NDLI: Vibrational spectroscopic study of polymorphism and polymorphic transformation of the anti-viral drug lamivudine.

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Vibrational spectroscopic study of polymorphism and polymorphic transformation of the anti-viral drug lamivudine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Qi Zhang, Huili Hong, Zhi Tang, Wenjian Li, Yafang Fang, Hongxia Du, Yong Xue, Jiadan
Description	Author Affiliation: Du Y ( Centre for THz Research, China Jiliang University, Hangzhou 310018, China. Electronic address: yongdu@cjlu.edu.cn.); Zhang H ( Centre for THz Research, China Jiliang University, Hangzhou 310018, China.); Xue J ( Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.); Tang W ( School of Pharmacy, Anhui Medical University, Hefei 230032, China.); Fang H ( Centre for THz Research, China Jiliang University, Hangzhou 310018, China.); Zhang Q ( Centre for THz Research, China Jiliang University, Hangzhou 310018, China.); Li Y ( Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.); Hong Z ( Centre for THz Research, China Jiliang University, Hangzhou 310018, China.)
Abstract	Vibrational spectra of hydrated and anhydrous lamivudines, and also the dynamic process of polymorphic transformation have been characterized by Fourier transform infrared (FT-IR) and Raman spectroscopic techniques. The vibrational modes of both polymorphic lamivudines are assigned. FT-IR and Raman spectral results show that the interaction between crystalline water and lamivudine molecular has an important effect on the molecular vibration motions of polymorphic lamivudines. The two characteristic Raman peaks at 783 and 798 cm(-1) represent hydrated and anhydrous lamivudine respectively. The relationship between changes of two characteristic peak normalized areas and heating time could be fitted with single exponential functions, and the dynamic information of polymorphic transformation of lamivudine drug is obtained. The decay rate of characteristic peak for hydrated lamivudine and the growth rate of that for anhydrous lamivudine are consistent during dehydration transformation process. The reported results provide us important benchmark for qualitatively monitoring different polymorphic drugs and also establishing the corresponding model for the polymorphic transformation of drugs in related pharmaceutical research fields.
ISSN	13861425
Volume Number	137
e-ISSN	18733557
Journal	Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Language	English
Publisher	Elsevier
Publisher Date	2015-02-25
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antiviral Agents Chemistry Lamivudine Models, Molecular Quantum Theory Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Water Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation

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