NDLI: What should the Z-score of native protein structures be?

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What should the Z-score of native protein structures be?

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What should the Z-score of native protein structures be?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, L. Skolnick, J.
Description	Country affiliation: United States Author Affiliation: Zhang L ( Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.)
Abstract	The Z-score of a protein is defined as the energy separation between the native fold and the average of an ensemble of misfolds in the units of the standard deviation of the ensemble. The Z-score is often used as a way of testing the knowledge-based potentials for their ability to recognize the native fold from other alternatives. However, it is not known what range of values the Z-scores should have if one had a correct potential. Here, we offer an estimate of Z-scores extracted from calorimetric measurements of proteins. The energies obtained from these experimental data are compared with those from computer simulations of a lattice model protein. It is suggested that the Z-scores calculated from different knowledge-based potentials are generally too small in comparison with the experimental values.
ISSN	09618368
e-ISSN	1469896X
Journal	Protein Science
Issue Number	5
Volume Number	7
Language	English
Publisher	Wiley-Blackwell (on behalf of The Protein Society)
Publisher Date	1998-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Protein Conformation Proteins Chemistry Models, Chemical Research Support, U.s. Gov't, P.h.s. Discipline Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Biochemistry

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