showed least toxicity up to 10 nM concentrations in mouse fibroblast L929 cells, which further confirms their cytocompatibility. Also the ZnS:Mn nanocrystals biofunctionalized with l-arginine showed maximum uptake in in vitro studies carried out in human embryonic kidney cells, HEK-293T, which shows the significant role of this particular amino acid in fetoplacental nutrition. The present study highlights the suitability of aminoacid conjugated ZnS:Mn nanocrystals, as promising candidates for biomedical applications. |
| ISSN | 13861425 |
| Volume Number | 136 Pt B |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-02-05 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Amino Acids Chemistry Chitosan Endocytosis Drug Effects Manganese Toxicity Nanoparticles Sulfides Zinc Compounds Animals Cell Death Cell Survival Hek293 Cells Humans Luminescence Mice Ultrastructure Spectroscopy, Fourier Transform Infrared X-ray Diffraction Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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