NDLI: Photodynamic therapy effect of zinc monoamino phthalocyanine-folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells.

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Application of hollow cylindrical wheat stem for electromembrane extraction of thorium in water samples.

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Photodynamic therapy effect of zinc monoamino phthalocyanine-folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells.

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Photodynamic therapy effect of zinc monoamino phthalocyanine-folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ogbodu, Racheal O. Karsten, Aletta Nyokong, Tebello Ndhundhuma, Ivy
Description	Country affiliation: South Africa Author Affiliation: Ogbodu RO ( Rhodes University, Chemistry Department, Rhodes University, Grahamstown 6140, South Africa.); Ndhundhuma I ( Biophotonics, National Laser Centre, CSIR, Pretoria 0001, South Africa.); Karsten A ( Biophotonics, National Laser Centre, CSIR, Pretoria 0001, South Africa.); Nyokong T ( Rhodes University, Chemistry Department, Rhodes University, Grahamstown 6140, South Africa. Electronic address: t.nyokong@ru.ac.za.)
Abstract	This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic to the melanoma A375 cell line in the absence of light. Upon irradiation of the melanoma A375 cell line with a 676 nm diode laser at a power density of 98 mW/cm(2) at 5 J/cm(2) about 60% and 63% cell death was observed in the presence of ZnMAPc-FA and ZnMAPc-FA-SWCNT respectively. SWCNT-FA had no significant photodynamic therapy or photothermal effect to the cell, only 23% of cell death was observed after irradiation.
ISSN	13861425
Volume Number	137
e-ISSN	18733557
Journal	Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Language	English
Publisher	Elsevier
Publisher Date	2015-02-25
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Folic Acid Indoles Melanoma Drug Therapy Nanotubes, Carbon Chemistry Photochemotherapy Radiation-sensitizing Agents Vitamin B Complex Zinc Cell Line, Tumor Humans Pharmacology Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation

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