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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lin, Yang-Yang Wu, Yong Guo, Qi-Feng Zhu, Jian-Wei Liu, Si-Hong Xu, Hui-Hua Liu, Ya-Min Zhang, Gui-Qiang Cao, Di-Hua Liang, Jun-Bo Wang, Yan |
| Description | Author Affiliation: Liu SH ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Zhu JW ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Xu HH ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Wang Y ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Liu YM ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Liang JB ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Zhang GQ ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Cao DH ( Department of Pharmacy, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Lin YY ( Department of Pharmacy, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China.); Wu Y ( Department of Oncology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China. Electronic address: wuyong@gzhmu.edu.cn.); Guo QF ( Department of Orthopaedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, PR China. Electronic address: qfguo@gzhmu.edu.cn.) |
| Abstract | The cytotoxic activity of two Ru(II) complexes against A549, BEL-7402, HeLa, PC-12, SGC-7901 and SiHa cell lines was investigated by MTT method. Complexes 1 and 2 show moderate cytotoxicity toward BEL-7402 cells with an IC50 value of 53.9 ± 3.4 and 39.3 ± 2.1 µM. The effects of the complexes inducing apoptosis, cellular uptake, reactive oxygen species and mitochondrial membrane potential in BEL-7402 cells have been studied by fluorescence microscopy. The percentages of apoptotic and necrotic cells and cell cycle arrest were studied by flow cytometry. The BSA-binding behaviors were investigated by UV/visible and fluorescent spectra. |
| ISSN | 13861425 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Volume Number | 161 |
| e-ISSN | 18733557 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-05-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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