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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Oliviero, M. Rametta, G. Manzo, S. Schiavo, S. Miglietta, M. |
| Description | Author Affiliation: Schiavo S ( Enea CR Portici, P. le E. Fermi, 1, 80055 Portici, Naples, Italy. Electronic address: simonaschiavo@gmail.com.); Oliviero M ( Enea CR Portici, P. le E. Fermi, 1, 80055 Portici, Naples, Italy.); Miglietta M ( Enea CR Portici, P. le E. Fermi, 1, 80055 Portici, Naples, Italy.); Rametta G ( Enea CR Portici, P. le E. Fermi, 1, 80055 Portici, Naples, Italy.); Manzo S ( Enea CR Portici, P. le E. Fermi, 1, 80055 Portici, Naples, Italy.) |
| Abstract | The increasing use of oxide nanoparticles (NPs) in commercial products has intensified the potential release into the aquatic environment where algae represent the basis of the trophic chain. NP effects upon algae population growth were indeed already reported in literature, but the concurrent effects at cellular and genomic levels are still largely unexplored. Our work investigates the genotoxic (by COMET assay) and cytotoxic effects (by qualitative ROS production and cell viability) of ZnO nanoparticles toward marine microalgae Dunaliella tertiolecta. A comparison at defined population growth inhibition levels (i.e. 50% Effect Concentration, EC50, and No Observed Effect Concentration, NOEC) with SiO2 and TiO2 genotoxic effects and previously investigated cytotoxic effects (Manzo et al., 2015) was performed in order to elucidate the possible diverse mechanisms leading to algae growth inhibition. After 72h exposure, ZnO particles act firstly at the level of cell division inhibition (EC50: 2mg Zn/L) while the genotoxic action is evident only starting from 5mg Zn/L. This outcome could be ascribable mainly to the release of toxic ions from the aggregate of ZnO particle in the proximity of cell membrane. In the main, at EC50 and NOEC values for ZnO NPs showed the lowest cytotoxic and genotoxic effect with respect to TiO2 and SiO2. Based on Mutagenic Index (MI) the rank of toxicity is actually: TiO2>SiO2>ZnO with TiO2 and SiO2 that showed similar MI values at both NOEC and EC50 concentrations. The results presented herein suggest that up to TiO2 NOEC (7.5mg/L), the algae DNA repair mechanism is efficient and the DNA damage does not result in an evident algae population growth inhibition. A similar trend for SiO2, although at lower effect level with respect to TiO2, is observable. The comparison among all the tested nanomaterial toxicity patterns highlighted that the algae population growth inhibition occurred through pathways specific for each NP also related to their different physicochemical behaviors in seawater. |
| ISSN | 00489697 |
| Volume Number | 550 |
| e-ISSN | 18791026 |
| Journal | Science of The Total Environment |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Chlorophyta Drug Effects Metal Nanoparticles Toxicity Silicon Dioxide Titanium Water Pollutants, Chemical Zinc Oxide Growth & Development Comet Assay Mutagens Journal Article Discipline Environmental Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Waste Management and Disposal Pollution Environmental Engineering |
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