NDLI: Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes.

Please wait, while we are loading the content...

Identification of a novel function of Id-1 in mediating the anticancer responses of SAMC, a water-soluble garlic derivative, in human bladder cancer cells.

Multiplexed profiling of secreted proteins for the detection of potential space biomarkers.

Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells.

Erythropoietin combined with granulocyte colonystimulating factor enhances MMP-2 expression in mesenchymal stem cells and promotes cell migration.

Impaired left-ventricular cardiac function in male GPR30-deficient mice.

Effect of intratumoral injection of mutant type p27Kip1 followed by in vivo electroporation on radiotherapy-resistant human oral tongue cancer xenografts.

Down-regulation of zinc transporter 8 in the pancreas of db/db mice is rescued by Exendin-4 administration.

Reduced expression of indoleamine 2,3-dioxygenase participates in pathogenesis of preeclampsia via regulatory T cells.

Apoptin sensitizes radiation-induced cell death via classic mitochondrial, caspase and p53-dependent signaling in HepG2 cells.

Fibronectin increases RhoA activity through inhibition of PKA in the human gastric cancer cell line SGC-7901.

Distribution of Eppin in mouse and human testis.

Intracellular iodinated compounds affect sodium iodide symporter expression through TSH-mediated signaling pathways.

Proinflammatory role of protease-activated receptor-2 in intestinal ischemia/reperfusion injury in rats.

Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population.

Troglitazone induces apoptosis in gastric cancer cells through the NAG-1 pathway.

Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells.

Molecular characterization of rat cvHsp/HspB7 in vitro and its dynamic molecular architecture.

Chan-Yu-Bao-Yuan-Tang and 5-fluorouracil synergistically induce apoptosis by means of the caspase-3 signaling pathway in lung and cervical cancer cells.

Quantitative analysis of the relationship between microRNA124a, -34b and -203 gene methylation and cervical oncogenesis.

Optimization of conditions for transfection with the Sofast gene vector.

Screening for differential methylation status in fetal myocardial tissue samples with ventricular septal defects by promoter methylation microarrays.

Inhibition of endothelial cell migration through the downregulation of MMP-9 by A-kinase anchoring protein 12.

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes.

Confirmation of the biological significance of transthyretin as a biomarker for cutaneous T-cell lymphoma by its protein interaction partners.

Functional significance of B7-H1 expressed by human uveal melanoma cells.

Immunoactivative role of indoleamine 2,3dioxygenase in gastric cancer cells in vitro.

Lack of association between methylenetetrahydrofolate reductase genetic polymorphisms and postmenopausal breast cancer risk.

Association between the CCR2-Val64Ile polymorphism and susceptibility to HIV-1 infection: a meta-analysis.

Effect of hyperthermia on the apoptosis and proliferation of CaSki cells.

MAPK inhibitors differentially affect gallic acid-induced human pulmonary fibroblast cell growth inhibition.

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mohanraj, Rajesh Pacher, Pál Gao, Rachel Yue Yin, Shi Mukhopadhyay, Partha Horváth, Béla Wang, Hua
Description	Country affiliation: United States Author Affiliation: Gao RY ( Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.)
Abstract	Nucleotide reverse transcriptase inhibitors, such as zidovudine (azidothymidine, AZT) and stavudine, represent a class of approved antiretroviral agents for highly active antiretroviral therapy, which prolongs the life expectancy of patients infected with human-immunodeficiency virus. Unfortunately, the use of these drugs is associated with known toxicities in the liver, skeletal muscle, heart and other organs, which may involve increased reactive oxygen species (ROS) generation, among other mechanisms. Resveratrol is a polyphenolic plant-derived antioxidant abundantly found in certain grapes, roots, berries, peanuts and red wine. This study, using primary human cardiomyocytes, evaluated the effects of AZT and pre-treatment with resveratrol on mitochondrial ROS generation and the cell death pathways. AZT induced concentration-dependent cell death, involving both caspase-3 and -7 and poly(ADP-ribose) polymerase activation, coupled with increased mitochondrial ROS generation in human cardiomyocytes. These effects of AZT on mitochondrial ROS generation and cell death may be attenuated by resveratrol pre-treatment. The results demonstrate that mitochondrial ROS generation plays a pivotal role in the cardiotoxicity of AZT in human cardiomyocytes, and resveratrol may provide a potential strategy to attenuate these pathological alterations, which are associated with widely used antiretroviral therapy.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2010.390
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	4
Language	English
Publisher	Spandidos Publications
Publisher Date	2011-01-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Anti-hiv Agents Adverse Effects Antioxidants Pharmacology Myocytes, Cardiac Drug Effects Reactive Oxygen Species Metabolism Stilbenes Zidovudine Acquired Immunodeficiency Syndrome Drug Therapy Apoptosis Caspase 3 Caspase 7 Cells, Cultured Mitochondria Cytology Research Support, N.i.h., Intramural Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes

Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression.

Resveratrol blocks high glucose-induced mitochondrial reactive oxygen species production in bovine aortic endothelial cells: role of phase 2 enzyme induction?

High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission.

Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species.

Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths.

Recombinant PTD-Cu/Zn SOD attenuates hypoxia-reoxygenation injury in cardiomyocytes.

Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?

Therapeutic Effect of Resveratrol on Oxidative Stress in Graves' Orbitopathy Orbital Fibroblasts.

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes.

Similar Documents

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes

Quercetin attenuates doxorubicin cardiotoxicity by modulating Bmi-1 expression.

Resveratrol blocks high glucose-induced mitochondrial reactive oxygen species production in bovine aortic endothelial cells: role of phase 2 enzyme induction?

High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission.

Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species.

Mitochondria-derived reactive oxygen species mediate caspase-dependent and -independent neuronal deaths.

Recombinant PTD-Cu/Zn SOD attenuates hypoxia-reoxygenation injury in cardiomyocytes.

Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?

Therapeutic Effect of Resveratrol on Oxidative Stress in Graves' Orbitopathy Orbital Fibroblasts.

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes.